Tao Zhang
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View article: Isotope Variability in Summer Precipitation under the Compound Effects of Moisture Source Conversion and Local Meteorological Dynamics in the Yellow River Delta, North China
Isotope Variability in Summer Precipitation under the Compound Effects of Moisture Source Conversion and Local Meteorological Dynamics in the Yellow River Delta, North China Open
Hydrogen and oxygen stable isotopes serve as essential tracers for deciphering atmospheric circulation patterns and driving mechanisms of extreme climatic events. However, their utility in high-resolution climate reconstruction remains con…
View article: Improving T cell expansion by optogenetically engineered bacteria-loaded MMP-2-responsive cyclophosphamide for antitumor immunotherapy
Improving T cell expansion by optogenetically engineered bacteria-loaded MMP-2-responsive cyclophosphamide for antitumor immunotherapy Open
The efficacy of antitumor immunotherapy is closely associated with the expansion of tumor-infiltrating CD8+ T cells. However, within the tumor microenvironment, CD8+ T cells often exhibit reduced proliferation due to …
View article: Draft genome sequence of <i>Enterococcus gallinarum</i> strain TY-1 isolated from human saliva
Draft genome sequence of <i>Enterococcus gallinarum</i> strain TY-1 isolated from human saliva Open
We report the draft genome sequence of Enterococcus gallinarum strain TY-1 isolated from human saliva in China. The genome is 3.4 Mb in size with a G + C content of 40.5 % and encodes 3,150 predicted proteins, seven rRNAs, 56 tRNAs, four n…
View article: SmaAt-UNet Optimized by Particle Swarm Optimization (PSO): A Study on the Identification of Detachment Diseases in Ming Dynasty Temple Mural Paintings in North China
SmaAt-UNet Optimized by Particle Swarm Optimization (PSO): A Study on the Identification of Detachment Diseases in Ming Dynasty Temple Mural Paintings in North China Open
The temple mural paintings of the Ming Dynasty in China are highly valuable cultural heritage. However, murals in North China have long faced deterioration such as pigment-layer detachment, which seriously threatens their preservation and …
View article: Intratumoral plasma cells predict patient prognosis and responsiveness to neoadjuvant immunotherapy in advanced gastric cancer
Intratumoral plasma cells predict patient prognosis and responsiveness to neoadjuvant immunotherapy in advanced gastric cancer Open
View article: Circulating tumor DNA refines consolidation immunotherapy for limited-stage small cell lung cancer patients
Circulating tumor DNA refines consolidation immunotherapy for limited-stage small cell lung cancer patients Open
View article: Electro-activated nanozyme for in situ tumor vaccination: Synergistic multi-enzyme catalysis and electrodynamic therapy
Electro-activated nanozyme for in situ tumor vaccination: Synergistic multi-enzyme catalysis and electrodynamic therapy Open
View article: Environmental cadmium exposure promotes lung cancer via DHX34: A molecular toxicology perspective
Environmental cadmium exposure promotes lung cancer via DHX34: A molecular toxicology perspective Open
Although cadmium (Cd) exposure has been implicated in lung cancer development, systematic investigations into its association with cancer mortality, particularly lung cancer mortality remain limited, and the molecular mechanisms driving Cd…
View article: The efficacy and safety of disitamab vedotin combined with immune checkpoint inhibitors in metastatic upper tract urothelial carcinoma: a multicenter real-world study
The efficacy and safety of disitamab vedotin combined with immune checkpoint inhibitors in metastatic upper tract urothelial carcinoma: a multicenter real-world study Open
View article: Case Report: Psychogenic purpura in a uremic patient on peritoneal dialysis
Case Report: Psychogenic purpura in a uremic patient on peritoneal dialysis Open
Psychogenic purpura (Gardner-Diamond syndrome) is a rare autoimmune vasculopathy characterized by the spontaneous onset of painful edema and infiltrative cutaneous lesions that rapidly develop into ecchymosis after severe psychological str…
View article: Ole-e-1 Interacts with FWL Genes to Modulate Cell Division and Determine Fruit Size in Pears
Ole-e-1 Interacts with FWL Genes to Modulate Cell Division and Determine Fruit Size in Pears Open
The fw2.2 (fruit weight 2.2) gene negatively regulates cell division and significantly influences fruit size, but its regulatory mechanisms in pears remain unclear. Here, we investigated how pear FWL (fw2.2-like) genes control cell divisio…
View article: Fractional flow reserve calculation optimized by myocardial computed tomography perfusion information
Fractional flow reserve calculation optimized by myocardial computed tomography perfusion information Open
The computed fluid dynamics calculation, guided by MBF values from stress CTP imaging, helps enhance the consistency between CT-FFR calculation and invasive fractional flow reserve measurements.
