Thor Petersen
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View article: Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis
Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis Open
Background The kappa free light chain (κ-FLC) index is a well-established biomarker in multiple sclerosis (MS). While the prognostic value of the κ-FLC index has been demonstrated in early relapsing–remitting MS, its prognostic value in pr…
View article: Elevated Matrix Metalloproteinase Type 9 (MMP-9) Transcripts After Thymoglobulin Induction in Incident Kidney Transplant Recipients
Elevated Matrix Metalloproteinase Type 9 (MMP-9) Transcripts After Thymoglobulin Induction in Incident Kidney Transplant Recipients Open
Matrix metalloproteinase type 9 (MMP-9), which cleaves collagen type IV in basal membranes, has been associated with the progression of chronic kidney disease. The objective of the present study was to evaluate the characteristics of donor…
View article: Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals
Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals Open
Aging is associated with declines in muscle mass, strength, aerobic capacity, and metabolic health, accompanied by increased low-grade inflammation. The purpose of this study was to assess the effects of 12 weeks of resistance training (RT…
View article: The impact of educational attainment on diagnostic and treatment delays in multiple sclerosis: a nationwide cohort study in Denmark
The impact of educational attainment on diagnostic and treatment delays in multiple sclerosis: a nationwide cohort study in Denmark Open
Background: In multiple sclerosis (MS), the educational gradient in diagnostic and disease-modifying treatment (DMT) delays is sparsely examined, and the results are mixed. Objectives: Among patients with relapsing-remitting MS (RRMS), we …
View article: The Nordic Textile Collaboration: Final Report – Results and Recommendations
The Nordic Textile Collaboration: Final Report – Results and Recommendations Open
The Nordic Textile Collaboration (2022-2024) addressed the environmental challenges associated with textile consumption in the Nordics. The project implemented three initiatives:1. Active Textile Society: Engaging brands and citizens to su…
View article: T cells from newly diagnosed multiple sclerosis patients have enhanced responsiveness to <scp>CD46</scp> activation
T cells from newly diagnosed multiple sclerosis patients have enhanced responsiveness to <span>CD46</span> activation Open
Objective To evaluate the responsiveness of T cells from newly diagnosed multiple sclerosis (MS) patients to CD46 co‐stimulation, a membrane co‐factor protein potentially involved in MS pathogenesis. Methods T cells from MS patients and no…
View article: Telecoaching of Individuals With Multiple Sclerosis After Inpatient Multidisciplinary Rehabilitation: The Danish MS Hospitals Rehabilitation Study
Telecoaching of Individuals With Multiple Sclerosis After Inpatient Multidisciplinary Rehabilitation: The Danish MS Hospitals Rehabilitation Study Open
BACKGROUND: Inpatient rehabilitation improves health-related quality of life (HRQOL) for people with multiple sclerosis (MS). However, the obtained improvements decline once people return home. The challenge is to find ways to preserve the…
View article: Urine-derived stem cells serve as a robust platform for generating native or engineered extracellular vesicles
Urine-derived stem cells serve as a robust platform for generating native or engineered extracellular vesicles Open
View article: Shedding Light on the Black Box of Rehabilitation: Differential Short- and Long-Term Effects of Multidisciplinary Multiple Sclerosis Rehabilitation
Shedding Light on the Black Box of Rehabilitation: Differential Short- and Long-Term Effects of Multidisciplinary Multiple Sclerosis Rehabilitation Open
BACKGROUND: The study of the effectiveness of multidisciplinary rehabilitation (MDR) and how the symptoms and needs of individuals with multiple sclerosis (MS) interplay with the diversity of MDR interventions is still a conundrum, often r…
View article: Urine-derived stem cells; A robust platform for generating native or engineered autologous Extracellular Vesicles
Urine-derived stem cells; A robust platform for generating native or engineered autologous Extracellular Vesicles Open
Background Mesenchymal stem cell (MSC) therapy holds great potential as a treatment form, yet efficacy and safety concerns with cell therapy persist. The beneficial effects of MSCs are often attributed to their secretome, including extrace…
View article: Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis Open
HP1α/CBX5 is an epigenetic regulator with a suspected role in multiple sclerosis (MS). Here, using high-depth RNA sequencing on monocytes, we identified a subset of MS patients with reduced CBX5 expression, correlating with progressive sta…
View article: Neuroborreliosis interpreted as multiple sclerosis by MRI
Neuroborreliosis interpreted as multiple sclerosis by MRI Open
Lyme neuroborreliosis (LNB) is the most prevalent nervous system bacterial infection in Denmark. In a young man with LNB, brain MRI and cerebrospinal fluid (CSF) demonstrated findings compatible with multiple sclerosis. This case report un…
View article: Fatigue and Sleepiness in Multiple Sclerosis and Their Response to Short‐Term Treatment With Modafinil
Fatigue and Sleepiness in Multiple Sclerosis and Their Response to Short‐Term Treatment With Modafinil Open
Background: Patients with multiple sclerosis (pwMS) often experience significant fatigue. Simultaneously, previous studies show that pwMS frequently suffer from sleepiness and sleep problems. We aimed to contribute to the understanding of …
View article: Differentiation of MS lesions through analysis of microvascular distribution
Differentiation of MS lesions through analysis of microvascular distribution Open
Conventional MRI is crucial for diagnosing multiple sclerosis (MS) but lacks precision, leading to the clinico-radiological paradox and misdiagnosis risk, especially when confronted with unspecific lesions not related to MS. Advancements i…
View article: Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study
Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study Open
Background Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS). Objective To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressiv…
View article: Comparative effectiveness and cost-effectiveness of natalizumab and fingolimod in rapidly evolving severe relapsing-remitting multiple sclerosis in the United Kingdom
Comparative effectiveness and cost-effectiveness of natalizumab and fingolimod in rapidly evolving severe relapsing-remitting multiple sclerosis in the United Kingdom Open
This MSBase Registry analysis suggests that natalizumab improves clinical outcomes when compared with fingolimod, which translates to higher QALYs and lower costs in UK patients with RES-RRMS.
