Tiago Carvalheiro
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View article: Profiling the immune tumor microenvironment of pediatric brain tumors with cavitron ultrasonic surgical aspirator (CUSA)-derived tissue fragments
Profiling the immune tumor microenvironment of pediatric brain tumors with cavitron ultrasonic surgical aspirator (CUSA)-derived tissue fragments Open
Background Current treatment options for pediatric high-grade brain tumors are limited, with poor 5-year overall survival rates. While immunotherapy is promising for these patients, the composition of their tumor immune microenvironment (T…
View article: DIPG-36. DRD2 ANTAGONISM RESCUES IMMUNE-TUMOR SURVEILLANCE, WARMING THE TUMOR IMMUNE MICROENVIRONMENT OF DIFFUSE MIDLINE GLIOMA MODELS
DIPG-36. DRD2 ANTAGONISM RESCUES IMMUNE-TUMOR SURVEILLANCE, WARMING THE TUMOR IMMUNE MICROENVIRONMENT OF DIFFUSE MIDLINE GLIOMA MODELS Open
BACKGROUND Less than 10% of patients with diffuse midline glioma (DMG) survive 2-years post-diagnosis, with no approved treatments other than palliative radiotherapy. Immune-checkpoint inhibition has failed in the clinic, likely due to a l…
View article: Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis
Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis Open
Tissue repair is disturbed in fibrotic diseases like systemic sclerosis (SSc), where the deposition of large amounts of extracellular matrix components such as collagen interferes with organ function. LAIR-1 is an inhibitory collagen recep…
View article: Role of monocytes and dendritic cells in cardiac reverse remodelling after cardiac resynchronization therapy
Role of monocytes and dendritic cells in cardiac reverse remodelling after cardiac resynchronization therapy Open
View article: IMMU-53. MONITOR THE IMMUNE MICROENVIRONMENT AND SYSTEMIC IMMUNE EFFECTS IN PEDIATRIC BRAIN TUMORS – THE MIMIC PROGRAM
IMMU-53. MONITOR THE IMMUNE MICROENVIRONMENT AND SYSTEMIC IMMUNE EFFECTS IN PEDIATRIC BRAIN TUMORS – THE MIMIC PROGRAM Open
INTRODUCTION Dismal outcomes of pediatric high-grade CNS tumors demand new therapeutic strategies. A better understanding of the immune system may contribute to designing better immunotherapies for these children. The MIMIC program (Dutch …
View article: IMMU-50. DIFFERENCES IN GUT MICROBIAL COMPOSITION BETWEEN PEDIATRIC BRAIN TUMOR PATIENTS AND HEALTHY CONTROLS – THE MIMIC PROGRAM
IMMU-50. DIFFERENCES IN GUT MICROBIAL COMPOSITION BETWEEN PEDIATRIC BRAIN TUMOR PATIENTS AND HEALTHY CONTROLS – THE MIMIC PROGRAM Open
INTRODUCTION The gut microbiome has been hypothesized to influence tumor initiation, immune evasion and treatment response in CNS tumor patients via the gut-brain axis, but data remains limited. To begin to address this question, we compar…
View article: IMMU-46. MONITORING T-CELL DYNAMICS AND CHECKPOINT EXPRESSION IN THE IMMUNE MICROENVIRONMENT OF PEDIATRIC HIGH GRADE BRAIN TUMORS: THE MIMIC PROGRAM
IMMU-46. MONITORING T-CELL DYNAMICS AND CHECKPOINT EXPRESSION IN THE IMMUNE MICROENVIRONMENT OF PEDIATRIC HIGH GRADE BRAIN TUMORS: THE MIMIC PROGRAM Open
BACKGROUND Pediatric high grade brain tumors (pHGBT) pose a significant challenge due to limited treatment options and poor prognosis. Understanding the immune landscape, in particular T cell profiles and functionality, is of high interest…
View article: IMMU-58. CHARACTERIZATION OF MYELOID CELL POPULATIONS IN PEDIATRIC HIGH-GRADE BRAIN TUMORS: THE MIMIC PROGRAM
IMMU-58. CHARACTERIZATION OF MYELOID CELL POPULATIONS IN PEDIATRIC HIGH-GRADE BRAIN TUMORS: THE MIMIC PROGRAM Open
BACKGROUND Pediatric high-grade brain tumors (pHGBT) pose treatment challenges with limited options. Myeloid cells, particularly tumor-associated macrophages (TAMs) in the tumor-microenvironment (TME), exhibit potent immunosuppressive feat…
View article: Reduced numbers of regulatory T cells in chronic heart failure seems not to be restored by cardiac resynchronization therapy
Reduced numbers of regulatory T cells in chronic heart failure seems not to be restored by cardiac resynchronization therapy Open
Background T cells have been implicated in the development and progression of inflammatory processes in chronic heart failure (CHF). Cardiac resynchronization therapy (CRT) has beneficial effects on symptoms and cardiac remodeling in CHF. …
View article: Chronic heart failure hampers regulatory T cell homeostasis which is not restored by cardiac resynchronization therapy
Chronic heart failure hampers regulatory T cell homeostasis which is not restored by cardiac resynchronization therapy Open
Background: T cells have been implicated in the development and progression of inflammatory process in chronic heart failure (CHF). Cardiac resynchronization therapy (CRT) has beneficial effects on symptoms and cardiac remodeling in CHF. H…
View article: Nuclear Receptor Subfamily <scp>4A</scp> Signaling as a Key Disease Pathway of <scp>CD1c</scp> + Dendritic Cell Dysregulation in Systemic Sclerosis
Nuclear Receptor Subfamily <span>4A</span> Signaling as a Key Disease Pathway of <span>CD1c</span> + Dendritic Cell Dysregulation in Systemic Sclerosis Open
Objective This study was undertaken to identify key disease pathways driving conventional dendritic cell (cDC) alterations in systemic sclerosis (SSc). Methods Transcriptomic profiling was performed on peripheral blood CD1c+ cDCs (cDC2s) i…
View article: New insights into the regulation of inflammation and fibrosis in systemic sclerosis
New insights into the regulation of inflammation and fibrosis in systemic sclerosis Open
Systemic sclerosis (SSc) is an autoimmune rheumatic disease characterized by vasculopathy, inflammation and fibrosis of the skin and internal organs. The aetiology of SSc is largely unknown, and its pathogenesis is complex and remains poor…
