Thuvan Piehler
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View article: The link between impact-induced tensile strain and dendritic spine morphology in porcine brain tissue
The link between impact-induced tensile strain and dendritic spine morphology in porcine brain tissue Open
Brain tissue as a material presents unique properties with a multitude of cell types and densities, varying degrees of axonal fiber diameters and blood vessels. These neural components are contained within a very viscous environment that u…
View article: Impact-Induced Cortical Strain Concentrations at the Sulcal Base and Its Implications for Mild Traumatic Brain Injury
Impact-Induced Cortical Strain Concentrations at the Sulcal Base and Its Implications for Mild Traumatic Brain Injury Open
This study investigated impact-induced strain fields within brain tissue surrogates having different cortical gyrification. Two elastomeric surrogates, one representative of a lissencephalic brain and the other of a gyrencephalic brain, we…
View article: Distinct and dementia‐related synaptopathy in the hippocampus after military blast exposures
Distinct and dementia‐related synaptopathy in the hippocampus after military blast exposures Open
Explosive shockwaves, and other types of blast exposures, are linked to injuries commonly associated with military service and to an increased risk for the onset of dementia. Neurological complications following a blast injury, including d…
View article: Blast waves from detonated military explosive reduce GluR1 and synaptophysin levels in hippocampal slice cultures
Blast waves from detonated military explosive reduce GluR1 and synaptophysin levels in hippocampal slice cultures Open
Explosives create shockwaves that cause blast-induced neurotrauma, one of the most common types of traumatic brain injury (TBI) linked to military service. Blast-induced TBIs are often associated with reduced cognitive and behavioral funct…
View article: Investigating Pressure Wave Impact on a Surrogate Head Model Using Numerical Simulation Techniques
Investigating Pressure Wave Impact on a Surrogate Head Model Using Numerical Simulation Techniques Open
There is an urgent need to understand the mechanism leading to mild traumatic brain injury (mTBI) resulting from blast wave impact to the head. The recent conflicts in Iraq and Afghanistan have heightened the awareness of head impact injur…
View article: Effects on Neurons and Hippocampal Slices by Single and Multiple Primary Blast Pressure Waves From Detonating Spherical Cyclotrimethylenetrinitramine (RDX) Explosive Charges
Effects on Neurons and Hippocampal Slices by Single and Multiple Primary Blast Pressure Waves From Detonating Spherical Cyclotrimethylenetrinitramine (RDX) Explosive Charges Open
Threshold shock-impulse levels required to induce cellular injury and cumulative effects upon single and/or multiple exposures are not well characterized. Currently, there are few in vitro experimental models with blast pressure waves gene…