Nian‐Zhang Zhang
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View article: Transcriptomic Profiling of <scp>mRNAs</scp> , <scp>circRNAs</scp> , and <scp>lncRNAs</scp> in Mouse Liver at the Early Stage of <i>Echinococcus multilocularis</i> Infection
Transcriptomic Profiling of <span>mRNAs</span> , <span>circRNAs</span> , and <span>lncRNAs</span> in Mouse Liver at the Early Stage of <i>Echinococcus multilocularis</i> Infection Open
Alveolar echinococcosis (AE) is a significant zoonotic disease caused by the larval form of Echinococcus multilocularis ( E. multilocularis ), posing substantial health risks. However, the roles of circular RNAs (circRNAs), long non‐coding…
View article: Molecular diagnosis of Trichinella spp.: current status and future prospects
Molecular diagnosis of Trichinella spp.: current status and future prospects Open
Trichinellosis, a significant parasitic zoonotic disease, poses a risk to public health as well as economic implications for the safety of animal feed. Consumption of raw or undercooked meat containing Trichinella larvae can lead to trichi…
View article: The PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii
The PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii Open
Toxoplasma gondii is a significant pathogen in both humans and animals, with disease progression driven by the rapid proliferation of its tachyzoite stage. In this study, we identify the PP2A-2 holoenzyme as a key regulator of daughter cel…
View article: A new intermediate host of Echinococcus shiquicus in Qinghai-Tibet Plateau, China
A new intermediate host of Echinococcus shiquicus in Qinghai-Tibet Plateau, China Open
Echinococcosis is a severe parasitic zoonosis worldwide distribution, caused by the genus Echinococcus. One of its recently identified species, Echinococcus shiquicus, is believed to be endemic to the Qinghai-Tibet plateau in China. Resear…
View article: Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis (Adv. Sci. 18/2025)
Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis (Adv. Sci. 18/2025) Open
Echinococcus Multilocularis In article number 2405914, Wan‐Zhong Jia, Junhua Li, Hong‐Bin Yan, and co‐workers decipher the shift in host (Nezha) immune response strategies from “active killing” to “negative segregation” during Echinococcus…
View article: Whole-genomic comparison reveals complex population dynamics and parasitic adaptation of <i>Echinococcus granulosus sensu stricto</i>
Whole-genomic comparison reveals complex population dynamics and parasitic adaptation of <i>Echinococcus granulosus sensu stricto</i> Open
Cystic echinococcosis (CE), caused by Echinococcus granulosus sensu stricto ( s.s. ), poses a substantial risk to both humans and domestic animals globally. Here, we compared the whole genomes of 111 E. granulosus s.s. samples from China. …
View article: Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis
Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis Open
Alveolar echinococcosis (AE) is caused by the chronic infection of E. multilocularis , whose tumor‐like growth can lead to high fatality if improperly treated. The early diagnosis of infection and the treatment of advanced AE remain challe…
View article: Characterizing Rna Modifications in the Mouse Brain Throughout Acute and Chronic Toxoplasma Gondii Infection
Characterizing Rna Modifications in the Mouse Brain Throughout Acute and Chronic Toxoplasma Gondii Infection Open
View article: Occurrence of <i>Trichinella spiralis</i> in farmed wild boars (<i>Sus scrofa</i>): an underrated risk in China
Occurrence of <i>Trichinella spiralis</i> in farmed wild boars (<i>Sus scrofa</i>): an underrated risk in China Open
Natural infection by Trichinella sp. has been reported in humans and more than 150 species of animals, especially carnivorous and omnivorous mammals. Although the presence of Trichinella sp. infection in wild boars ( Sus scrofa ) has been …
View article: Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis
Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis Open
Alveolar echinococcosis (AE) is caused by the invasive growth of the metacestodes of Echinococcus multilocularis ( E. multilocularis ). The early diagnosis, management, and treatment of AE remains challenging. Herein, we integrated bulk RN…
View article: Biodiversity of Cyclophyllidea species in rodents of western China and the “out of the Qinghai-Tibet Plateu, QTP” hypothesis of this order based on its differentiation and biogeography
Biodiversity of Cyclophyllidea species in rodents of western China and the “out of the Qinghai-Tibet Plateu, QTP” hypothesis of this order based on its differentiation and biogeography Open
