Tianyu Zhang
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View article: Transcytotic transportation of size-controlled nanocarriers into dystrophic skeletal muscle leads to therapeutic outcome in mice
Transcytotic transportation of size-controlled nanocarriers into dystrophic skeletal muscle leads to therapeutic outcome in mice Open
Duchenne Muscular Dystrophy (DMD) is a lethal muscle-wasting disorder with limited therapeutic options. Although nano drug delivery offers promise, the biodistribution and access routes to dystrophic muscle remain poorly understood. Here w…
View article: Single-cell profiling unveils the immuno-favorable tumor microenvironment remodeling after successful neoadjuvant therapy for advanced gallbladder cancer
Single-cell profiling unveils the immuno-favorable tumor microenvironment remodeling after successful neoadjuvant therapy for advanced gallbladder cancer Open
Background Neoadjuvant treatment has demonstrated clinical benefits in advanced gallbladder cancer (GBC). However, the overall response rate remains suboptimal, and the underlying mechanisms driving treatment efficacy are not fully underst…
View article: Efficient site-specific integration of kilobase-length DNA fragments in plant cells via Kp03 recombinase
Efficient site-specific integration of kilobase-length DNA fragments in plant cells via Kp03 recombinase Open
Targeted insertion of large DNA sequences into plant genomes remains a major challenge in synthetic biology. Here, we evaluate the large serine recombinase Kp03 for site-specific integration of DNA fragments in rice and Arabidopsis. In tra…
View article: Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in <i>Mycobacterium abscessus</i>
Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in <i>Mycobacterium abscessus</i> Open
Synthetic antibiotics, fluoroquinolones (FQs), are extensively important treatment options for fast growing mycobacterial infections. However, their widespread use has led to decreased efficacy due to intrinsic or acquired resistance. FQs …
View article: Contrastive Weak-to-strong Generalization
Contrastive Weak-to-strong Generalization Open
Weak-to-strong generalization provides a promising paradigm for scaling large language models (LLMs) by training stronger models on samples from aligned weaker ones, without requiring human feedback or explicit reward modeling. However, it…
View article: Correlation between serum low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and clinical characteristics of patients with coronary heart disease: a cross-sectional study
Correlation between serum low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and clinical characteristics of patients with coronary heart disease: a cross-sectional study Open
Compared with patients with angina pectoris, a higher LDL/HDL ratio was associated with an increased risk of MI in patients with CHD.
View article: Hybrid enhanced particle swarm optimization for VTOL UAV sliding mode controller: A methodological
Hybrid enhanced particle swarm optimization for VTOL UAV sliding mode controller: A methodological Open
This paper introduces an improved Sliding Mode Controller (SMC) using Hybrid Enhanced Particle Swarm Optimization (HEPSO) for parameter tuning, optimizing c1, c2, η1, and η2. HEPSO integrates adaptive inertia weights (AIW), unified factor …
View article: Antioxidant functionalized double-net/TA dynamic hydrogel promotes cartilage regeneration through stabilization of chondrocyte phenotype
Antioxidant functionalized double-net/TA dynamic hydrogel promotes cartilage regeneration through stabilization of chondrocyte phenotype Open
View article: Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria
Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria Open
View article: Assessment of TB47 as a potential novel therapeutic agent: <i>in vitro</i> and <i>in vivo</i> efficacy against <i>Mycobacterium leprae</i>
Assessment of TB47 as a potential novel therapeutic agent: <i>in vitro</i> and <i>in vivo</i> efficacy against <i>Mycobacterium leprae</i> Open
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and Mycobacterium lepromatosis . The treatment typically involves multidrug therapy comprising dapsone, clofazimine, and rifampicin for 6–12 months. TB47 is a new inhib…
View article: Advances in Genetic Diversity of Germplasm Resources, Origin and Evolution of Turnip Rape (Brassica rapa L.)
Advances in Genetic Diversity of Germplasm Resources, Origin and Evolution of Turnip Rape (Brassica rapa L.) Open
During a prolonged domestication and environmental selection, Brassica rapa has formed diverse morphological types during a cultivation process of up to 8000 years, such as root-type turnips (Brassica rapa var. rapa), leaf-type Chinese cab…
View article: Comprehensive analysis of exosome-related gene signature in multiple myeloma prognosis and immune microenvironment evaluation
Comprehensive analysis of exosome-related gene signature in multiple myeloma prognosis and immune microenvironment evaluation Open
Multiple myeloma (MM) is a genetically complicated plasma cell malignancy characterized by malignant plasma cell proliferation and monoclonal immunoglobulin synthesis. As a disease that remains incurable, enhancing prognostic accuracy is o…
View article: argminCS: Argmin Inference over a Discrete Candidate Set
argminCS: Argmin Inference over a Discrete Candidate Set Open
View article: On the Alkalinity of Solid Catalysts for Transesterification of Dimethyl Carbonate and Ethanol
On the Alkalinity of Solid Catalysts for Transesterification of Dimethyl Carbonate and Ethanol Open
In this study, Mg-Al-Zn, MgO, Al2O3, and ZnO were synthesized via the co-precipitation method and evaluated as catalysts for the transesterification reaction of dimethyl carbonate (DMC) and ethanol. The crystal structure, morphological cha…
View article: Atmospheric chemical processing dictates aerosol aluminum solubility: insights from field measurement at two locations in northern China
Atmospheric chemical processing dictates aerosol aluminum solubility: insights from field measurement at two locations in northern China Open
Deposition of mineral dust aerosol into open oceans significantly impacts marine biogeochemistry and primary production, and the deposition rates can be constrained using widely measured dissolved aluminum (Al) in surface seawater as a tra…
View article: Supplementary material to "Atmospheric chemical processing dictates aerosol aluminum solubility: insights from field measurement at two locations in northern China"
