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View article: ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke Open
Perioperative stroke is a rare but serious complication with a rising incidence in aging populations. Although preclinical studies consistently demonstrate that anesthetics such as sevoflurane can induce neuroprotective preconditioning aga…
View article: Search for Light Dark Matter with 259 Days of Data in PandaX-4T
Search for Light Dark Matter with 259 Days of Data in PandaX-4T Open
We present a search for light dark matter particles through their interactions with atomic electrons and nucleons, utilizing PandaX-4T data with an effective exposure of 1.04 tonne · year for ionization-only data and 1.20 ton…
View article: METTL3-dependent m6A RNA methylation suppresses aberrant mammary epithelial differentiation and neoplastic transformation
METTL3-dependent m6A RNA methylation suppresses aberrant mammary epithelial differentiation and neoplastic transformation Open
The mechanisms underlying sustained proliferation and aberrant cellular plasticity that drive early breast tumorigenesis remain unclear. Using CRISPR knockout (KO) screens, we systematically characterized the regulators of cellular fitness…
View article: AB‐Panda: An AI‐Generated Antibody Structure‐Based Tool for Developability Prediction
AB‐Panda: An AI‐Generated Antibody Structure‐Based Tool for Developability Prediction Open
The developability of antibodies is a critical concern in antibody discovery, encompassing issues such as self‐interaction, aggregation, and thermal stability. The use of computational and structure‐based tools has greatly improved the eva…
View article: 18F-DOPA uptake illustration acts as an indicator for renal sympathetic activity
18F-DOPA uptake illustration acts as an indicator for renal sympathetic activity Open
Renal denervation (RDN) has emerged as a promising therapeutic approach for hypertension, particularly in patients with refractory hypertension. However, non-invasive measurement of the degree of renal nerve ablation has still been a chall…
View article: Coverage optimization strategy for 3D wireless sensor network based on adaptive inertia weight Arctic Puffin Optimization Algorithm
Coverage optimization strategy for 3D wireless sensor network based on adaptive inertia weight Arctic Puffin Optimization Algorithm Open
A multi-strategy improved Arctic Puffin Optimization Algorithm (CAAPO) based node coverage optimization approach is provided to tackle the problems of unequal node deployment and low coverage in wireless sensor networks (WSNs). Drawing ins…
View article: Effect of the COVID-19 lockdown in Shanghai on maternal and neonatal outcomes
Effect of the COVID-19 lockdown in Shanghai on maternal and neonatal outcomes Open
View article: Longitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer
Longitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer Open
View article: Protective Role of Multiple Essential Minerals Against Cadmium-Related Cognitive Decline in Middle-Aged and Older Adults: A Prospective Study
Protective Role of Multiple Essential Minerals Against Cadmium-Related Cognitive Decline in Middle-Aged and Older Adults: A Prospective Study Open
Background: Cadmium (Cd) exposure is linked to cognitive decline in middle-aged and older adults, but the modifying role of essential minerals is unclear. This study aimed to identify key protective minerals and quantify their joint antago…
View article: The application of thulium laser in combination with holmium laser ablation via flexible ureteroscopy for the treatment of upper urinary tract urothelial carcinoma
The application of thulium laser in combination with holmium laser ablation via flexible ureteroscopy for the treatment of upper urinary tract urothelial carcinoma Open
View article: Radiation-Induced Liver Injury: An Overview
Radiation-Induced Liver Injury: An Overview Open
Radiation therapy is one of the main methods of tumor treatment, with over 50% of patients opting for it during treatment. The optimal regimen of radiation therapy aims to increase the dose in the target area while decreasing the dose in n…
View article: A Quality Control Framework for AI-Based Contouring in Radiotherapy: Clinical Implementation and Validation
A Quality Control Framework for AI-Based Contouring in Radiotherapy: Clinical Implementation and Validation Open
View article: Molecular Epidemiology of SARS-CoV-2 Detected from Different Areas of the Kandy District of Sri Lanka from November 2020–March 2022
Molecular Epidemiology of SARS-CoV-2 Detected from Different Areas of the Kandy District of Sri Lanka from November 2020–March 2022 Open
A comprehensive analysis of the molecular epidemiology of SARS-CoV-2 in the Kandy District of Sri Lanka from November 2020 to March 2022 was conducted to address the limited genomic surveillance data available across the country. The study…
View article: Corrigendum to ‘Oxidized fucoidan-based nanocomposite hydrogel for cryptotanshinone delivery and prevention of postoperative abdominal adhesions’ [Journal of Controlled Release 382 (2025) 113733]
Corrigendum to ‘Oxidized fucoidan-based nanocomposite hydrogel for cryptotanshinone delivery and prevention of postoperative abdominal adhesions’ [Journal of Controlled Release 382 (2025) 113733] Open
View article: Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of kidney function decline: Unraveling the mediating role of iron status
Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of kidney function decline: Unraveling the mediating role of iron status Open
The effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) on kidney function across physiological conditions remain inconclusive, and previous research has not assessed the potential mediating effect of iron status. We aimed to e…
View article: Effect of emotional freedom techniques in mitigating pain catastrophizing following total knee arthroplasty
Effect of emotional freedom techniques in mitigating pain catastrophizing following total knee arthroplasty Open
View article: A review of research progress on the application of bryophytes in the ecological restoration of mining areas of China
