Tuan D. Pham
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View article: A Distinct Form of Subcutaneous Fat Fibrosis Predicts Insulin Resistance in People with HIV
A Distinct Form of Subcutaneous Fat Fibrosis Predicts Insulin Resistance in People with HIV Open
Background People with HIV (PWH) are at heightened risk for type 2 diabetes (T2D) and insulin resistance (IR), even with effective antiretroviral therapy (ART). Adipose tissue dysfunction, including subcutaneous adipose tissue (SAT) fibros…
View article: A Perspective on Neuroscience Data Standardization with Neurodata Without Borders
A Perspective on Neuroscience Data Standardization with Neurodata Without Borders Open
Neuroscience research has evolved to generate increasingly large and complex experimental data sets, and advanced data science tools are taking on central roles in neuroscience research. Neurodata Without Borders (NWB), a standard language…
View article: Intrinsic threshold plasticity: cholinergic activation and role in the neuronal recognition of incomplete input patterns
Intrinsic threshold plasticity: cholinergic activation and role in the neuronal recognition of incomplete input patterns Open
Activity‐dependent changes in membrane excitability are observed in neurons across brain areas and represent a cell‐autonomous form of plasticity (intrinsic plasticity; IP) that in itself does not involve alterations in synaptic strength (…
View article: Intrinsic threshold plasticity: cholinergic activation and role in the neuronal recognition of incomplete input patterns - Data, figures and codes
Intrinsic threshold plasticity: cholinergic activation and role in the neuronal recognition of incomplete input patterns - Data, figures and codes Open
This includes codes, data, figures and dependencies of the following repository: https://github.com/HAN-CELL-LAB/PhamHansel-intrinsic-exc-2022
View article: Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit
Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit Open
Cerebral dopamine neurotrophic factor (CDNF) is expressed in the brain and is neuroprotective. We have previously shown that CDNF is also expressed in the bowel and that its absence leads to degeneration and autophagy in the enteric nervou…
View article: Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice
Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice Open
Cerebral dopamine neurotrophic factor (CDNF) is neuroprotective for nigrostriatal dopamine neurons and restores dopaminergic function in animal models of Parkinson's disease (PD). To understand the role of CDNF in mammals, we generated CDN…
View article: Role of paroxysmal depolarization in focal seizure activity
Role of paroxysmal depolarization in focal seizure activity Open
We analyze the role of inhibition in sustaining focal epileptic seizure activity. We review ongoing seizure activity at the mesoscopic scale that can be observed with microelectrode arrays as well as at the macroscale of standard clinical …
View article: A novel mechanism for amplification of sensory responses by the amygdala-TRN projections
A novel mechanism for amplification of sensory responses by the amygdala-TRN projections Open
Many forms of behavior require selective amplification of neuronal representations of relevant environmental signals. Following emotional learning, sensory stimuli drive enhanced responses in the sensory cortex. However, the brain circuits…
View article: Electrical synapses regulate both subthreshold integration and population activity of principal cells in response to transient inputs within canonical feedforward circuits
Electrical synapses regulate both subthreshold integration and population activity of principal cells in response to transient inputs within canonical feedforward circuits Open
As information about the world traverses the brain, the signals exchanged between neurons are passed and modulated by synapses, or specialized contacts between neurons. While neurotransmitter-based synapses tend to exert either excitatory …
View article: Electrical synapses and transient signals in feedforward canonical circuits
Electrical synapses and transient signals in feedforward canonical circuits Open
As information about the world traverses the brain, the signals exchanged between neurons are passed and modulated by synapses, or specialized contacts between neurons. While neurotransmitter-based synapses tend to be either relay excitato…
View article: The Role of Functional Neuroanatomy of the Lumbar Spinal Cord in Effect of Epidural Stimulation
The Role of Functional Neuroanatomy of the Lumbar Spinal Cord in Effect of Epidural Stimulation Open
In this study, the neuroanatomy of the swine lumbar spinal cord, particularly the spatial orientation of dorsal roots was correlated to the anatomical landmarks of the lumbar spine and to the magnitude of motor evoked potentials during epi…
View article: Electrical synapses between inhibitory neurons shape the responses of principal neurons to transient inputs in the thalamus
Electrical synapses between inhibitory neurons shape the responses of principal neurons to transient inputs in the thalamus Open
As multimodal sensory information proceeds to the cortex, it is intercepted and processed by the nuclei of the thalamus. The main source of inhibition within thalamus is the reticular nucleus (TRN), which collects signals both from thalamo…
View article: Fuzzy recurrence plots
Fuzzy recurrence plots Open
Recurrence plots display binary texture of time series from dynamical systems with single dots and line structures. Using fuzzy recurrence plots, recurrences of the phase-space states can be visualized as grayscale texture, which is more i…