Matheus de Freitas Silva
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View article: Resveratrol–Curcumin Hybrid Selectively Induces Chromosomal Abnormalities and Apoptosis in Colon Adenocarcinoma Cells
Resveratrol–Curcumin Hybrid Selectively Induces Chromosomal Abnormalities and Apoptosis in Colon Adenocarcinoma Cells Open
Colorectal cancer (CRC) therapy frequently relies on chemotherapeutic agents with high cytotoxicity, low selectivity, and suboptimal efficacy. Thus, the search for alternative therapeutic strategies for CRC continues. In the present work, …
View article: Novel Multifunctional Cannabidiol-Based Analogues with In Silico, In Vitro, and In Vivo Anti-SARS-CoV-2 Effect
Novel Multifunctional Cannabidiol-Based Analogues with In Silico, In Vitro, and In Vivo Anti-SARS-CoV-2 Effect Open
Background/Objectives: COVID-19 was responsible for millions of deaths worldwide. This study aimed to identify substances with in vitro and in vivo effects against the SARS-CoV-2 virus. Methods: Compounds PQM-243 and PQM-249, two terpene-N…
View article: PRODUÇÃO ARTESANAL DE ETANOL COM SACCHAROMYCES CEREVISIAE EM UMA ABORDAGEM INVESTIGATIVA PARA O ENSINO FUNDAMENTAL
PRODUÇÃO ARTESANAL DE ETANOL COM SACCHAROMYCES CEREVISIAE EM UMA ABORDAGEM INVESTIGATIVA PARA O ENSINO FUNDAMENTAL Open
A practical study of artisanal ethanol production was carried out with different brands of yeasts containing Saccharomyces cerevisiae, which are used for domestic and industrial use, in an investigative approach for elementary education, o…
View article: Curcumin-like Compound Inhibits Proliferation of Adenocarcinoma Cells by Inducing Cell Cycle Arrest and Senescence
Curcumin-like Compound Inhibits Proliferation of Adenocarcinoma Cells by Inducing Cell Cycle Arrest and Senescence Open
Background: Lung cancer is the leading cause of cancer-related death in the male sex worldwide. Non-small cell lung cancer (NSCLC) is the most prevalent type, accounting for 80–85% of cases, and lung adenocarcinoma is the most common and l…
View article: Use of supervised and unsupervised approaches to make zonal application maps for variable-rate application of crop growth regulators in commercial cotton fields
Use of supervised and unsupervised approaches to make zonal application maps for variable-rate application of crop growth regulators in commercial cotton fields Open
Background Zonal application maps are designed to represent field variability using key variables that can be translated into tailored management practices. For cotton, zonal maps for crop growth regulator (CGR) applications under variable…
View article: Prevalence of SARS-CoV-2 infections and socio-occupational profile of delivery riders during the COVID-19 pandemic
Prevalence of SARS-CoV-2 infections and socio-occupational profile of delivery riders during the COVID-19 pandemic Open
Introduction: We assessed the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated socio-occupational factors among delivery riders from a Brazilian city at two time points during the pandemic…
View article: Pharmacological Evaluation of the Traditional Brazilian Medicinal Plant Monteverdia ilicifolia in Gastroesophageal Reflux Disease: Preliminary Results of a Randomized Double-Blind Controlled Clinical Trial
Pharmacological Evaluation of the Traditional Brazilian Medicinal Plant Monteverdia ilicifolia in Gastroesophageal Reflux Disease: Preliminary Results of a Randomized Double-Blind Controlled Clinical Trial Open
Background/Objectives: The present work aimed to compare the effects of the standardized dry extract from the leaves of Monteverdia ilicifolia, popularly known as “espinheira-santa”, with omeprazole in the management of dyspepsia related t…
View article: Uma Investigação sobre Técnicas de Data Augmentation Aplicadas a Tradução Automática Português-LIBRAS
Uma Investigação sobre Técnicas de Data Augmentation Aplicadas a Tradução Automática Português-LIBRAS Open
The automatic translation from Portuguese to LIBRAS is extremely important for accessibility and inclusion of deaf individuals in society, but the scarcity of data and the high cost of building an authentic corpora pose significant challen…
View article: Conscientização ambiental na escola – oficina para minimizar impactos de forma sustentável
Conscientização ambiental na escola – oficina para minimizar impactos de forma sustentável Open
Environmental awareness and the importance of education as a tool to minimize the negative impacts of human activity on the environment. Since the dawn of time, man has interacted with nature to meet his basic needs, but misguided actions …
View article: A synthetic resveratrol–curcumin hybrid derivative exhibits chemopreventive effects on colon pre-neoplastic lesions by targeting Wnt/β-catenin signaling, anti-inflammatory and antioxidant pathways
A synthetic resveratrol–curcumin hybrid derivative exhibits chemopreventive effects on colon pre-neoplastic lesions by targeting Wnt/β-catenin signaling, anti-inflammatory and antioxidant pathways Open
Based on the effectiveness of resveratrol and curcumin in carcinogenesis, (E)-3-(4-hydroxy-3-methoxyphenyl)-Nʹ-((E)-4-methoxybenzylidene) acrylohydrazide (PQM-162), curcumin–resveratrol hybrid derivative, was designed by molecular hybridiz…
View article: Multi-functional Ligands and Molecular Hybridization: Conceptual Aspects and Application in the Innovative Design of Drug Candidate Prototypes for Neurodegenerative Diseases
Multi-functional Ligands and Molecular Hybridization: Conceptual Aspects and Application in the Innovative Design of Drug Candidate Prototypes for Neurodegenerative Diseases Open
The rapid increase in the incidence of dementia has enormous socioeconomic impacts and costs for governmental health systems all over the world. Despite this, finding an effective treatment for the different types of neurodegenerative dise…
View article: Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation
Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation Open
A new series of eight multifunctional thalidomide–donepezil hybrids were synthesized based on the multi-target-directed ligand strategy and evaluated as potential neuroprotective, cholinesterase inhibitors and anti-neuroinflammatory agents…
View article: Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes inDrug Design for Neuroprotective Agents
Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes inDrug Design for Neuroprotective Agents Open
: Nowadays, neurodegenerative diseases (NDs), such as Parkinson’s disease (PD), Alz-heimer’s disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), repre-sent a great challenge in different scientific fields, suc…
View article: Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder that involves different pathogenic mechanisms. In this regard, the goal of this study was the design and synthesis of new compounds with multifunctional pharmacologica…
View article: Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases
Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases Open
Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies related to neuronal impairment and functional loss from different brain regions. Currently, no effective treatments are available for any NDs, and thi…
View article: The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones
The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones Open
Chalcones have shown a broad spectrum of biological activities with clinical potential against various diseases. The biological activities are mainly attributed to the presence in the chalcones of the α,β-unsaturated carbonyl system, perce…
View article: Portuguese recommendations for the use of biological therapies in patients with psoriatic arthritis - 2015 update
Portuguese recommendations for the use of biological therapies in patients with psoriatic arthritis - 2015 update Open
Objective:To update recommendations for the treatment of psoriatic arthritis with biological therapies, endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheuma…