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View article: Treatable Traits in Patients with Obstructive Lung Diseases in a Well-Established Asthma/COPD Service for Primary Care
Treatable Traits in Patients with Obstructive Lung Diseases in a Well-Established Asthma/COPD Service for Primary Care Open
The TTs assessed in this study are common in primary care patients, with nearly half of the patients showing a combination of at least two TTs. These TTs coexist in many different combinations. A personalized approach targeting these trait…
View article: Patient perspectives on the use of oral corticosteroids in asthma
Patient perspectives on the use of oral corticosteroids in asthma Open
HCPs should consider the impact that OCS have on their patients' wellbeing, including short courses. It is essential for HCPs to discuss the short and long-term risks of OCS with patients prior to initiation of treatment and consider alter…
View article: Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci
Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci Open
Asthma is a genetically complex inflammatory airway disease associated with more than 200 SNPs. However, the functional effects of many asthma-associated SNPs in lung and airway epithelial samples are unknown. Here, we aimed to conduct exp…
View article: Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS
Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS Open
Introduction Neutrophilic asthma has been suggested to be a clinically distinct phenotype characterised by more severe airflow obstruction and higher exacerbation risk. However, this has only been assessed in few and smaller studies, using…
View article: Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study
Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study Open
Introduction Asthma is an inflammatory airways disease encompassing multiple phenotypes and endotypes. Several studies suggested gene expression in nasal epithelium to serve as a proxy for bronchial epithelium, being a non-invasive approac…
View article: Sex differences in asthma control, lung function and exacerbations: the ATLANTIS study
Sex differences in asthma control, lung function and exacerbations: the ATLANTIS study Open
Background Asthma is a heterogeneous disease with a prevalence and severity that differs between male and female patients. Question What are differences between male and female patients with asthma with regard to asthma control, lung funct…
View article: The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project
The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project Open
The prevalence of severe asthma in Africa is high and is associated with high morbidity and poor quality of life.
View article: An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma Open
Background Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that target type 2-low inflammation. Previous studies have linked IL-6 signaling to severe asthm…
View article: Development of a tool to detect small airways dysfunction in asthma clinical practice
Development of a tool to detect small airways dysfunction in asthma clinical practice Open
Background Small airways dysfunction (SAD) in asthma is difficult to measure and a gold standard is lacking. The aim of this study was to develop a simple tool including items of the Small Airways Dysfunction Tool (SADT) questionnaire, bas…
View article: Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study
Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study Open
View article: Improved health status of severe COPD patients after being included in an integrated primary care service: A prospective cohort study
Improved health status of severe COPD patients after being included in an integrated primary care service: A prospective cohort study Open
An integrated service for COPD based in primary care may improve the health status of patients with a large burden of disease while not increasing health care costs.
View article: The role of small airway dysfunction in asthma control and exacerbations: a longitudinal, observational analysis using data from the ATLANTIS study
The role of small airway dysfunction in asthma control and exacerbations: a longitudinal, observational analysis using data from the ATLANTIS study Open
Chiesi Farmaceutici.
View article: Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic
Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic Open
The COVID-19 pandemic has brought a renewed focus on appropriate management of chronic respiratory conditions with a heightened awareness of respiratory symptoms and the requirement for differential diagnosis between an asthma attack and C…
View article: Brazilian version of the Clinical COPD Questionnaire, administered by interview: reliability and validity measurement properties
Brazilian version of the Clinical COPD Questionnaire, administered by interview: reliability and validity measurement properties Open
The Brazilian version of the CCQ showed an indeterminate measurement error, as well as satisfactory interrater/test-retest reliability and construct validity.
