Tiandao Li
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View article: A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes Open
The antigenic landscape of autoimmune diabetes reflects a failure to preserve self-tolerance, yet how novel neoantigens emerge in humans remains incompletely understood. Here we designed an immunopeptidomics-based approach to probe HLA-II-…
View article: Contribution of Sex‐Biased Expressed Genes in Osteoarthritis
Contribution of Sex‐Biased Expressed Genes in Osteoarthritis Open
Human osteoarthritis (OA) displays sex‐specific patterns in its clinical presentation. Key features of the disease—such as prevalence, age of onset, progression, and response to treatment—vary between males and females. These differences h…
View article: Proliferation of Early and Mature Osteoblasts Is Required for Bone Fracture Healing in Mice
Proliferation of Early and Mature Osteoblasts Is Required for Bone Fracture Healing in Mice Open
Fractures heal by rapid formation of mineralized callus. Essential to this process is proliferation of periosteal cells to supply bone-forming osteoblasts. To better understand the role of cell proliferation in fracture healing, we asked: …
View article: Regulation of the Yolk Microtubule and Actin Cytoskeleton by Dachsous Cadherins during Zebrafish Epiboly
Regulation of the Yolk Microtubule and Actin Cytoskeleton by Dachsous Cadherins during Zebrafish Epiboly Open
Epiboly is a crucial morphogenetic process during early animal embryogenesis that expands surface area of embryonic tissues while thinning them. During zebrafish development, epiboly spreads the superficial enveloping layer (EVL), germ lay…
View article: Endothelial <i>Cept1</i> Promotes Post-Ischemic Angiogenesis in a <i>Pparα</i>-Dependent Fashion
Endothelial <i>Cept1</i> Promotes Post-Ischemic Angiogenesis in a <i>Pparα</i>-Dependent Fashion Open
Background Cept1 is essential for de novo phopholipogenesis and is impacted by diabetes. We previously demonstrated that conditional knockdown of Cept1 in the endothelium leads to reduced hindlimb angiogenesis and tissue recovery. We hypot…
View article: A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes Open
The evolving antigenic landscape of autoimmune diabetes reflects a dynamic failure to preserve self-tolerance. Yet, how novel neoantigens emerge in humans remains incompletely understood. Here, we designed an immunopeptidomics-based approa…
View article: Crinophagic granules in pancreatic β cells contribute to mouse autoimmune diabetes by diversifying pathogenic epitope repertoire
Crinophagic granules in pancreatic β cells contribute to mouse autoimmune diabetes by diversifying pathogenic epitope repertoire Open
Autoimmune attack toward pancreatic β cells causes permanent loss of glucose homeostasis in type 1 diabetes (T1D). Insulin secretory granules store and secrete insulin but are also thought to be tissue messengers for T1D. Here, we show tha…
View article: SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis
SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis Open
View article: Review and Evaluate the Bioinformatics Analysis Strategies of ATAC-seq and CUT&Tag Data
Review and Evaluate the Bioinformatics Analysis Strategies of ATAC-seq and CUT&Tag Data Open
Efficient and reliable profiling methods are essential to study epigenetics. Tn5, one of the first identified prokaryotic transposases with high DNA-binding and tagmentation efficiency, is widely adopted in different genomic and epigenomic…
View article: Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects
Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects Open
Critical size bone defects represent a significant challenge worldwide, often leading to persistent pain and physical disability that profoundly impact patients' quality of life and mental well-being. To address the intricate and complex r…
View article: CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity
CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity Open
View article: Symptomatic Benign Prostatic Hyperplasia with Suppressed Epigenetic Regulator HOXB13 Shows a Lower Incidence of Prostate Cancer Development
Symptomatic Benign Prostatic Hyperplasia with Suppressed Epigenetic Regulator HOXB13 Shows a Lower Incidence of Prostate Cancer Development Open
Our objective was to identify variations in gene expression that could help elucidate the pathways for the development of prostate cancer (PCa) in men with Benign Prostatic Hyperplasia (BPH). We included 98 men with BPH, a positive prostat…
View article: DNA methylation–mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation
DNA methylation–mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation Open
Challenging skeletal repairs are frequently seen in patients experiencing systemic inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we performed single-cell RNA sequencing and revealed that progenito…
View article: MORA and EnsembleTFpredictor: An ensemble approach to reveal functional transcription factor regulatory networks
MORA and EnsembleTFpredictor: An ensemble approach to reveal functional transcription factor regulatory networks Open
Motivation Our study aimed to identify biologically relevant transcription factors (TFs) that control the expression of a set of co-expressed or co-regulated genes. Results We developed a fully automated pipeline, M otif O ver R epresentat…
View article: Author Correction: Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer
Author Correction: Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer Open
View article: Genetic characterization of primary and metastatic high-grade serous ovarian cancer tumors reveals distinct features associated with survival
Genetic characterization of primary and metastatic high-grade serous ovarian cancer tumors reveals distinct features associated with survival Open
View article: Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor
Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor Open
View article: Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer
Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer Open
View article: Supplemental Video 2 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Supplemental Video 2 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer Open
Supplemental Video KO Cells
View article: Supplementary Table 2 from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Supplementary Table 2 from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms Open
Exome sequencing results.
View article: Supplementary Figures from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Supplementary Figures from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms Open
Supplementary Figures 1-7
View article: Data from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Data from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer Open
Activating protein 2 alpha (AP-2α; encoded by TFAP2A) functions as a tumor suppressor and influences response to therapy in several cancer types. We aimed to characterize regulation of the transcriptome by AP-2α in colon cancer. CRI…
View article: Data from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Data from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer Open
Activating protein 2 alpha (AP-2α; encoded by TFAP2A) functions as a tumor suppressor and influences response to therapy in several cancer types. We aimed to characterize regulation of the transcriptome by AP-2α in colon cancer. CRI…
View article: Supplemental Video 2 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Supplemental Video 2 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer Open
Supplemental Video KO Cells
View article: Supplemental Video 1 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Supplemental Video 1 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer Open
Supplemental Video 1 Parental Cells
View article: Supplementary Table 2 from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Supplementary Table 2 from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms Open
Exome sequencing results.
View article: Supplementary Figures from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Supplementary Figures from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms Open
Supplementary Figures 1-7
View article: Data from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Data from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms Open
Myeloproliferative neoplasms (MPN) are chronic blood diseases with significant morbidity and mortality. Although sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a signi…
View article: Supplementary Table 1 from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Supplementary Table 1 from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms Open
Hematological comparison of MF patients versus PDXs
View article: Supplemental Figures 1-6 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Supplemental Figures 1-6 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer Open
S1. Confirmation of AP-2α expression. S2. Comparative growth of parental and KO clones. S3. FACS Analysis of Apoptotic Cells with TFAP2AKO. S4. AP-2α binding site. S5. Colon cancer tissue microarray analysis (TMA). S6. TFAP2Aand TGM2 Expre…