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View article: Long-term temporal stability of circulating proteins in older adults
Long-term temporal stability of circulating proteins in older adults Open
Circulating proteins reflect diverse biological processes and can offer critical insights into an individual‘s overall health and aging trajectory. The circulating proteome is shaped by a complex interplay of genetic, biological, and envir…
View article: Lifetime Exposure to Violence and Early Cardiometabolic Risk Factors in a Healthy Swedish Cohort
Lifetime Exposure to Violence and Early Cardiometabolic Risk Factors in a Healthy Swedish Cohort Open
Background Violence exposure has been associated with cardiovascular disease. Less is known about underlying mechanisms, including early cardiometabolic risk factors, and possible sex differences of such associations. Methods We used data …
View article: Long-term psychological effects of COVID-19-related quarantine: an observational study of three cohorts in Norway and Iceland
Long-term psychological effects of COVID-19-related quarantine: an observational study of three cohorts in Norway and Iceland Open
View article: Elements of burden among informal caregivers of community-dwelling older adults receiving home care nursing: a cross-sectional study on health status, well-being, and gender differences
Elements of burden among informal caregivers of community-dwelling older adults receiving home care nursing: a cross-sectional study on health status, well-being, and gender differences Open
Caregiver burden is a multidimensional construct with significant implications for caregiver well-being. Key predictors of reduced well-being include self-perceived burden, multifaceted strain, and a diminished sense of life satisfaction. …
View article: Trauma-Associated Sleep Disturbances among Women: A Nationwide Study
Trauma-Associated Sleep Disturbances among Women: A Nationwide Study Open
Trauma-associated sleep disorder (TASD) is a proposed REM-sleep parasomnia that arises after exposure to traumatic events. In a nationally representative sample of 29,653 Icelandic women aged 18–69, we found a TASD prevalence of 6.5%. Youn…
View article: Adverse childhood experiences and prevalence of type 2 diabetes in a nationwide study of women
Adverse childhood experiences and prevalence of type 2 diabetes in a nationwide study of women Open
We aimed to examine the association between adverse childhood experiences (ACEs) and type 2 diabetes in a nationwide cohort of Icelandic women, and to assess the mechanisms through which it is mediated. We used cross-sectional data from th…
View article: Mechanistic Insights into Tumorigenesis from Serum Proteins
Mechanistic Insights into Tumorigenesis from Serum Proteins Open
Improving early cancer detection would have a transformative effect on patient survival and associated societal costs. Ideally, this would involve tests that are minimally invasive, cancer-type specific and provide mechanistic insights. To…
View article: New Definition of Light Chain Monoclonal Gammopathy of Undetermined Significance
New Definition of Light Chain Monoclonal Gammopathy of Undetermined Significance Open
Importance Recent studies suggest standard reference intervals for serum free light chains (FLC) are inaccurate and that this problem can only be partially remedied by using separate reference intervals for individuals with impaired kidney…
View article: Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults
Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults Open
Identifying specific factors affecting psychological resilience could be instrumental in developing new therapeutic strategies for improving and maintaining mental and physical health. To achieve this, an adequate measure of psychological …
View article: Circulating causal protein networks linked to future risk of myocardial infarction
Circulating causal protein networks linked to future risk of myocardial infarction Open
Variations in blood protein levels have been associated with a broad spectrum of complex diseases, including atherosclerotic cardiovascular disease (ACVD). These associations highlight the intricate interplay between local (e.g., cardiovas…
View article: Perimenopausal symptoms in women with and without ADHD: A population-based cohort study
Perimenopausal symptoms in women with and without ADHD: A population-based cohort study Open
Background Knowledge of the impact of perimenopause on women with attention-deficit/hyperactivity disorder (ADHD) is lacking. We compared levels of perimenopausal symptoms and prevalence of severe perimenopausal symptoms among women with a…
View article: Adverse childhood experiences, mental distress, and autoimmune disease in adult women: findings from two large cohort studies
Adverse childhood experiences, mental distress, and autoimmune disease in adult women: findings from two large cohort studies Open
Background Adverse childhood experiences (ACEs) have been associated with increased risks of autoimmune diseases. However, data are scarce on the role of specific ACEs as well as the potential mediating role of adverse mental health sympto…
View article: Prevalence of Life Stressors and Posttraumatic Stress Disorder Among Women in Iceland
Prevalence of Life Stressors and Posttraumatic Stress Disorder Among Women in Iceland Open
Importance Comprehensive data on the prevalence of various life stressors and their role in posttraumatic stress disorder (PTSD) among women are lacking. Objective To determine the prevalence of a broad range of life stressors and their as…
View article: Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants
Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants Open
View article: Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data
Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data Open
Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Using data from seven cohort studies (N =…
View article: Sexual violence in the workplace and associated health outcomes: a nationwide, cross-sectional analysis of women in Iceland
Sexual violence in the workplace and associated health outcomes: a nationwide, cross-sectional analysis of women in Iceland Open
Reykjavík Energy Research Fund, The Icelandic Gender Equality Fund, European Research Council, and Icelandic Center for Research.
