Tony Chieh‐Ting Huang
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View article: BYS10, a novel selective RET inhibitor, exhibits potent antitumor activity in preclinical models
BYS10, a novel selective RET inhibitor, exhibits potent antitumor activity in preclinical models Open
Background Aberrant alterations in the RET gene serve as oncogenic drivers in multiple cancers, making RET kinase inhibition a promising therapeutic strategy. However, acquired resistance limits the clinical efficacy of selective RET inhib…
View article: The impact of chest contouring aesthetics outcomes: a pilot eye tracking study
The impact of chest contouring aesthetics outcomes: a pilot eye tracking study Open
Eye-tracking technology was used to assess aesthetic surgical outcomes in transgender and gender diverse patients who are assigned female at birth and who seek gender affirming chest surgery. Post-surgery, observers focused more on scars t…
View article: Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates <i>In Vivo</i> Antitumor Activity
Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates <i>In Vivo</i> Antitumor Activity Open
CD73 (ecto-5'-nucleotidase) has emerged as an attractive target for cancer immunotherapy of many cancers. CD73 catalyzes the hydrolysis of adenosine monophosphate (AMP) into highly immunosuppressive adenosine that plays a critical role in …
View article: Total shoulder arthroplasty versus reverse total shoulder arthroplasty: Outcome comparison in osteoarthritis patients with or without concurrent rotator cuff deficiency
Total shoulder arthroplasty versus reverse total shoulder arthroplasty: Outcome comparison in osteoarthritis patients with or without concurrent rotator cuff deficiency Open
Osteoarthritis (OA) is a common shoulder disorder that impacts shoulder functions. Shoulder arthroplasty is often required to restore function and quality of life. Reverse total shoulder arthroplasty (RSA), which was originally designed ma…
View article: Intrinsic Tendon Regeneration After Application of Purified Exosome Product: An In Vivo Study
Intrinsic Tendon Regeneration After Application of Purified Exosome Product: An In Vivo Study Open
Background: Tendons are primarily acellular, limiting their intrinsic regenerative capabilities. This limited regenerative potential contributes to delayed healing, rupture, and adhesion formation after tendon injury. Purpose: To determine…
View article: The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma
The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma Open
Dysregulated metabolism is a hallmark of cancer that manifests through alterations in bioenergetic and biosynthetic pathways to enable tumor cell proliferation and survival. Tumor cells exhibit high rates of glycolysis, a phenomenon known …
View article: A Stepwise Approach to the “Frozen Neck” for Secondary Microsurgical Reconstruction
A Stepwise Approach to the “Frozen Neck” for Secondary Microsurgical Reconstruction Open
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View article: Total Shoulder Arthroplasty versus Reverse Total Shoulder Arthroplasty: Outcome Comparison in Osteoarthritis patients with or without Concurrent Rotator Cuff Deficiency
Total Shoulder Arthroplasty versus Reverse Total Shoulder Arthroplasty: Outcome Comparison in Osteoarthritis patients with or without Concurrent Rotator Cuff Deficiency Open
BackgroundOsteoarthritis (OA) is a common shoulder disorder that impacts shoulder functions. Shoulder arthroplasty is often required to restore function and quality of life. Reverse total shoulder arthroplasty (RSA), which was originally d…
View article: Repair of severe traumatic nasal alar defects with combined pedicled flap and conchal cartilage composite grafts: a retrospective study
Repair of severe traumatic nasal alar defects with combined pedicled flap and conchal cartilage composite grafts: a retrospective study Open
A pedicled flap combined with conchal composite grafts should be considered for the treatment of severe traumatic alar defect. This is a reproducible technique that enables a predictably decent outcome for severe traumatic alar defect, esp…
View article: 705 Anti-tumor activity of CB-668, a potent, selective and orally bioavailable small-molecule inhibitor of the immuno-suppressive enzyme Interleukin 4 (IL-4)-Induced Gene 1 (IL4I1)
705 Anti-tumor activity of CB-668, a potent, selective and orally bioavailable small-molecule inhibitor of the immuno-suppressive enzyme Interleukin 4 (IL-4)-Induced Gene 1 (IL4I1) Open
Background Tumors evade destruction by the immune system through multiple mechanisms including altering metabolism in the tumor microenvironment. Metabolic control of immune responses occurs through depletion of essential nutrients or accu…
View article: Modified Use of Costal Cartilage in Asians for the Correction of Nostril Asymmetry in Unilateral Secondary Cleft Lip Nasal Deformity
Modified Use of Costal Cartilage in Asians for the Correction of Nostril Asymmetry in Unilateral Secondary Cleft Lip Nasal Deformity Open
Background Weak alar cartilage and lack of soft tissue on the cleft side are considered to be the main critical factors leading to the asymmetry of bilateral nostrils. The costal cartilage can provide strong structural support and can be u…
View article: Single-stage VASER-assisted liposuction and lymphatico-venous anastomoses for the treatment of extremity lymphedema: a case series and systematic review of the literature
Single-stage VASER-assisted liposuction and lymphatico-venous anastomoses for the treatment of extremity lymphedema: a case series and systematic review of the literature Open
Our combined approach is safe surgical option and allows adequate limb size reduction with faster recovery in selected patients with lymphedema with strong fibroadipose component.