The Cyclophyllidea comprise the most species-rich order of tapeworms (Platyhelminthes, Cestoda) with, for helminths, perhaps the most severe health impact on wildlife, livestock, and humans. Rodent biodiversity of the Qinghai-Tibet Plateau…
View article: The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony
The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony Open
Sexual development in Toxoplasma gondii is a multistep process that culminates in the production of oocysts, constituting approximately 50% of human infections. However, the molecular mechanisms governing sexual commitment in this parasite…
View article: Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella
Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella Open
The intracellular protozoan Eimeria tenella is responsible for avian coccidiosis which is characterized by host intestinal damage and death. During developmental cycle, E. tenella undergoes versatile transitional stages such as oocyst, spo…
View article: A Strainer-Based Platform for the Collection and Immunolabeling of Porcine Epidemic Diarrhea Virus-Infected Porcine Intestinal Organoid
A Strainer-Based Platform for the Collection and Immunolabeling of Porcine Epidemic Diarrhea Virus-Infected Porcine Intestinal Organoid Open
The development of organoid research has raised new requirements for this methodology. In a previous study, we demonstrated that an emerging protocol achieved the collection, loading, and programmed immunolabeling of mouse intestinal organ…
View article: Infection of sheep by Echinococcus multilocularis in Gansu, China: evidence from mitochondrial and nuclear DNA analysis
Infection of sheep by Echinococcus multilocularis in Gansu, China: evidence from mitochondrial and nuclear DNA analysis Open
View article: Establishment of a secondary infection laboratory model of <i>Echinococcus shiquicus</i> metacestode using BALB/c mice and Mongolian jirds (<i>Meriones unguiculatus</i>)
Establishment of a secondary infection laboratory model of <i>Echinococcus shiquicus</i> metacestode using BALB/c mice and Mongolian jirds (<i>Meriones unguiculatus</i>) Open
Echinococcus shiquicus is peculiar to the Qinghai–Tibet plateau of China. Research on this parasite has mainly focused on epidemiological surveys and life cycle studies. So far, limited laboratory studies have been reported. Here, experime…
View article: Understanding pathogen–host interplay by expression profiles of lncRNA and mRNA in the liver of Echinococcus multilocularis-infected mice
Understanding pathogen–host interplay by expression profiles of lncRNA and mRNA in the liver of Echinococcus multilocularis-infected mice Open
Almost all Echinococcus multilocularis ( Em ) infections occur in the liver of the intermediate host, causing a lethal zoonotic helminthic disease, alveolar echinococcosis (AE). However, the long non-coding RNAs (lncRNAs) expression profil…
View article: Investigation of Antiparasitic Activity of Two Marine Natural Products, Estradiol Benzoate, and Octyl Gallate, on Toxoplasma gondii In Vitro
Investigation of Antiparasitic Activity of Two Marine Natural Products, Estradiol Benzoate, and Octyl Gallate, on Toxoplasma gondii In Vitro Open
Toxoplasmosis, caused by Toxoplasma gondii , is a common disease worldwide and could be severe and even fatal in immunocompromised individuals and fetuses. Limitation in current available treatment options drives the need to develop novel …
View article: Expansion of Cyclophyllidea Biodiversity in Rodents of Qinghai-Tibet Plateau and the “Out of Qinghai-Tibet Plateau” Hypothesis of Cyclophyllideans
Expansion of Cyclophyllidea Biodiversity in Rodents of Qinghai-Tibet Plateau and the “Out of Qinghai-Tibet Plateau” Hypothesis of Cyclophyllideans Open
The Cyclophyllidea comprises the most species-rich order of tapeworms (Platyhelminthes, Cestoda) and includes species with some of the most severe health impact on wildlife, livestock, and humans. We collected seven Cyclophyllidea specimen…
View article: A systematic review and meta-analysis on prevalence and distribution of Taenia and Echinococcus infections in Ethiopia
A systematic review and meta-analysis on prevalence and distribution of Taenia and Echinococcus infections in Ethiopia Open
Background Tapeworm infections are among the tropical neglected parasitic diseases endemically occurring in Ethiopia. This systematic review and meta-analysis aims at estimating the pooled prevalence and distribution of Taenia and Echinoco…
View article: Comparative Transcriptome Analyses of the Developmental Stages of Taenia multiceps
Comparative Transcriptome Analyses of the Developmental Stages of Taenia multiceps Open