View article: Refracture and mortality risk in the elderly with osteoporotic fractures: the AGES-Reykjavik study
Refracture and mortality risk in the elderly with osteoporotic fractures: the AGES-Reykjavik study Open
View article: Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data
Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data Open
Background: Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Therefore, we aimed to invest…
View article: Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data
Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data Open
Background Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Therefore, we aimed to investi…
View article: Adverse Childhood Experiences and Adult Mental Health Outcomes
Adverse Childhood Experiences and Adult Mental Health Outcomes Open
Importance Exposure to adverse childhood experiences (ACEs) has consistently been associated with multiple negative mental health outcomes extending into adulthood. However, given that ACEs and psychiatric disorders cluster within families…
View article: Nocturnal gastro-oesophageal reflux and respiratory symptoms are increased in sleep apnoea: comparison with the general population
Nocturnal gastro-oesophageal reflux and respiratory symptoms are increased in sleep apnoea: comparison with the general population Open
Aim To assess respiratory symptoms and nocturnal gastro-oesophageal reflux (nGER) among untreated obstructive sleep apnoea (OSA) patients, compared with the general population. Also, if nGER associates differently with respiratory symptoms…
View article: Prior cancer and risk of monoclonal gammopathy of undetermined significance: a population-based study in Iceland and Sweden
Prior cancer and risk of monoclonal gammopathy of undetermined significance: a population-based study in Iceland and Sweden Open
There is some evidence that a prior cancer is a risk factor for the development of multiple myeloma (MM). If this is true, prior cancer should be associated with higher prevalence or increased progression rate of monoclonal gammopathy of u…
View article: Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer’s disease
Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer’s disease Open
The current demand for early intervention, prevention, and treatment of late onset Alzheimer’s disease (LOAD) warrants deeper understanding of the underlying molecular processes which could contribute to biomarker and drug target discovery…
View article: Serum proteomics reveals<i>APOE</i>dependent and independent protein signatures in Alzheimer’s disease
Serum proteomics reveals<i>APOE</i>dependent and independent protein signatures in Alzheimer’s disease Open
Summary The current demand for early intervention, prevention, and treatment of late onset Alzheimer’s disease (LOAD) warrants deeper understanding of the underlying molecular processes which could contribute to biomarker and drug target d…
View article: Vascular Age Assessed From an Uncalibrated, Noninvasive Pressure Waveform by Using a Deep Learning Approach: The AI-VascularAge Model
Vascular Age Assessed From an Uncalibrated, Noninvasive Pressure Waveform by Using a Deep Learning Approach: The AI-VascularAge Model Open
BACKGROUND: Aortic stiffness, assessed as carotid-femoral pulse wave velocity, provides a measure of vascular age and risk for adverse cardiovascular disease outcomes, but it is difficult to measure. The shape of arterial pressure waveform…
View article: COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark
COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark Open
View article: Lifetime exposure to violence and early cardiometabolic risk factors in a healthy Swedish cohort
Lifetime exposure to violence and early cardiometabolic risk factors in a healthy Swedish cohort Open
Introduction Violence exposure has been associated with cardiovascular disease. Less is known about underlying mechanisms, including early cardiometabolic risk factors, and possible sex differences of such associations. Methods We used dat…
View article: Childhood maltreatment and subsequent risk of hospitalization or death due to COVID-19: a cohort study in the UK Biobank
Childhood maltreatment and subsequent risk of hospitalization or death due to COVID-19: a cohort study in the UK Biobank Open
Childhood maltreatment has been associated with some infection-related outcomes, yet its potential role in severe COVID-19 outcomes has not been addressed. Therefore, leveraging longitudinal data from the population-based UK Biobank (N=151…
View article: Elevated symptoms of depression and anxiety among family members and friends of critically ill COVID-19 patients – an observational study of five cohorts across four countries
Elevated symptoms of depression and anxiety among family members and friends of critically ill COVID-19 patients – an observational study of five cohorts across four countries Open
View article: Proteomic associations with forced expiratory volume – a Mendelian randomisation study
Proteomic associations with forced expiratory volume – a Mendelian randomisation study Open
A decline in forced expiratory volume (FEV1) is a hallmark of obstructive respiratory diseases, an important cause of morbidity among the elderly. While some data exist on biomarkers that are related to FEV1, we sought to do a systematic a…