View article: Combined microvascular breast and lymphatic reconstruction with deep inferior epigastric perforator flap and gastroepiploic vascularized lymph node transfer for postmastectomy lymphedema patients
Combined microvascular breast and lymphatic reconstruction with deep inferior epigastric perforator flap and gastroepiploic vascularized lymph node transfer for postmastectomy lymphedema patients Open
The combined use of DIEP flap and GE-VLNT flaps in a single-stage procedure is a safe and reliable surgical option for patients with postmastectomy lymphedema who desire and are suitable for autologous microvascular breast and lymphatic re…
View article: Surgical Management of Lower Extremity Lymphedema: A Comprehensive Review
Surgical Management of Lower Extremity Lymphedema: A Comprehensive Review Open
Lymphedema refers to the accumulation of protein-rich fluid in the interstitial spaces. This can occur secondary to congenital malformation of the lymphatic channels or nodes or as a result of an insult that damages appropriately formed ch…
View article: Staged inset of free flaps for complex microsurgical head and neck reconstruction to ensure total flap survival
Staged inset of free flaps for complex microsurgical head and neck reconstruction to ensure total flap survival Open
Introduction Microsurgical reconstruction of complex head and neck defects often requires reliable tissue in multiple spatial configurations to achieve good functional and aesthetic outcomes. In addition to robust perforators, flap inset a…
View article: Compact and Economical Microsurgical Training Made Possible with Virtual Reality
Compact and Economical Microsurgical Training Made Possible with Virtual Reality Open
Sir: Microsurgical proficiency and efficiency require frequent, time-intensive training to develop precise hand-eye coordination and fine motor control. Unfortunately, such training is not readily available to all trainees because of the h…
View article: Abstract: Pudendal Nerve Blocks for Vaginoplasty in Gender Confirmation Surgery
Abstract: Pudendal Nerve Blocks for Vaginoplasty in Gender Confirmation Surgery Open
INTRODUCTION: General (GA) and spinal anesthesia (SA) are common and effective ways to control pain during pelvic surgeries, such as vaginoplasty for gender confirmation surgery (GCS). Many surgeons working in this field are seeking differ…
View article: Abstract: Gender Reassignment Surgery Using the Pedicle Transverse Colon Flap for Vaginal Reconstruction: A Clinical Outcome and Sexual Function Evaluation Study
Abstract: Gender Reassignment Surgery Using the Pedicle Transverse Colon Flap for Vaginal Reconstruction: A Clinical Outcome and Sexual Function Evaluation Study Open
INTRODUCTION: Vaginal reconstruction is indicated in vaginal agenesis, following pelvic tumor resection, trauma and for sexual-reassignment surgery. Different surgical options have been described for vaginal reconstruction. Herein, we pres…
View article: Abstract: Complications and Patient Reported Outcomes in Male to Female Vaginoplasty Where We Are Today a Systematic Review and Meta Analysis
Abstract: Complications and Patient Reported Outcomes in Male to Female Vaginoplasty Where We Are Today a Systematic Review and Meta Analysis Open
PURPOSE: There is an increased need for evidence-based practices in male to female transgender (MtF) vaginoplasty. While there are a multitude of surgical techniques, there is a paucity of data comparing these procedures. A systematic revi…
View article: Abstract: Analysis of 30 Day Mortality after Free Flap Reconstructions for Head and Neck Cancer Patients: A Propensity-Score Matched Analysis of a Nationwide, Population-Based Cohort Study
Abstract: Analysis of 30 Day Mortality after Free Flap Reconstructions for Head and Neck Cancer Patients: A Propensity-Score Matched Analysis of a Nationwide, Population-Based Cohort Study Open
INTRODUCTION: Thirty-day postoperative mortality is the principal index for assessing operative outcomes,1, 2 and has been infrequently examined in reconstructive microsurgery for head and neck cancer (HNC) patients. The aims of this study…
View article: Abstract: Erogenous Sensate Vaginal Flap for Male to Female Vaginoplasty
Abstract: Erogenous Sensate Vaginal Flap for Male to Female Vaginoplasty Open
PURPOSE: The lack of erogenous sensitivity in the neo-vagina is one of the major shortcomings for patients undergoing male to female genital confirmation surgery. A clitoral flap derived from the glans penis serves as the only source of er…
View article: Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer
Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer Open
Purpose: Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC) is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH). However, the contribution of L-2-HG to renal carcinogenesis and insight into the bioch…
View article: Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment Open
These results demonstrate that Arg1 is a key mediator of immune suppression and that inhibiting Arg1 with CB-1158 shifts the immune landscape toward a pro-inflammatory environment, blunting myeloid cell-mediated immune evasion and reducing…