A review of research progress on the application of bryophytes in the ecological restoration of mining areas of China Open
The process of mining is invariably associated with ecological and environmental challenges within the mining region, making ecological restoration efforts in these areas especially crucial. Bryophytes, acting as key pioneer species, exhib…
View article: STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis
STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis Open
Pulmonary fibrosis (PF) remains a clinically intractable condition with limited therapies. Ferroptosis has emerged as a critical driver of PF. The previous study demonstrates that increased secretion of tissue plasminogen activator from fe…
View article: Engineering ROS-responsive double network hydrogel as bioactive barrier for postoperative abdominal adhesions prevention
Engineering ROS-responsive double network hydrogel as bioactive barrier for postoperative abdominal adhesions prevention Open
Postoperative adhesions are common and severe complications, which affect up to 90 % of patients undergoing abdominal surgery. Despite the application of various strategies to minimize adhesions, the clinical outcomes remain far from satis…
View article: Annual trends in childhood fracture and injury in Beijing from 2010 to 2019
Annual trends in childhood fracture and injury in Beijing from 2010 to 2019 Open
Beijing children experienced progressively rising fracture and injury rates during the study decade, with notable increases in older age groups. The proportional rise of fracture among injured children suggests changing injury patterns. Wh…
View article: VectorLLM: Human-like Extraction of Structured Building Contours vis Multimodal LLMs
VectorLLM: Human-like Extraction of Structured Building Contours vis Multimodal LLMs Open
Automatically extracting vectorized building contours from remote sensing imagery is crucial for urban planning, population estimation, and disaster assessment. Current state-of-the-art methods rely on complex multi-stage pipelines involvi…
View article: A novel malnutrition assessment model predicts the inflammatory storm of relapsed/refractory acute myeloid leukemia following C-type lectin-like molecule-1 chimeric antigen receptor T therapy
A novel malnutrition assessment model predicts the inflammatory storm of relapsed/refractory acute myeloid leukemia following C-type lectin-like molecule-1 chimeric antigen receptor T therapy Open
Objectives Previous studies have been insufficient in addressing malnutrition in leukemia patients and inflammatory storms following immunotherapy infusion. This study investigates the relationship between malnutrition and inflammatory sto…
View article: Visual analysis of global research on neoadjuvant and adjuvant strategies in NSCLC from 2013 to 2023
Visual analysis of global research on neoadjuvant and adjuvant strategies in NSCLC from 2013 to 2023 Open
View article: Dual-route levofloxacin delivery following revision surgery: a synergistic intravenous/intra-articular strategy for enhanced bactericidal effect against prosthetic Pseudomonas aeruginosa infections
Dual-route levofloxacin delivery following revision surgery: a synergistic intravenous/intra-articular strategy for enhanced bactericidal effect against prosthetic Pseudomonas aeruginosa infections Open
Purpose: Pseudomonas aeruginosa (PA)-associated periprosthetic joint infection (PJI) is notoriously difficult to treat due to biofilm formation and poor antibiotic penetration into joint tissues. This study investigates the efficacy of com…
View article: Novel potential biomarkers for predicting childhood caries via metagenomic analysis
Novel potential biomarkers for predicting childhood caries via metagenomic analysis Open
Background Dental caries is a prevalent global health issue, particularly among children, with significant oral and overall health implications. The oral microbiome is considered a critical factor in caries development, with various microb…
View article: Progress in the study of therapeutic strategies for hepatoblastoma in children
Progress in the study of therapeutic strategies for hepatoblastoma in children Open
Hepatoblastoma (HB) is the most common primary malignant liver tumor in children, representing approximately 50% to 60% of pediatric liver cancers. It predominantly affects children under the age of 3 years, with a slightly higher incidenc…
View article: The global, regional, and national burden of secondhand smoke-related tracheal, bronchus, and lung cancer: Results from the Global Burden of Disease study 2021
The global, regional, and national burden of secondhand smoke-related tracheal, bronchus, and lung cancer: Results from the Global Burden of Disease study 2021 Open
This study describes the disease burden of secondhand smoke-related TBL cancer, emphasizing secondhand smoke is a non-negligible risk factor for TBL cancer. The findings of this study can serve as a basis for formulating targeted tobacco c…
View article: Tertiary lymphoid structures signature predicts prognosis and clinical benefits from neoadjuvant chemotherapy and PD-1 blockade in colorectal adenocarcinoma
Tertiary lymphoid structures signature predicts prognosis and clinical benefits from neoadjuvant chemotherapy and PD-1 blockade in colorectal adenocarcinoma Open
Background: Tertiary lymphoid structures (TLS) are emerging biomarkers for enhanced anti-tumoral immunity and treatment efficacy in colorectal cancer (CRC). This study aimed to develop a CRC-specific TLS signature and evaluate its predicti…
View article: Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids Open
View article: Integrated Transcriptome and Metabolome Analysis Reveals Candidate Genes and Regulatory Pathways Shaping Duck Meat Color
Integrated Transcriptome and Metabolome Analysis Reveals Candidate Genes and Regulatory Pathways Shaping Duck Meat Color Open
Meat color is the most intuitive measure of meat quality and has a significant impact on consumer preference. To explore the molecular mechanisms affecting duck pectoralis meat color, the phenotypic traits of Cherry Valley duck (CV, eight …