Thomas Willmott
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View article: The human skin microbiome remains unchanged after 24 h of sunscreen application
The human skin microbiome remains unchanged after 24 h of sunscreen application Open
To ensure safe, long-term use, topical products should be investigated to understand how they interact with the resident skin microbiota to mitigate potential risk. Sunscreens are essential for protecting skin from UV damage, but their eff…
View article: Exploring intra-individual oral microbiome diversity and streptococcal colonization patterns
Exploring intra-individual oral microbiome diversity and streptococcal colonization patterns Open
Aims We have investigated bacterial colonization and site-specific distribution across hard and soft oral tissues focusing on both intra- and inter-individual patterns of Streptococcus clonality and overall microbial composition. Methods a…
View article: Distinct microbiome profiles on vaginally inserted polypropylene midurethral mesh slings compared to vaginal, urinary, and skin microbiomes
Distinct microbiome profiles on vaginally inserted polypropylene midurethral mesh slings compared to vaginal, urinary, and skin microbiomes Open
Midurethral slings are widely used in the treatment of stress urinary incontinence in women. However, little is known about the microbiomes that develop on these implants, their relationship to the urinary and vaginal microbiomes, or their…
View article: Co-infection with<i>Streptococcus</i>and<i>Rothia</i>spp. drives prophage dynamics in<i>Pseudomonas aeruginosa</i>in an artificial sputum model
Co-infection with<i>Streptococcus</i>and<i>Rothia</i>spp. drives prophage dynamics in<i>Pseudomonas aeruginosa</i>in an artificial sputum model Open
Objectives Chronic bacterial lung infections with Pseudomonas aeruginosa are common in people with cystic fibrosis (CF) but interactions with other commonly seen members of the CF lung community, such as Streptococcus and Rothia spp., are …
View article: Investigating oral microbiome dynamics in chronic kidney disease and post-transplantation in continuous culture
Investigating oral microbiome dynamics in chronic kidney disease and post-transplantation in continuous culture Open
The oral microbiome is influenced by environmental factors in chronic kidney disease and following kidney transplantation affecting microbial composition, which may have implications for health and recovery. A major driver of oral microbio…
View article: Investigating the association between nitrate dosing and nitrite generation by the human oral microbiota in continuous culture
Investigating the association between nitrate dosing and nitrite generation by the human oral microbiota in continuous culture Open
The generation of nitrite by the oral microbiota is believed to contribute to healthy cardiovascular function, with oral nitrate reduction to nitrite associated with systemic blood pressure regulation. There is the potential to manipulate …
View article: Sustainable application of biocides to promote hygiene and minimize antimicrobial resistance
Sustainable application of biocides to promote hygiene and minimize antimicrobial resistance Open
Biocidal (microbicidal) products play a critical role in controlling microorganisms in healthcare, industrial, community, and home environments. There is, however, concern that their use and misuse might contribute to the evolution of anti…
View article: Investigating the Association Between Nitrate Dosing and Nitrite Generation by the Human Oral Microbiota in Continuous Culture
Investigating the Association Between Nitrate Dosing and Nitrite Generation by the Human Oral Microbiota in Continuous Culture Open
The generation of nitrite by the oral microbiota is believed to contribute to healthy cardiovascular function, with oral nitrate reduction to nitrite associated with systemic blood pressure regulation. There is the potential to manipulate …
View article: Transplantation impacts on the oral microbiome of kidney recipients and donors
Transplantation impacts on the oral microbiome of kidney recipients and donors Open
Introduction Chronic kidney disease (CKD) may affect the human microbiome via increased concentrations of uremic toxins such as urea and creatinine. Methods We have profiled the oral microbiota in patients with CKD before and one week afte…
View article: Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation
Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation Open
BACKGROUND: The efficacy of dietary nitrate supplementation to lower blood pressure (BP) in pregnant women is highly variable. We aimed to investigate whether differences in oral microbiota profiles and oral nitrate-reducing capacity may e…
View article: Behaviour and sun exposure in holidaymakers alters skin microbiota composition and diversity
Behaviour and sun exposure in holidaymakers alters skin microbiota composition and diversity Open
Introduction: The skin microbiota plays a crucial role in maintaining epidermal homeostasis. Ultraviolet radiation (UVR) and other environmental challenges can impact the skin microbiota through direct and indirect mechanisms. This study a…
View article: Antibacterial effects in blood irradiated with a polychromatic device mediated through reactive oxygen species: possible involvement of haem
Antibacterial effects in blood irradiated with a polychromatic device mediated through reactive oxygen species: possible involvement of haem Open
The antibacterial effects of a polychromatic light device designed for intravenous application were assessed in vitro. Staphylococcus aureus, Klebsiella pneumoniae, or Escherichia coli were exposed to a 60-min sequential light cycle compri…
View article: Does the Oral Microbiome Play a Role in Hypertensive Pregnancies?
Does the Oral Microbiome Play a Role in Hypertensive Pregnancies? Open
Chronic hypertension during gestation is associated with an increased risk of adverse pregnancy outcomes including pre-eclampsia, fetal growth restriction and preterm birth. Research into new chemotherapeutic regimes for the treatment of h…