Tianyou Yang
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View article: The NSUN5 gene rs1880948 A>G polymorphism and neuroblastoma risk in Chinese children
The NSUN5 gene rs1880948 A>G polymorphism and neuroblastoma risk in Chinese children Open
Background Neuroblastoma (NB) is the most common extracranial solid tumor in children. The 5-methylcytosine (m5C) modification gene NSUN5 polymorphisms may serve as promising molecular markers for identifying populations susceptible to NB.…
View article: Senescence-driven osteonecrosis of the femoral head in the elderly—a distinct pathophysiological entity
Senescence-driven osteonecrosis of the femoral head in the elderly—a distinct pathophysiological entity Open
This article conceptualizes “Senescence-Driven Osteonecrosis of the Femoral Head” in elderly patients as a distinct pathophysiological entity, differing from classic osteonecrosis of the femoral head (ONFH) by its primary age-related etiol…
View article: High prevalence and multifactorial risks of sarcopenia in knee osteoarthritis: a systematic review and meta-analysis
High prevalence and multifactorial risks of sarcopenia in knee osteoarthritis: a systematic review and meta-analysis Open
Sarcopenia and sarcopenic obesity are highly prevalent in patients with KOA and are significantly associated with disease severity, gender, geographic region, comorbidities, and lifestyle factors. These findings highlight the clinical impo…
View article: Asxl2-Deficiency Impairs Pdlscs Osteogenesis Via Epigenetic Reprogramming
Asxl2-Deficiency Impairs Pdlscs Osteogenesis Via Epigenetic Reprogramming Open
Aim or purpose: This study clarifies the epigenetic role of ASXL2 in the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) to resolve critical gaps in craniofacial regeneration mechanisms. Materials and methods:…
View article: Development and validation of radiomics model for MRI-based identification of anterior talofibular ligament injuries
Development and validation of radiomics model for MRI-based identification of anterior talofibular ligament injuries Open
Anterior talofibular ligament (ATFL) injuries are common ankle injuries that require accurate grading for effective treatment planning. However, conventional diagnostic methods, including manual MRI interpretation, often lack objectivity a…
View article: Clinical evaluation of blood flow in femoral head necrosis using color doppler ultrasound
Clinical evaluation of blood flow in femoral head necrosis using color doppler ultrasound Open
This study aims to utilize Color Doppler Ultrasound to collect blood flow parameters of the medial circumflex femoral artery and explore the changes in blood flow in osteonecrosis of the femoral head, providing objective indicators for cli…
View article: Knowledge mapping of core decompression in osteonecrosis of the femoral head: a bibliometric analysis
Knowledge mapping of core decompression in osteonecrosis of the femoral head: a bibliometric analysis Open
Background: Osteonecrosis of the femoral head (ONFH), caused by disrupted blood supply leading to bone cell death and joint collapse, remains a critical orthopedic challenge. While core decompression has advanced significantly in ONFH trea…
View article: CT Hounsfield units in assessing bone and soft tissue quality in the proximal femur: A systematic review focusing on osteonecrosis and total hip arthroplasty
CT Hounsfield units in assessing bone and soft tissue quality in the proximal femur: A systematic review focusing on osteonecrosis and total hip arthroplasty Open
Background Computed tomography (CT) Hounsfield Units (HU) offer valuable insights into the changes in bone and soft tissue densities, playing a crucial role in the diagnosis and management of various proximal femur conditions. This systema…
View article: Lentinan suppresses the progression of neuroblastoma by inhibiting FOS-mediated transcription activation of VRK1 to stabilize p53 protein
Lentinan suppresses the progression of neuroblastoma by inhibiting FOS-mediated transcription activation of VRK1 to stabilize p53 protein Open
Neuroblastoma (NB) is a common malignant and solid pediatric tumor with unfavorable prognosis. Although studies have shown the anti-tumor efficacy of lentinan (LNT), molecular mechanism that contribute to the anti-tumor effect on NB remain…
View article: Polymorphisms in the <i>NSUN1</i> gene and neuroblastoma risk in Chinese children from Jiangsu province
Polymorphisms in the <i>NSUN1</i> gene and neuroblastoma risk in Chinese children from Jiangsu province Open
Neuroblastoma is the most prevalent extracranial solid tumor among children and exhibits remarkable heterogeneity. The methylation of cytosine to form 5-methylcytosine (m5C) is the primary type of modification found in DNA and RNA. The NOL…
View article: Malignant transformation and tumour recurrence in sacrococcygeal teratoma: a global, retrospective cohort study
Malignant transformation and tumour recurrence in sacrococcygeal teratoma: a global, retrospective cohort study Open
Introduction: Sacrococcygeal teratoma (SCT) is a rare congenital tumour. The risk of malignancy and recurrence is not well defined. Previous studies are small and report differing conclusions about the timing of surgery and the duration of…
View article: CD20highCD138low tumor-infiltrating lymphocytes predominantly related to cytokine‒cytokine receptor interactions are associated with favorable outcomes in neuroblastoma patients
CD20highCD138low tumor-infiltrating lymphocytes predominantly related to cytokine‒cytokine receptor interactions are associated with favorable outcomes in neuroblastoma patients Open
