Tian-Ming Fu
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View article: Material and design strategies for chronically-implantable neural probes
Material and design strategies for chronically-implantable neural probes Open
Implantable neural probes capable of monitoring deep brain activities with single-neuron resolution have contributed substantially to our understanding of brain function, treatment of neurological diseases, and application in brain-machine…
View article: Intravital Multimodal Imaging of Human Cortical Organoids for Chronic Stroke Treatment in Mice
Intravital Multimodal Imaging of Human Cortical Organoids for Chronic Stroke Treatment in Mice Open
Chronic stroke leads to enduring neurological deficits and remains a major clinical challenge. Human induced pluripotent stem cell (hiPSC)-derived cortical organoids (COs) offer promise for regenerative therapies, yet their application in …
View article: A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms
A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms Open
Understanding biological systems requires observing features and processes across vast spatial and temporal scales, spanning nanometers to centimeters and milliseconds to days, often using multiple imaging modalities within complex native …
View article: Image processing tools for petabyte-scale light sheet microscopy data
Image processing tools for petabyte-scale light sheet microscopy data Open
Light sheet microscopy is a powerful technique for high-speed three-dimensional imaging of subcellular dynamics and large biological specimens. However, it often generates datasets ranging from hundreds of gigabytes to petabytes in size fo…
View article: Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity Open
Immune cells have intensely physical lifestyles characterized by structural plasticity and force exertion. To investigate whether specific immune functions require stereotyped mechanical outputs, we used super-resolution traction force mic…
View article: Image processing tools for petabyte-scale light sheet microscopy data
Image processing tools for petabyte-scale light sheet microscopy data Open
Light sheet microscopy is a powerful technique for high-speed 3D imaging of subcellular dynamics and large biological specimens. However, it often generates datasets ranging from hundreds of gigabytes to petabytes in size for a single expe…
View article: Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina
Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina Open
Retinal Müller glia function as injury-induced stem-like cells in zebrafish but not mammals. However, insights gleaned from zebrafish have been applied to stimulate nascent regenerative responses in the mammalian retina. For instance, micr…
View article: Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator
Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator Open
View article: Origin of wiring specificity in an olfactory map revealed by neuron type–specific, time-lapse imaging of dendrite targeting
Origin of wiring specificity in an olfactory map revealed by neuron type–specific, time-lapse imaging of dendrite targeting Open
How does wiring specificity of neural maps emerge during development? Formation of the adult Drosophila olfactory glomerular map begins with the patterning of projection neuron (PN) dendrites at the early pupal stage. To better understand …
View article: Author response: Origin of wiring specificity in an olfactory map revealed by neuron type–specific, time-lapse imaging of dendrite targeting
Author response: Origin of wiring specificity in an olfactory map revealed by neuron type–specific, time-lapse imaging of dendrite targeting Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information …
View article: Origin of wiring specificity in an olfactory map: dendrite targeting of projection neurons
Origin of wiring specificity in an olfactory map: dendrite targeting of projection neurons Open
How does wiring specificity of neural maps emerge during development? Formation of the adult Drosophila olfactory glomerular map begins with patterning of projection neuron (PN) dendrites at the early pupal stage. To better understand the …
View article: A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling
A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling Open
View article: Cellular bases of olfactory circuit assembly revealed by systematic time-lapse imaging
Cellular bases of olfactory circuit assembly revealed by systematic time-lapse imaging Open
View article: Cellular Bases of Olfactory Circuit Assembly Revealed by Systematic Time-lapse Imaging
Cellular Bases of Olfactory Circuit Assembly Revealed by Systematic Time-lapse Imaging Open
Neural circuit assembly features simultaneous targeting of numerous neuronal processes from constituent neuron types, yet the dynamics is poorly understood. Here, we use the Drosophila olfactory circuit to investigate dynamic cellular proc…
View article: Cellular Bases of Olfactory Circuit Assembly Revealed by Systematic Time-Lapse Imaging
Cellular Bases of Olfactory Circuit Assembly Revealed by Systematic Time-Lapse Imaging Open
View article: A Proliferative to Invasive Switch is Mediated by srGAP1 Downregulation Through the Activation of TGFβ2 Signaling
A Proliferative to Invasive Switch is Mediated by srGAP1 Downregulation Through the Activation of TGFβ2 Signaling Open
View article: Advanced One- and Two-Dimensional Mesh Designs for Injectable Electronics
Advanced One- and Two-Dimensional Mesh Designs for Injectable Electronics Open
The unique structure and mechanical properties of syringe-injectable mesh electronics have enabled seamless tissue integration and stable chronic recording of the activities of the same neurons on a year scale. Here, we report studies of a…
View article: Bioinspired neuron-like electronics
Bioinspired neuron-like electronics Open
View article: Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology Open
Implantable brain electrophysiology probes are valuable tools in neuroscience due to their ability to record neural activity with high spatiotemporal resolution from shallow and deep brain regions. Their use has been hindered, however, by …
View article: A method for single-neuron chronic recording from the retina in awake mice
A method for single-neuron chronic recording from the retina in awake mice Open
Eye can see neural activity Organisms take up a tremendous amount of information through the visual system, which is then processed by the neural circuitry. Hong et al. developed a mesh electronics implant that is delivered by injection in…
View article: Highly scalable multichannel mesh electronics for stable chronic brain electrophysiology
Highly scalable multichannel mesh electronics for stable chronic brain electrophysiology Open
Significance Implantable electrical probes have led to fundamental neuroscience advances and treatment of neurological diseases, yet are unable to stably track the long-term evolution of large numbers of individual neurons critical to brai…
View article: Syringe-injectable mesh electronics integrate seamlessly with minimal chronic immune response in the brain
Syringe-injectable mesh electronics integrate seamlessly with minimal chronic immune response in the brain Open
Significance Seamless integration of electrical probes within neural tissue could substantially enhance their impact and open up new opportunities in neuroscience research through electronic therapeutics. This paper describes systematic st…
View article: Bioelectronics: From Nanoscopic Intracellular Probe to Macroscopic Brain-Electronics Interface
Bioelectronics: From Nanoscopic Intracellular Probe to Macroscopic Brain-Electronics Interface Open
The structural and dynamical hierarchies of biological systems, especially the brain, spanning multiple spatiotemporal scales pose great challenges for fundamental research and biomedical study. Bioelectronics-based probes with detection r…
View article: Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes
Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes Open
View article: Syringe-injectable electronics
Syringe-injectable electronics Open
View article: General Strategy for Biodetection in High Ionic Strength Solutions Using Transistor-Based Nanoelectronic Sensors
General Strategy for Biodetection in High Ionic Strength Solutions Using Transistor-Based Nanoelectronic Sensors Open
Transistor-based nanoelectronic sensors are capable of label-free real-time chemical and biological detection with high sensitivity and spatial resolution, although the short Debye screening length in high ionic strength solutions has made…