Thorsten Stanley
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View article: Efficacy, Immunogenicity, and Safety of an Investigational Maternal Respiratory Syncytial Virus Prefusion F Protein–Based Vaccine
Efficacy, Immunogenicity, and Safety of an Investigational Maternal Respiratory Syncytial Virus Prefusion F Protein–Based Vaccine Open
Background In this phase 3 trial of an investigational maternal respiratory syncytial virus prefusion F protein–based vaccine (RSVPreF3-Mat), a higher rate of preterm birth was observed in the vaccine (6.8%) versus the placebo group (4.9%)…
View article: Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results
Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results Open
Respiratory syncytial virus (RSV) infection is the leading cause of infant hospitalizations and mortality. Lumicitabine, an oral nucleoside analog was studied for the treatment of RSV. The phase 1b and phase 2b studies reported here assess…
View article: Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus Vaccine (RSVPreF3) in Mothers and Their Infants: A Phase 2 Randomized Trial
Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus Vaccine (RSVPreF3) in Mothers and Their Infants: A Phase 2 Randomized Trial Open
Background In a phase 1/2 study, a maternal respiratory syncytial virus vaccine candidate (RSVPreF3) demonstrated an acceptable safety profile and efficiently increased RSV-specific humoral immune responses in non-pregnant women. Methods I…
View article: Heart rate variability as a marker of autonomic nervous system activity in young people with eosinophilic and non-eosinophilic asthma
Heart rate variability as a marker of autonomic nervous system activity in young people with eosinophilic and non-eosinophilic asthma Open
An imbalance in autonomic nervous system (ANS) activity may play a role in asthma, but it is unclear whether this is associated with specific pathophysiology. This study assessed ANS activity by measuring heart rate variability (HRV) in eo…
View article: Enhanced airway sensory nerve reactivity in non-eosinophilic asthma
Enhanced airway sensory nerve reactivity in non-eosinophilic asthma Open
Background Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics. Methods Thirt…
View article: Phenotypic Spectrum of Seizure Disorders in MBD5-Associated Neurodevelopmental Disorder
Phenotypic Spectrum of Seizure Disorders in MBD5-Associated Neurodevelopmental Disorder Open
MBD5 disruption may be associated with severe early childhood-onset developmental and epileptic encephalopathy. Because neuropsychiatric dysfunction is common and severe, it should be an important focus of clinical management.
View article: Enhanced sensory nerve reactivity in non-eosinophilic asthma
Enhanced sensory nerve reactivity in non-eosinophilic asthma Open
Background: Neural mechanisms may play an important role in non-eosinophilic asthma. This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic and non-eosinophilic asthma and non-asthmatics. Methods: T…
View article: Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial
Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial Open
We have previously shown that probiotic supplementation with Lactobacillus rhamnosus HN001 (HN001) led to a reduced incidence of gestational diabetes mellitus (GDM). Here we investigate whether HN001 supplementation resulted in alterations…
View article: The epileptology of GNB5 encephalopathy
The epileptology of GNB5 encephalopathy Open
Pathogenic variants in GNB5 cause an autosomal recessive neurodevelopmental disorder with neonatal sinus bradycardia. Seizures or epilepsy occurred in 10 of 22 previously reported cases, including 6 children from one family. We delineate t…
View article: Damp mouldy housing and early childhood hospital admissions for acute respiratory infection: a case control study
Damp mouldy housing and early childhood hospital admissions for acute respiratory infection: a case control study Open
Introduction A gap exists in the literature regarding dose–response associations of objectively assessed housing quality measures, particularly dampness and mould, with hospitalisation for acute respiratory infection (ARI) among children. …
View article: Indoor visible mold and mold odor are associated with new-onset childhood wheeze in a dose-dependent manner
Indoor visible mold and mold odor are associated with new-onset childhood wheeze in a dose-dependent manner Open
Evidence is accumulating that indoor dampness and mold are associated with the development of asthma. The underlying mechanisms remain unknown. New Zealand has high rates of both asthma and indoor mold and is ideally placed to investigate …
View article: Early pregnancy probiotic supplementation with <i>Lactobacillus rhamnosus</i> HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial
Early pregnancy probiotic supplementation with <i>Lactobacillus rhamnosus</i> HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial Open
The study aims to assess whether supplementation with the probiotic Lactobacillus rhamnosus HN001 (HN001) can reduce the prevalence of gestational diabetes mellitus (GDM). A double-blind, randomised, placebo-controlled parallel trial was c…
View article: Association of Vitamin D Deficiency with Severity of Acute Respiratory Infection: A Case-Control Study in New Zealand Children
Association of Vitamin D Deficiency with Severity of Acute Respiratory Infection: A Case-Control Study in New Zealand Children Open
Background: Acute respiratory infections (ARI) are a major source of childhood morbidity and excess winter hospitalisations. Vitamin D modulates innate immunity with recent associations demonstrated between vitamin D deficiency and seve…