View article: Robot-assisted augmented reality navigation for osteotomy and personalized guide-plate in mandibular reconstruction: a preclinical study
Robot-assisted augmented reality navigation for osteotomy and personalized guide-plate in mandibular reconstruction: a preclinical study Open
View article: Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study
Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study Open
Our study confirmed the relationship between serum phosphate and CKD-aP within the past 3 months, to some extent explaining the controversy generated by previous studies. These results may help clinicians better understand the relationship…
View article: A nomogram for predicting the risk of chemoradiotherapy-associated thrombocytopenia in patients with esophageal cancer: a real-world cohort study
A nomogram for predicting the risk of chemoradiotherapy-associated thrombocytopenia in patients with esophageal cancer: a real-world cohort study Open
Background: Thrombocytopenia is a common hematological toxicity in esophageal cancer (EC) patients receiving radiation therapy. Objectives: The purpose of this study was to construct and validate a nomogram for predicting the incidence of …
View article: Therapeutic potential of mesenchymal stem cell exosomes for tumors in the digestive system: From bench to bedside
Therapeutic potential of mesenchymal stem cell exosomes for tumors in the digestive system: From bench to bedside Open
Exosomes are small, bilayer lipid vesicles with diameters ranging from approximately 40–160 nm. These vesicles carry a diverse array of molecular cargo, including DNA, RNA, lipids, and proteins, which play a critical role in intercel…
View article: Quercetin targets the Ccl4–Ccr5 axis to relieve neuropathic pain after spinal cord injury
Quercetin targets the Ccl4–Ccr5 axis to relieve neuropathic pain after spinal cord injury Open
Spinal cord injury (SCI) severely disrupts the central nervous system, with neuropathic pain (NP) emerging as a prevalent and challenging complication, affecting approximately two-thirds of affected individuals. This study aims to explore …
View article: Multifunctional investigation of “drug–excipient unification” of natural polysaccharide nanocarriers: A new paradigm from drug delivery to adjuvant therapy
Multifunctional investigation of “drug–excipient unification” of natural polysaccharide nanocarriers: A new paradigm from drug delivery to adjuvant therapy Open
View article: Endothelial cell-secreted bone targeting exosomes promote angiogenesis coupling with osteogenesis via the PERK-ATF4-CRELD2 pathway
Endothelial cell-secreted bone targeting exosomes promote angiogenesis coupling with osteogenesis via the PERK-ATF4-CRELD2 pathway Open
View article: Bioinformatics and experimental unveiling of TIMP1 as a novel therapeutic target in colorectal cancer ferroptosis
Bioinformatics and experimental unveiling of TIMP1 as a novel therapeutic target in colorectal cancer ferroptosis Open
Introduction Colorectal cancer (CRC) remains a globally prevalent and lethal malignancy, with ferroptosis emerging as a novel cell death mechanism. This study aimed to elucidate the role of key genes in ferroptosis regulation and their imp…
View article: Plasma miR-378a as a novel biomarker for the early detection of colon cancer
Plasma miR-378a as a novel biomarker for the early detection of colon cancer Open
Introduction: Prognosis and treatment outcomes of colon cancer (CC) patients are poor due to the limitations of the current early diagnostic techniques. Recently, innovations in liquid biopsy technology have inspired research into identify…
View article: Single-cell and spatial transcriptomics profile the interaction of SPP1+ macrophages and FAP+ fibroblasts in non-small cell lung cancer
Single-cell and spatial transcriptomics profile the interaction of SPP1+ macrophages and FAP+ fibroblasts in non-small cell lung cancer Open
SPP1 ranks as the top DEG in NSCLC tumor attributed to its specific expression in SPP1 + macrophages, proportion of which increases in tumor and interact with FAP + fibroblasts. Their interactions…
View article: Electric fields trigger ceramide-dependent budding of exosome vesicles into multivesicular endosomes and boost the generation of exosomes
Electric fields trigger ceramide-dependent budding of exosome vesicles into multivesicular endosomes and boost the generation of exosomes Open
Exosomes hold immense therapeutic and diagnostic potential, yet their clinical translation remains constrained by low yields. Physiological electric fields (EFs), naturally occurring during wound healing and embryo development, have unexpl…
View article: A DNA Methylation–LDHA–Deoxycarnitine Regulatory Axis Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma
A DNA Methylation–LDHA–Deoxycarnitine Regulatory Axis Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma Open
Background: Clear cell renal cell carcinoma (ccRCC) is the predominant histological subtype of renal cancer, characterized by high recurrence and metastasis rates. Despite advances in targeted therapies, treatment resistance and poor progn…
View article: CYTO-SV-ML: A Machine Learning Tool for Cytogenetic Structural Variant Analysis in Somatic Cell Type Using Genome Sequences
CYTO-SV-ML: A Machine Learning Tool for Cytogenetic Structural Variant Analysis in Somatic Cell Type Using Genome Sequences Open
(1) Background: Although whole genome sequencing (WGS) has enabled the comprehensive analyses of structural variants (SVs), more accurate and efficient methods are needed to distinguish large somatic SVs (SV size ≥ 1 Mb) traditionally dete…
View article: Lobectomy versus sub-lobar resection for special type non-small cell lung cancer ≤2 cm
Lobectomy versus sub-lobar resection for special type non-small cell lung cancer ≤2 cm Open
In early-stage ST-NSCLC ≤2 cm, lobectomy is associated with better survival outcomes than sub-lobar resection for LCC, LCNEC, ASC, and SC, highlighting the role of tumor histology in surgical decisions. For MC, sub-lobar resection appears …
View article: A case report of advanced EML4-ALK fusion pulmonary sarcomatoid carcinoma
A case report of advanced EML4-ALK fusion pulmonary sarcomatoid carcinoma Open
View article: Analysis of the current situation and risk factors of nosocomial infections in oral cancer patients after surgery
Analysis of the current situation and risk factors of nosocomial infections in oral cancer patients after surgery Open
Oral cancer surgery patients are at high risk of infection, and targeted monitoring of oral cancer surgery patients should be strengthened. Preventive measures should be taken for risk factors to reduce nosocomial infection rates.
View article: Cooperative Causal GraphSAGE
Cooperative Causal GraphSAGE Open
GraphSAGE is a widely used graph neural network. The introduction of causal inference has improved its robust performance and named as Causal GraphSAGE. However, Causal GraphSAGE focuses on measuring causal weighting among individual nodes…
View article: Definitive chemoradiotherapy combined with anti-PD-1 immunotherapy for inoperable esophageal squamous cell carcinoma: a multicenter real-world study
Definitive chemoradiotherapy combined with anti-PD-1 immunotherapy for inoperable esophageal squamous cell carcinoma: a multicenter real-world study Open
Trial no. NCT04821778 registered in ClinicalTrials.gov.