Tiago O. Almeida
YOU?
Author Swipe
View article: Profilin 1 controls a microglial cytoskeleton checkpoint to prevent senescence and premature synaptic decline
Profilin 1 controls a microglial cytoskeleton checkpoint to prevent senescence and premature synaptic decline Open
Profilin 1 (Pfn1) expression decreases significantly in aged human microglia, suggesting that loss of cytoskeletal integrity may trigger microglial senescence and increased synaptic vulnerability. To test this hypothesis, we used an induci…
View article: Profilin 1 Controls a Microglial Cytoskeleton Checkpoint to Prevent Senescence and Premature Synaptic Decline
Profilin 1 Controls a Microglial Cytoskeleton Checkpoint to Prevent Senescence and Premature Synaptic Decline Open
Profilin 1 (Pfn1) expression decreases significantly in aged human microglia, suggesting that loss of cytoskeletal integrity may trigger microglial senescence and increased synaptic vulnerability. To test this hypothesis, we used an induci…
View article: Energy Efficiency in Public Buildings – Case Study of Automation of the Air Conditioning System
Energy Efficiency in Public Buildings – Case Study of Automation of the Air Conditioning System Open
Objective: This study aims to demonstrate energy efficiency measures that enable effective control over the operation of air conditioning units in the Faculty of Science and Technology/UFG (FCT) building. Theoretical Framework: This study …
View article: Increasing the vitamin C transporter SVCT2 in microglia improves synaptic plasticity and restrains memory impairments in Alzheimer’s disease models
Increasing the vitamin C transporter SVCT2 in microglia improves synaptic plasticity and restrains memory impairments in Alzheimer’s disease models Open
Alzheimer’s Disease (AD) is characterized by progressive cognitive decline and synaptic dysfunction, often associated with amyloid-beta accumulation and microglial alterations. Here, we investigate the role of the Sodium-dependent Vitamin …
View article: Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance
Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance Open
Microglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate …
View article: Coordinating energy management systems in smart cities with electric vehicles
Coordinating energy management systems in smart cities with electric vehicles Open
The rapid proliferation of Electric Vehicles (EVs) creates an inherent link between the previously independent transport and power sectors. This is especially relevant in the smart cities paradigm, which focuses on optimizing resource mana…
View article: Rac1 signaling in microglia is essential for synaptic proteome plasticity and experience-dependent cognitive performance
Rac1 signaling in microglia is essential for synaptic proteome plasticity and experience-dependent cognitive performance Open
Microglial homeostatic functions are fundamental to regulate the central nervous system microenvironment. We use conditional cell-specific gene targeting, RNA-seq profiling, high-throughput proteomics, phosphoproteomics, systems biology, a…
View article: Astrocyte-derived TNF and glutamate critically modulate microglia reactivity by methamphetamine
Astrocyte-derived TNF and glutamate critically modulate microglia reactivity by methamphetamine Open
Methamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational purposes. Besides disrupting the monoaminergic system and promoting oxidative brain damage, Meth also causes neuroinflammation that contributes to s…
View article: Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior
Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior Open
Binge drinking may cause anxiety by triggering microglia to destroy excitatory synapses.
View article: Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration Open
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous micro…
View article: Alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior
Alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior Open
Alcohol use adversely impacts the life of millions of people worldwide. Deficits in synaptic transmission and in microglial function are common findings in human alcohol users and in animal models of alcohol intoxication. Here, we show tha…
View article: Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology and leads to neurodegeneration
Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology and leads to neurodegeneration Open
Nervous tissue homeostasis requires regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia…