Quynh‐Thu Le
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View article: Association of life’s crucial 9 and gallstone disease in United States adults compared to life’s essential 8: NHANES 2017-2018
Association of life’s crucial 9 and gallstone disease in United States adults compared to life’s essential 8: NHANES 2017-2018 Open
Objective: Cardiovascular health (CVH) represents a composite measure of key lifestyle behaviors and physiological factors. Life’s Essential 8 (LE8) quantifies eight domains of CVH, while Life’s Crucial 9 (LC9) extends this framework by in…
View article: Alphavirus replicon particle expressing IL-12 reprograms tumor-associated macrophages and neutrophils and induces anti-tumor immunity
Alphavirus replicon particle expressing IL-12 reprograms tumor-associated macrophages and neutrophils and induces anti-tumor immunity Open
Cancers evade anti-tumor immunity by the infiltration of immunosuppressive myeloid cells such as macrophages and neutrophils into the tumor microenvironment (TME). The limited efficacy of current immunotherapy is attributed to the presence…
View article: Discovery of potent inhibitors of NS4B protein of dengue virus type 2 from natural compounds: an in silico approach
Discovery of potent inhibitors of NS4B protein of dengue virus type 2 from natural compounds: an in silico approach Open
Dengue fever is an annual infectious epidemic disease caused by the Dengue virus, mainly found in tropical and subtropical regions. Of which, Dengue virus type 2 (DENV2) has been a major cause of severe cases globally. Currently, NS4B is o…
View article: Phase II Study of Low-Dose Paclitaxel and Cisplatin in Combination With Split-Course Concomitant Twice-Daily Reirradiation in Recurrent Squamous Cell Carcinoma of the Head and Neck: Long-term Follow-up of NRG Oncology RTOG 9911
Phase II Study of Low-Dose Paclitaxel and Cisplatin in Combination With Split-Course Concomitant Twice-Daily Reirradiation in Recurrent Squamous Cell Carcinoma of the Head and Neck: Long-term Follow-up of NRG Oncology RTOG 9911 Open
Despite a high incidence of grade 5 toxicity, OS rates for this trial evaluating concurrent split course twice a day reirradiation with cisplatin and paclitaxel exceeded results seen historically with chemotherapy alone.
View article: Automated radiotherapy treatment planning guided by GPT-4Vision
Automated radiotherapy treatment planning guided by GPT-4Vision Open
Objective . Radiotherapy treatment planning is a time-consuming and potentially subjective process that requires iterative adjustment of model parameters to balance multiple conflicting objectives. Recent advancements in frontier artificia…
View article: VISTA immune checkpoint blunts radiotherapy-induced antitumor immune response
VISTA immune checkpoint blunts radiotherapy-induced antitumor immune response Open
Radiotherapy (RT) is a key treatment for solid neoplasms like head and neck cancer (HNC), but it can also activate and recruit immunosuppressive myeloid cells, causing treatment failure. In this study, we examine the role of V-domain immun…
View article: The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5
The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5 Open
Glutamine reprogramming plays a crucial role in the growth and survival of clear cell renal cell carcinoma (ccRCC), although the mechanisms governing its regulation are still not fully understood. We demonstrate that the RNA demethylase fa…
View article: FTO inhibition enhances the therapeutic index of radiation therapy in head and neck cancer
FTO inhibition enhances the therapeutic index of radiation therapy in head and neck cancer Open
Despite aggressive chemoradiation treatment, the overall survival rate for patients with HPV- head and neck squamous cell carcinoma (HNSCC) remains poor, highlighting the urgent need for more effective drug-radiotherapy combinations to imp…
View article: Evaluation of Bioactivity Effects of <i>Paramignya trimera</i> in the Treatment of Lung Cancer through <i>In Silico</i> Approaches
Evaluation of Bioactivity Effects of <i>Paramignya trimera</i> in the Treatment of Lung Cancer through <i>In Silico</i> Approaches Open
The present study is an attempt to evaluate the bioactivity effects of the Paramignya trimera (P. trimera) extract using in silico approaches. Network pharmacology was initially applied to identify potential pathways and key targets relate…
View article: O-187 Individualized luteal phase support with intramuscular progesterone in patients with low serum progesterone on the day of frozen-thawed embryo transfer: a randomized clinical trial
O-187 Individualized luteal phase support with intramuscular progesterone in patients with low serum progesterone on the day of frozen-thawed embryo transfer: a randomized clinical trial Open
Study question Does the addition of intramuscular progesterone improve frozen embryo transfer (FET) outcomes in patients with low serum progesterone levels on the day of embryo transfer? Summary answer Supplementing with intramuscular prog…
View article: Sjögren’s Syndrome–Associated Fulminant Myocarditis Presenting as Cardiogenic Shock Requiring VA-ECMO: A Case Report
Sjögren’s Syndrome–Associated Fulminant Myocarditis Presenting as Cardiogenic Shock Requiring VA-ECMO: A Case Report Open
Fulminant autoimmune myocarditis is a rare but life-threatening condition that can present as the initial manifestation of an underlying autoimmune disease. Early recognition and prompt initiation of mechanical circulatory support and immu…
View article: International Consensus Guideline on Delineation of the Clinical Target Volumes at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version)
International Consensus Guideline on Delineation of the Clinical Target Volumes at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version) Open
Amidst the challenges of diverging practices, a comprehensive consensus guideline has been devised based on updated evidence and collective agreement among international experts. This serves as a practical reference for optimal target cove…
View article: MONTAGE: A Computation Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities
MONTAGE: A Computation Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities Open
Single-cell spatial-omics has advanced our understanding of how tumor microenvironment contributes to cancer progression. However, most single-cell spatial-omics studies focus on cell types and neighborhoods, offering limited information a…
View article: Supplementary Table S2 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Table S2 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Patient and tumor characteristics by inclusion in analysis.
View article: Supplementary Figure S1 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Figure S1 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Analysis of local failure, local-regional failure, disease-free survival and overall survival
View article: Supplementary Table S3 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Table S3 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Data on NFE2L2/KEAP1/CUL3 mutations
View article: Supplementary Table S6 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Table S6 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
First failure for disease-free survival by mutation status
View article: Data from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Data from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Purpose:NFE2L2/KEAP1/CUL3 mutations have been validated for radioresistance in cell-based assays and animal models. However, clinical validation of these biomarkers has been challenging because of multimodality treatment regimens. This stu…
View article: Supplementary Table S5 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Table S5 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Prognostic biomarker analysis for local-regional failure
View article: Supplementary Figure S2 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Figure S2 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Study schema of NRG/RTOG 9512
View article: Supplementary Table S8 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Table S8 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Salvage therapy after local/reginal/distant relapse tumor by mutation status
View article: Supplementary Table S4 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Table S4 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Prognostic biomarker analysis for local failure
View article: Supplementary Table S1 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Table S1 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Representativeness of Study Participants
View article: Supplementary Table S9 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Table S9 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Predictive biomarker analysis for local failure, local-regional failure, disease-free survival, and overall survival
View article: Supplementary Table S7 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer
Supplementary Table S7 from Association between Locoregional Failure and <i>NFE2L2/KEAP1/CUL3</i> Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer Open
Prognostic biomarker analysis for disease-free survival and overall survival