View article: CXCL4 drives fibrosis by promoting several key cellular and molecular processes
CXCL4 drives fibrosis by promoting several key cellular and molecular processes Open
View article: Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis
Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis Open
Tissue repair is disturbed in fibrotic diseases like systemic sclerosis (SSc), where the deposition of large amounts of extracellular matrix components such as collagen interferes with organ function. LAIR-1 is an inhibitory collagen recep…
View article: Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis
Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis Open
Objectives To identify key disease pathways driving conventional dendritic cell (cDC) alterations in Systemic Sclerosis (SSc). Methods Transcriptomic profiling was performed on peripheral blood CD1c+ cDCs (cDC2s) isolated from 12 healthy d…
View article: Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α
Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α Open
Objective SSc is a complex disease characterized by vascular abnormalities and inflammation culminating in hypoxia and excessive fibrosis. Previously, we identified chemokine (C-X-C motif) ligand 4 (CXCL4) as a novel predictive biomarker i…
View article: Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis
Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis Open
Compelling evidence shows the involvement of plasmacytoid dendritic cells (pDCs) in systemic sclerosis (SSc) pathogenesis. This study investigated whether microRNAs (miRNAs) are involved in the dysregulation of pDCs in SSc patients already…
View article: Angiopoietin-2 Promotes Inflammatory Activation in Monocytes of Systemic Sclerosis Patients
Angiopoietin-2 Promotes Inflammatory Activation in Monocytes of Systemic Sclerosis Patients Open
Angiopoietin-2 (Ang-2), a ligand of the tyrosine kinase receptor Tie2, is essential for vascular development and blood vessel stability and is also involved in monocyte activation. Here, we examined the role of Ang-2 on monocyte activation…
View article: Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in systemic sclerosis
Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in systemic sclerosis Open
View article: Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in Systemic Sclerosis
Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in Systemic Sclerosis Open
The T-cell receptor (TCR) is a highly polymorphic surface receptor that allows T-cells to recognize antigenic peptides presented on the major histocompatibility complex (MHC). Changes in the TCR repertoire have been observed in several aut…
View article: Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner
Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner Open
Semaphorin (Sema)4A is a transmembrane glycoprotein that is elevated in several autoimmune diseases such as systemic sclerosis, rheumatoid arthritis and multiple sclerosis. Sema4A has a key role in the regulation of Thelper Th1 and Th2 dif…
View article: Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation
Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation Open
Inhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor w…
View article: CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis
CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis Open
Our findings demonstrate that CXCL4 can drive fibroblast activation indirectly via PDGF-BB production by myeloid cells. Hence, targeting PDGF-BB or CXCL4-induced PDGF-BB release could be clinically beneficial for patients with SSc.
View article: Novel insights into dendritic cells in the pathogenesis of systemic sclerosis
Novel insights into dendritic cells in the pathogenesis of systemic sclerosis Open
Summary Systemic sclerosis (SSc) is a severe autoimmune fibrotic disease characterized by fibrosis, vasculopathy, and immune dysregulation. Dendritic cells (DCs) are the most potent antigen-presenting cells, specialized in pathogen sensing…
View article: Extracellular SPARC cooperates with TGF-β signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts
Extracellular SPARC cooperates with TGF-β signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts Open
Objectives SSc is an autoimmune disease characterized by inflammation, vascular injury and excessive fibrosis in multiple organs. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that regulates processes…
View article: Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients
Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients Open
Objective To examine the role of Tie2 signalling in macrophage activation within the context of the inflammatory synovial microenvironment present in patients with RA and PsA. Methods Clinical responses and macrophage function were examine…
View article: Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis
Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis Open
Objective To analyze the potential role of semaphorin 4A (Sema4A) in inflammatory and fibrotic processes involved in the pathology of systemic sclerosis ( SS c). Methods Sema4A levels in the plasma of healthy controls (n = 11) and SS c pat…
View article: Impact of cardiac resynchronization therapy on circulating IL-17 producing cells in patients with advanced heart failure
Impact of cardiac resynchronization therapy on circulating IL-17 producing cells in patients with advanced heart failure Open
View article: AB0193 Semaphorin4a induces th17 cytokine production in systemic sclerosis
AB0193 Semaphorin4a induces th17 cytokine production in systemic sclerosis Open
View article: OP0327 Cxcl4 drives fibrosis by promoting several key cellular and molecular processes
OP0327 Cxcl4 drives fibrosis by promoting several key cellular and molecular processes Open