Tian Ming Tu
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View article: Putative long-range mossy fiber sprouting and regional hypermetabolic capacity in the hippocampus of patients with mesial temporal lobe epilepsy
Putative long-range mossy fiber sprouting and regional hypermetabolic capacity in the hippocampus of patients with mesial temporal lobe epilepsy Open
Mesial temporal lobe epilepsy (MTLE) is pathologically characterized by neuronal loss in the dentate hilus, CA3 and CA1 regions, and mossy fiber (MF) sprouting into the inner molecular layer (iML). The latter forms aberrant excitatory circ…
View article: Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development
Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development Open
α-Smooth muscle actin (αSMA) is best characterized as the building block of thin filaments in smooth muscle cells. We observed a clear αSMA immunolabeling in adult human hippocampal mossy fibers (MF), prompting us to explore this novel pat…
View article: Single nucleotide polymorphisms in ovarian cancer impacting lipid metabolism and prognosis: an integrated TCGA database analysis
Single nucleotide polymorphisms in ovarian cancer impacting lipid metabolism and prognosis: an integrated TCGA database analysis Open
Ovarian cancer (OC) stands as a formidable adversary among women, remaining a leading cause of cancer-related mortality owing to its aggressive and invasive nature. Investigating prognostic markers intricately linked to OC's molecular path…
View article: Delayed Diagnosis of Constrictive Pericarditis Resulting in Recurrent Heart Failure: A Case Report
Delayed Diagnosis of Constrictive Pericarditis Resulting in Recurrent Heart Failure: A Case Report Open
Constrictive pericarditis can lead to compromised diastolic ventricular filling due to pericardial inflammation and fibrosis. A diagnosis of constrictive pericarditis was established by identifying structural and hemodynamic features throu…
View article: GGC expansions in <i>NOTCH2NLC</i> contribute to Parkinson disease and dopaminergic neuron degeneration
GGC expansions in <i>NOTCH2NLC</i> contribute to Parkinson disease and dopaminergic neuron degeneration Open
Background and purpose The role of GGC repeat expansions within NOTCH2NLC in Parkinson's disease (PD) and the substantia nigra (SN) dopaminergic neuron remains unclear. Here, we profile the NOTCH2NLC GGC repeat expansions in a large cohort…
View article: Predicting Atrial Fibrillation after Ischemic Stroke: Clinical, Genetics, and Electrocardiogram Modelling
Predicting Atrial Fibrillation after Ischemic Stroke: Clinical, Genetics, and Electrocardiogram Modelling Open
Introduction: Detection of atrial fibrillation (AF) is challenging in patients after ischaemic stroke due to its paroxysmal nature. We aimed to determine the utility of a combined clinical, electrocardiographic, and genetic v…
View article: Low incidence of neurological recurrent side-effects following COVID-19 reimmunization
Low incidence of neurological recurrent side-effects following COVID-19 reimmunization Open
Summary Background Individuals who suffered a neurological adverse event after the Coronavirus disease (COVID-19) vaccine could hesitate and defer reimmunization. Aim We examine the risk of recurrence following reimmunization among patient…
View article: <scp>COVID</scp>‐19 <scp>mRNA</scp> vaccine‐associated cerebral venous thrombosis: Rare adverse event or coincidence?