Supplementary material to "Atmospheric chemical processing dictates aerosol aluminum solubility: insights from field measurement at two locations in northern China" Open
View article: The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates
The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates Open
Pyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZAR) primarily related to pncA mutations. However, discordance between phenotypic resistance and conventional pncA-based molecular diagnostics challeng…
View article: Perilipin1 mediates milk fat synthesis in bovine mammary epithelial cells through SREBP1 phosphorylation
Perilipin1 mediates milk fat synthesis in bovine mammary epithelial cells through SREBP1 phosphorylation Open
This study investigates the role of Perilipin1 (PLIN1) in milk fat synthesis in bovine mammary epithelial cells (BMECs) and its regulatory mechanisms, aiming to provide a foundation for improving milk fat content through molecular breeding…
View article: Kinases Associated with Herpes Zoster Virus Infection Unveiled by Phosphoromics Profiling
Kinases Associated with Herpes Zoster Virus Infection Unveiled by Phosphoromics Profiling Open
Notably, kinase-substrate enrichment analysis identified CSNK2A1 and PRKACA as potential response kinases, whereas their transcription and protein levels were experimentally validated to be significantly altered after VZV infection, showin…
View article: Dual Mutations in MSMEG_0965 and MSMEG_1380 Confer High-Level Resistance to Bortezomib and Linezolid by Both Reducing Drug Intake and Increasing Efflux in Mycobacterium smegmatis
Dual Mutations in MSMEG_0965 and MSMEG_1380 Confer High-Level Resistance to Bortezomib and Linezolid by Both Reducing Drug Intake and Increasing Efflux in Mycobacterium smegmatis Open
The emergence of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains poses serious challenges to global tuberculosis control, highlighting the urgent need to elucidate the mechanisms underlying multidrug r…
View article: Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis
Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis Open
The caseinolytic protease (Clp) system has recently emerged as a promising anti-tuberculosis target. The anti-cancer drug bortezomib exhibits potent anti-mycobacterial activity and binds to Mycobacterium tuberculosis ( Mtb ) Clp protease c…
View article: A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in <i>Mycobacterium abscessus</i>
A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in <i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus , a fast‐growing, non‐tuberculous mycobacterium resistant to most antimicrobial drugs, causes a wide range of serious infections in humans, posing a significant public health challenge. The development of effective …
View article: Impact of Cerium Doping on the Osteogenic Properties of a 3D Biomimetic Piezoelectric Scaffold with Sustained Mg2+ Release
Impact of Cerium Doping on the Osteogenic Properties of a 3D Biomimetic Piezoelectric Scaffold with Sustained Mg2+ Release Open
The study demonstrates that Ce doping can significantly enhance the osteogenic properties of WH-based scaffolds, with the optimal Ce/Ca ratio of 0.06 being particularly effective in promoting bone formation. This research provides a promis…
View article: <b>The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in <i>Mycobacterium abscessus</i></b>
<b>The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in <i>Mycobacterium abscessus</i></b> Open
Mycobacterium abscessus (Mab) causes pulmonary diseases with limited treatment options due to its high level of intrinsic resistance to available drugs. Mab possesses complex and poorly understood drug resistance mechanisms. Identifying ne…
View article: Dual Mutations in MSMEG_0965 and MSMEG_1380 Confer High-Level Resistance to Bortezomib and Linezolid by Both Reducing Drug Intake and Increasing Efflux in <em>Mycobacterium smegmatis</em>
Dual Mutations in MSMEG_0965 and MSMEG_1380 Confer High-Level Resistance to Bortezomib and Linezolid by Both Reducing Drug Intake and Increasing Efflux in <em>Mycobacterium smegmatis</em> Open
The emergence of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains poses serious challenges to global tuberculosis control, highlighting the urgent need to unravel the mechanisms underlying multidrug res…
View article: ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity
ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity Open
Inflammation is a crucial element of immune responses, with pivotal roles in host defenses against pathogens. Comprehensive understanding of the molecular mechanisms underlying inflammation is imperative for developing effective strategies…
View article: GrcC1 mediates low-level resistance to multiple drugs in <i>M. marinum</i> , <i>M. abscessus,</i> and <i>M. smegmatis</i>
GrcC1 mediates low-level resistance to multiple drugs in <i>M. marinum</i> , <i>M. abscessus,</i> and <i>M. smegmatis</i> Open
The escalating threat of mycobacterial infectious diseases, particularly those caused by nontuberculous mycobacteria (NTM), poses a serious challenge to public health. Linezolid (LZD), an oxazolidinone antimicrobial, exhibits potent activi…
View article: A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis
A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis Open
The efficacy of many compounds against Mycobacterium tuberculosis is often limited when administered via conventional oral or injection routes due to suboptimal pharmacokinetic characteristics. Inhalation-based delivery methods have been i…
View article: Giant Dentigerous Cyst in a Child Treated with Minimally Modified Invasive Marsupialization and Decompression: A Case Report with 30 months Follow-up
Giant Dentigerous Cyst in a Child Treated with Minimally Modified Invasive Marsupialization and Decompression: A Case Report with 30 months Follow-up Open
Background Dentigerous cysts are a type of inflammatory odontogenic cyst that arises from tissues surrounding an unerupted or impacted tooth. If left untreated, they can grow into a substantial size, resulting in cortical expansion and fac…
View article: Therapeutic Efficacy and Safety Assessment of Hongsheng Dan in Enhancing Healing of Chronic Refractory Wounds in Rats
Therapeutic Efficacy and Safety Assessment of Hongsheng Dan in Enhancing Healing of Chronic Refractory Wounds in Rats Open