Cerebral coenurosis, caused by the larvae of Taenia multiceps ( Coenurus cerebralis) , is a fatal central nervous system disease in sheep and other herbivores and occasionally humans. Comparative transcriptomic profiles of the developmenta…
View article: Understanding Pathogen-host Interplay by Expression Profiles of LncRNA and mRNA in the Liver of Echinococcus Multilocularis-infected Mice
Understanding Pathogen-host Interplay by Expression Profiles of LncRNA and mRNA in the Liver of Echinococcus Multilocularis-infected Mice Open
Background: Echinococcus multilocularis (Em) infection and the growth and proliferation of its metacestode within the internal organs of hosts are related to complex host–parasite interactions at the molecular level. Previous studies repor…
View article: <i>Echinococcus shiquicus</i> in Qinghai–Tibet plateau: population structure and confirmation of additional endemic areas
<i>Echinococcus shiquicus</i> in Qinghai–Tibet plateau: population structure and confirmation of additional endemic areas Open
Echinococcus shiquicus is currently limited to the Qinghai–Tibet plateau, a large mountainous region in China. Although the zoonotic potential remains unknown, progress is being made on the distribution and intermediate host range. In this…
View article: Genetic Evolution and Implications of the Mitochondrial Genomes of Two Newly Identified Taenia spp. in Rodents From Qinghai-Tibet Plateau
Genetic Evolution and Implications of the Mitochondrial Genomes of Two Newly Identified Taenia spp. in Rodents From Qinghai-Tibet Plateau Open
The larva of Taeniidae species can infect a wide range of mammals, causing major public health and food safety hazards worldwide. The Qinghai-Tibet Plateau (QTP), a biodiversity hotspot, is home to many species of rodents, which act as the…
View article: Primary characterization of the immune responses in Tibetan pigs infected with Chinese Tibet isolate of Trichinella spiralis
Primary characterization of the immune responses in Tibetan pigs infected with Chinese Tibet isolate of Trichinella spiralis Open
Background Trichinellosis, caused by Trichinella spiralis , is a serious foodborne parasitic zoonosis. Tibetan pig is an infrequent, endemic plateau pig species, mainly distributed in Tibet Plateau, China. Because of the free-range system,…
View article: Specific Detection and Differentiation Between Brucella melitensis and Brucella abortus by a Duplex Recombinase Polymerase Amplification Assay
Specific Detection and Differentiation Between Brucella melitensis and Brucella abortus by a Duplex Recombinase Polymerase Amplification Assay Open
Brucellosis is a highly contagious zoonosis caused by a species under the genus Brucella . A duplex recombinase polymerase amplification (Duplex RPA) assay for the specific detection of Brucella melitensis and Brucella abortus was develope…
View article: First report on the phylogenetic relationship, genetic variation of Echinococcus shiquicus isolates in Tibet Autonomous Region, China
First report on the phylogenetic relationship, genetic variation of Echinococcus shiquicus isolates in Tibet Autonomous Region, China Open
View article: Genetic evolution and implications of the mitochondrial genomes of two newly identified Taenia spp. in rodents from Qinghai-Tibet Plateau
Genetic evolution and implications of the mitochondrial genomes of two newly identified Taenia spp. in rodents from Qinghai-Tibet Plateau Open
The larva of Taeniidae species can infect a wide range of mammals, causing major public health and food safety hazards worldwide. The Qinghai-Tibet Plateau (QTP), a biodiversity hotspot, is home to many species of rodents, which act as the…
View article: A new molecular nomenclature for <i>Taenia hydatigena</i>: mitochondrial DNA sequences reveal sufficient diversity suggesting the assignment of major haplotype divisions
A new molecular nomenclature for <i>Taenia hydatigena</i>: mitochondrial DNA sequences reveal sufficient diversity suggesting the assignment of major haplotype divisions Open
Cysticercosis caused by the metacestode larval stage of Taenia hydatigena formerly referred to as Cysticercus tenuicollis is a disease of veterinary importance that constitutes a significant threat to livestock production worldwide, especi…
View article: Trichinella spiralis Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages
Trichinella spiralis Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages Open
Trichinella infection can induce macrophages into the alternatively activated phenotype, which is primarily associated with the development of a polarized Th2 immune response. In the present study, we examined the immunomodulatory e…