<span>COVID</span>‐19 <span>mRNA</span> vaccine‐associated cerebral venous thrombosis: Rare adverse event or coincidence? Open
Rare cases of cerebral venous thrombosis after COVID-19 mRNA vaccines have been reported in real-world post-vaccination data. As phase 3 clinical mRNA vaccine trials do not aim to and are not sufficiently powered to detect rare adverse eve…
View article: Doublecortin-expressing neurons in human cerebral cortex layer II and amygdala from infancy to 100 year-old
Doublecortin-expressing neurons in human cerebral cortex layer II and amygdala from infancy to 100 year-old Open
A cohort of morphologically heterogenous doublecortin immunoreactive (DCX+) “immature neurons” has been identified in the cerebral cortex largely around layer II and the amygdala largely in the paralaminar nucleus (PLN) among various mamma…
View article: A meta-analysis of extended ECG monitoring in detection of atrial fibrillation in patients with cryptogenic stroke
A meta-analysis of extended ECG monitoring in detection of atrial fibrillation in patients with cryptogenic stroke Open
Objective The aim of this systematic review is to evaluate the various modalities available for extended ECG monitoring in the detection of atrial fibrillation (AF) following a cryptogenic stroke. Methods MEDLINE (Ovid), EMBASE (Ovid), Coc…
View article: Treatment of Primary Aldosteronism and Reversal of Renin Suppression Improves Left Ventricular Systolic Function
Treatment of Primary Aldosteronism and Reversal of Renin Suppression Improves Left Ventricular Systolic Function Open
Introduction Primary aldosteronism (PA) is associated with increased risk of cardiovascular events. However, treatment of PA has not been shown to improve left ventricular (LV) systolic function using the conventional assessment with LV ej…
View article: Acute kidney injury without need for dialysis, incidence, its impact on long-term stroke survival and progression to chronic kidney disease
Acute kidney injury without need for dialysis, incidence, its impact on long-term stroke survival and progression to chronic kidney disease Open
Introduction Patients who had a stroke are at increased risk of sepsis, dehydration and fluctuations in blood pressure, which may result in acute kidney injury (AKI). The impact of AKI on long-term stroke survival has not been studied well…
View article: Primary Aldosteronism More Prevalent in Patients With Cardioembolic Stroke and Atrial Fibrillation
Primary Aldosteronism More Prevalent in Patients With Cardioembolic Stroke and Atrial Fibrillation Open
Background Primary aldosteronism (PA) is the most common cause of secondary hypertension, and patients are at an increased risk of atrial fibrillation (AF) and stroke. We assessed the prevalence of PA in patients with recent stroke. Method…
View article: Incidence of Cerebral Venous Thrombosis Following SARS-CoV-2 Infection vs mRNA SARS-CoV-2 Vaccination in Singapore
Incidence of Cerebral Venous Thrombosis Following SARS-CoV-2 Infection vs mRNA SARS-CoV-2 Vaccination in Singapore Open
The incidence rate of CVT after SARS-CoV-2 infection was significantly higher compared with after mRNA-based SARS-CoV-2 vaccination. CVT remained rare after mRNA-based SARS-CoV-2 vaccines, reinforcing its safety.
View article: <scp>BNT162b2 mRNA SARS‐CoV</scp>‐2 vaccination does not cause upregulation of endothelial activation markers or hypercoagulability: A prospective, <scp>single‐arm</scp>, longitudinal study
<span>BNT162b2 mRNA SARS‐CoV</span>‐2 vaccination does not cause upregulation of endothelial activation markers or hypercoagulability: A prospective, <span>single‐arm</span>, longitudinal study Open
Our findings provide reassuring preliminary data that BNT162b2 vaccination does not result in endothelial activation or a hypercoagulable state. While the definition and mechanism of (vaccine-induced thrombotic thrombocytopenia) VITT is mo…
View article: Burden of informal care in stroke survivors and its determinants: a prospective observational study in an Asian setting
Burden of informal care in stroke survivors and its determinants: a prospective observational study in an Asian setting Open
View article: Hospital-based observational study of neurological disorders in patients recently vaccinated with COVID-19 mRNA vaccines
Hospital-based observational study of neurological disorders in patients recently vaccinated with COVID-19 mRNA vaccines Open
View article: Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics
Doublecortin-Expressing Neurons in Chinese Tree Shrew Forebrain Exhibit Mixed Rodent and Primate-Like Topographic Characteristics Open
Doublecortin (DCX) is transiently expressed in new-born neurons in the subventricular zone (SVZ) and subgranular zone (SGZ) related to adult neurogenesis in the olfactory bulb (OB) and hippocampal formation. DCX immunoreactive (DCX+) immat…
View article: Evidence-Based Updates to Thrombectomy: Targets, New Techniques, and Devices
Evidence-Based Updates to Thrombectomy: Targets, New Techniques, and Devices Open
Endovascular thrombectomy (EVT) has been validated in several randomized controlled trials in recent years for its efficacy in the treatment of acute ischemic strokes (AIS) and is now the standard of care according to international guideli…
View article: Cerebral venous thrombosis post <scp>BNT162b2 mRNA SARS‐CoV</scp>‐2 vaccination: A black swan event
Cerebral venous thrombosis post <span>BNT162b2 mRNA SARS‐CoV</span>‐2 vaccination: A black swan event Open
Covid-19 vaccine associated cerebral venous thrombosis (CVT) are rare adverse events and can be considered as black swan events. "Black swan events", originally described by Nassim N. Taleb in economic theory, are rare, unexpected events w…
View article: Cerebral Venous Thrombosis Associated with COVID-19 Infection: An Observational, Multicenter Study
Cerebral Venous Thrombosis Associated with COVID-19 Infection: An Observational, Multicenter Study Open
Background and Purpose: Coronavirus disease 2019 (COVID-19) has an increased propensity for systemic hypercoagulability and thromboembolism. An association with cerebrovascular diseases, especially cerebral venous thrombosis…
View article: Hemisensory syndrome: Hyperacute symptom onset and age differentiates ischemic stroke from other aetiologies
Hemisensory syndrome: Hyperacute symptom onset and age differentiates ischemic stroke from other aetiologies Open
View article: Acute Ischemic Stroke During the Convalescent Phase of Asymptomatic COVID-2019 Infection in Men
Acute Ischemic Stroke During the Convalescent Phase of Asymptomatic COVID-2019 Infection in Men Open
This case series suggests that the risk for AIS is higher in adults 50 years or younger during the convalescent period of a COVID-19 infection without respiratory symptoms. Acute ischemic stroke could be part of the next wave of complicati…
View article: Role of caregiver factors in outpatient medical follow-up post-stroke: observational study in Singapore
Role of caregiver factors in outpatient medical follow-up post-stroke: observational study in Singapore Open
Background Outpatient medical follow-up post-stroke is not only crucial for secondary prevention but is also associated with a reduced risk of rehospitalization. However, being voluntary and non-urgent, it is potentially determined by both…
View article: Corrigendum to ‘Neurology of COVID-19 in Singapore’ [Journal of the Neurological Sciences Volume 418, 15 November 2020, 117118]
Corrigendum to ‘Neurology of COVID-19 in Singapore’ [Journal of the Neurological Sciences Volume 418, 15 November 2020, 117118] Open
View article: iTRAQ-Based Proteomic Analysis of Dentate Gyrus in Temporal Lobe Epilepsy With Hippocampal Sclerosis
iTRAQ-Based Proteomic Analysis of Dentate Gyrus in Temporal Lobe Epilepsy With Hippocampal Sclerosis Open
Temporal lobe epilepsy (TLE) is the most frequent type of focal epilepsy in adults, typically resistant to pharmacological treatment, and mostly presents with cognitive impairment and psychiatric comorbidities. The most common neuropatholo…
View article: Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review
Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review Open
View article: Stroke rehabilitation use and caregiver psychosocial health profiles in Singapore: A latent profile transition analysis
Stroke rehabilitation use and caregiver psychosocial health profiles in Singapore: A latent profile transition analysis Open
Objectives: To identify and describe caregiver profiles based on their psychosocial health characteristics over a 12-month period and transitions among these profiles, to determine if stroke rehabilitation use at 12-month post-stroke diffe…
View article: Neurology of COVID-19 in Singapore
Neurology of COVID-19 in Singapore Open
View article: Long-Term Trends in Ischemic Stroke Incidence and Risk Factors: Perspectives from an Asian Stroke Registry
Long-Term Trends in Ischemic Stroke Incidence and Risk Factors: Perspectives from an Asian Stroke Registry Open