View article: Klinische bruikbaarheid en kwaliteit van spirometrie
Klinische bruikbaarheid en kwaliteit van spirometrie Open
View article: Work absence in patients with asthma and/or COPD: a population-based study
Work absence in patients with asthma and/or COPD: a population-based study Open
View article: COPD-Lower Respiratory Tract Infection Visual Analogue Score (c-LRTI-VAS) validation in stable and exacerbated patients with COPD
COPD-Lower Respiratory Tract Infection Visual Analogue Score (c-LRTI-VAS) validation in stable and exacerbated patients with COPD Open
Background We developed the chronic obstructive pulmonary disease (COPD)-Lower Respiratory Tract Infection-Visual Analogue Score (c-LRTI-VAS) in order to easily quantify symptoms during exacerbations in patients with COPD. This study aimed…
View article: Small Airway Dysfunction Predicts Asthma Control and Exacerbations : Longitudinal Data from the Assessment of Small Airways Involvement in Asthma (ATLANTIS) Study
Small Airway Dysfunction Predicts Asthma Control and Exacerbations : Longitudinal Data from the Assessment of Small Airways Involvement in Asthma (ATLANTIS) Study Open
View article: Patterns of Physical Activity Progression in Patients With COPD
Patterns of Physical Activity Progression in Patients With COPD Open
View article: <p>The Burden of Self-Reported Rhinitis and Associated Risk for Exacerbations with Moderate-Severe Asthma in Primary Care Patients</p>
The Burden of Self-Reported Rhinitis and Associated Risk for Exacerbations with Moderate-Severe Asthma in Primary Care Patients Open
This study identified a major gap in the diagnosis and management of rhinitis in a cohort of people with asthma treated at GINA Step 3 and above who are managed in general practice. It highlights the need for practitioners to identify, eva…
View article: Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy
Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy Open
Both the prevalence and the burden of allergic diseases are considerable with prevalence varying between 1% and 20%. We identified a plethora of studies on asthma, but studies were generally difficult to compare due to the heterogeneity in…
View article: Improving primary care management of asthma: do we know what really works?
Improving primary care management of asthma: do we know what really works? Open
Asthma imposes a substantial burden on individuals and societies. Patients with asthma need high-quality primary care management; however, evidence suggests the quality of this care can be highly variable. Here we identify and report facto…
View article: Commentary: “Healthcare Professionals’ Preferred Efficacy Endpoints and Minimal Clinically Important Differences in the Assessment of New Medicines for Chronic Obstructive Pulmonary Disease” by Dankers M et al. in Frontiers in Pharmacology 2020; 10: 1519
Commentary: “Healthcare Professionals’ Preferred Efficacy Endpoints and Minimal Clinically Important Differences in the Assessment of New Medicines for Chronic Obstructive Pulmonary Disease” by Dankers M et al. in Frontiers in Pharmacology 2020; 10: 1519 Open
GENERAL COMMENTARY article Front. Pharmacol., 02 June 2020 | https://doi.org/10.3389/fphar.2020.00827
View article: Skin prick reactivity among asthmatics in East Africa
Skin prick reactivity among asthmatics in East Africa Open
View article: Quality of spirometry and related diagnosis in primary care with a focus on clinical use
Quality of spirometry and related diagnosis in primary care with a focus on clinical use Open
American and European societies’ (ATS/ERS) criteria for spirometry are often not met in primary care. Yet, it is unknown if quality is sufficient for daily clinical use. We evaluated quality of spirometry in primary care based on clinical …
View article: Phenotypic characteristics and asthma severity in an East African cohort of adults and adolescents with asthma: findings from the African severe asthma project
Phenotypic characteristics and asthma severity in an East African cohort of adults and adolescents with asthma: findings from the African severe asthma project Open
Rationale The relationship between clinical and biomarker characteristics of asthma and its severity in Africa is not well known. Methods Using the Expert Panel Report 3, we assessed for asthma severity and its relationship with key phenot…
View article: A multinational observational study identifying primary care patients at risk of overestimation of asthma control
A multinational observational study identifying primary care patients at risk of overestimation of asthma control Open
Factors related to the discrepancy between patient-perceived and actual disease control remain unclear. Identifying patients at risk of overestimation of asthma control remains elusive. This study aimed to (i) investigate the relationship …
View article: <p>Progression Of Physical Inactivity In COPD Patients: The Effect Of Time And Climate Conditions – A Multicenter Prospective Cohort Study [Corrigendum]</p>
Progression Of Physical Inactivity In COPD Patients: The Effect Of Time And Climate Conditions – A Multicenter Prospective Cohort Study [Corrigendum] Open
[This corrects the article DOI: 10.2147/COPD.S208826.].
View article: <p>Progression of physical inactivity in COPD patients: the effect of time and climate conditions – a multicenter prospective cohort study</p>
Progression of physical inactivity in COPD patients: the effect of time and climate conditions – a multicenter prospective cohort study Open
COPD patients demonstrate a significant decrease in PA over 1 year follow-up, which is further affected by hours of rainfall, but not by other climate considerations.
View article: Baseline health status and setting impacted minimal clinically important differences in COPD: an exploratory study
Baseline health status and setting impacted minimal clinically important differences in COPD: an exploratory study Open