View article: Pharmacokinetics and pharmacodynamics of cannabis‐based medicine in a patient population included in a randomized, placebo‐controlled, clinical trial
Pharmacokinetics and pharmacodynamics of cannabis‐based medicine in a patient population included in a randomized, placebo‐controlled, clinical trial Open
Information on the pharmacokinetics (PK) and pharmacodynamics (PD) of orally administered cannabis‐based medicine (CBM) in capsule formulation in patient populations is sparse. In this exploratory study, we aimed to evaluate the PK and PD …
View article: Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis Open
HP1α/CBX5 is an epigenetic regulator with a suspected role in multiple sclerosis (MS). Here, using high-depth RNA sequencing on monocytes, we identified a subset of MS patients with reduced CBX5 expression, correlating with progressive sta…
View article: Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies
Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies Open
View article: Cannabis-Based Medicine for Neuropathic Pain and Spasticity—A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial
Cannabis-Based Medicine for Neuropathic Pain and Spasticity—A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial Open
Patients with multiple sclerosis (MS) and spinal cord injury (SCI) commonly sustain central neuropathic pain (NP) and spasticity. Despite a lack of consistent evidence, cannabis-based medicine (CBM) has been suggested as a supplement treat…
View article: The risk of secondary progressive multiple sclerosis is geographically determined but modifiable
The risk of secondary progressive multiple sclerosis is geographically determined but modifiable Open
Geographical variations in the incidence and prevalence of multiple sclerosis have been reported globally. Latitude as a surrogate for exposure to ultraviolet radiation but also other lifestyle and environmental factors are regarded as dri…
View article: Comparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis
Comparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis Open
Importance Autologous hematopoietic stem cell transplant (AHSCT) is available for treatment of highly active multiple sclerosis (MS). Objective To compare the effectiveness of AHSCT vs fingolimod, natalizumab, and ocrelizumab in relapsing-…
View article: Comparative effectiveness in multiple sclerosis: A methodological comparison
Comparative effectiveness in multiple sclerosis: A methodological comparison Open
Background: In the absence of evidence from randomised controlled trials, observational data can be used to emulate clinical trials and guide clinical decisions. Observational studies are, however, susceptible to confounding and bias. Amon…
View article: Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis
Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis Open
Background and purpose This study assessed the effect of patient characteristics on the response to disease‐modifying therapy (DMT) in multiple sclerosis (MS). Methods We extracted data from 61,810 patients from 135 centers across 35 count…
View article: Spinal manipulative therapy in older adults with chronic low back pain: an individual participant data meta-analysis
Spinal manipulative therapy in older adults with chronic low back pain: an individual participant data meta-analysis Open
Purpose Many systematic reviews have reported on the effectiveness of spinal manipulative therapy (SMT) for low back pain (LBP) in adults. Much less is known about the older population regarding the effects of SMT. Objective To assess the …
View article: Confirmed disability progression as a marker of permanent disability in multiple sclerosis
Confirmed disability progression as a marker of permanent disability in multiple sclerosis Open
Background and purpose The prevention of disability over the long term is the main treatment goal in multiple sclerosis (MS); however, randomized clinical trials evaluate only short‐term treatment effects on disability. This study aimed to…
View article: Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis
Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis Open
In temperate zones, MS severity is associated with latitude. This association is mainly, but not exclusively, driven by UVB exposure contributing to both MS susceptibility and severity.
View article: The Effect of Cannabis-Based Medicine on Neuropathic Pain and Spasticity in Patients with Multiple Sclerosis and Spinal Cord Injury: Study Protocol of a National Multicenter Double-Blinded, Placebo-Controlled Trial
The Effect of Cannabis-Based Medicine on Neuropathic Pain and Spasticity in Patients with Multiple Sclerosis and Spinal Cord Injury: Study Protocol of a National Multicenter Double-Blinded, Placebo-Controlled Trial Open
Disease or acquired damage to the central nervous system frequently causes disabling spasticity and central neuropathic pain (NP), both of which are frequent in multiple sclerosis (MS) and spinal cord injury (SCI). Patients with MS and SCI…
View article: Longitudinally extensive transverse myelitis and Hepatitis C—a case report and literature review
Longitudinally extensive transverse myelitis and Hepatitis C—a case report and literature review Open
Tractopathy lesions in the spinal cord associated with HCV infection, which normalized on MRI after antiviral treatment, are described. These specific MRI findings can be used in the diagnosis and treatment of secondary causes of transvers…
View article: The effect of spinal manipulative therapy on pain relief and function in patients with chronic low back pain: an individual participant data meta-analysis
The effect of spinal manipulative therapy on pain relief and function in patients with chronic low back pain: an individual participant data meta-analysis Open