Recent advances have revealed that the role of the immune system is prominent in the antitumor response. In the present study, it is aimed to provide an expression profile of tumor-infiltrating lymphocytes (TILs), including mature B cells,…
View article: Functional polymorphisms of the <i>TET1</i> gene increase the risk of neuroblastoma in Chinese children
Functional polymorphisms of the <i>TET1</i> gene increase the risk of neuroblastoma in Chinese children Open
Common genetic mutations are absent in neuroblastoma, one of the most common childhood tumours. As a demethylase of 5‐methylcytosine (m5C) modification, TET1 plays an important role in tumourigenesis and differentiation. However, the assoc…
View article: Investigation of the accuracy of magnetic resonance cholangiography and multi-slice spiral computed tomography in the diagnosis of cholangiocarcinoma
Investigation of the accuracy of magnetic resonance cholangiography and multi-slice spiral computed tomography in the diagnosis of cholangiocarcinoma Open
MRCP can provide relevant imaging feature information, improve the accuracy, sensitivity and specificity of the diagnosis of bile duct carcinoma, and has a high detection rate for small diameter lesions, which has good reference, promotion…
View article: The opportunities and challenges for nutritional intervention in childhood cancers
The opportunities and challenges for nutritional intervention in childhood cancers Open
Diet dictates nutrient availability in the tumor microenvironment, thus affecting tumor metabolic activity and growth. Intrinsically, tumors develop unique metabolic features and are sensitive to environmental nutrient concentrations. Tumo…
View article: PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression
PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression Open
The recurrence and metastasis of children with mediastinal neuroblastoma (NB) are also occurred after surgery, chemotherapy, or radiotherapy. Strategies targeting the tumor microenvironment have been reported to improve survival; however, …
View article: Clinical Application of Indocyanine Green Fluorescence Imaging in the Resection of Hepatoblastoma: A Single Institution's Experiences
Clinical Application of Indocyanine Green Fluorescence Imaging in the Resection of Hepatoblastoma: A Single Institution's Experiences Open
Purpose Indocyanine green (ICG) fluorescence imaging is becoming increasingly popular in adult oncologic surgery, but remains relatively uncommon in pediatric oncologic surgery. Herein, we report our experience with the use of ICG fluoresc…
View article: YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study
YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study Open
Neuroblastoma is a primary malignancy mainly occurring in children. We have reported that polymorphisms of several N6-methyladenosine (m6A) RNA modification-related genes contributed to neuroblastoma risk in previous studies. YTHDF2, a “re…
View article: Table of contents
Table of contents Open
The interplay between the awareness-based resource allocation and epidemic spreading
View article: Association between lncRNA‐<i>H19</i> polymorphisms and hepatoblastoma risk in an ethic Chinese population
Association between lncRNA‐<i>H19</i> polymorphisms and hepatoblastoma risk in an ethic Chinese population Open
H19 polymorphisms are associated with increased susceptibility to several cancers; however, their role in hepatoblastoma remains unclear. In this study, we investigated the association between three H19 polymorphisms (rs2839698 G>A, rs3024…
View article: <i>lncRNA-uc003opf.1</i> rs11752942 A>G polymorphism decreases neuroblastoma risk in Chinese children
<i>lncRNA-uc003opf.1</i> rs11752942 A>G polymorphism decreases neuroblastoma risk in Chinese children Open
Recent studies have revealed that long non-coding RNAs (lncRNAs) play critical roles in the tumorigenesis and proliferation of human cancer. Several polymorphisms of lncRNAs have been found to be involved in the risk of neuroblastoma (NB).…
View article: Staged resection of a bilateral thoracic and bilateral adrenal neuroblastoma
Staged resection of a bilateral thoracic and bilateral adrenal neuroblastoma Open
Neuroblastoma is the most common extracranial solid tumor in childhood. However, ganglioneuroma (GN) and ganglioneuroblastoma intermixed (GNBI), are considerably rare. Herein, we reported a rare case of bilateral thoracic and adrenal GN an…
View article: Analysis of Clinical Characteristics, Pathological Changes and Changes of Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Children with Castleman’s Disease
Analysis of Clinical Characteristics, Pathological Changes and Changes of Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Children with Castleman’s Disease Open
BACKGROUND The aim of this study was to analyze the pathological changes, clinical characteristics and changes in immunity, interleukin-6 (IL-6) and C-reactive protein (CRP) in children with Castleman's disease (CD). MATERIAL AND METHODS A…
View article: Outcomes of children with hepatoblastoma who underwent liver resection at a tertiary hospital in China: a retrospective analysis
Outcomes of children with hepatoblastoma who underwent liver resection at a tertiary hospital in China: a retrospective analysis Open
Background To report the outcomes of hepatoblastoma resected in our institution. Methods We diagnosed 135 children with hepatoblastoma at our institution between January 2010 and December 2017. Patients who underwent liver resection were i…
View article: Outcomes of children with hepatoblastoma who underwent liver resection at a tertiary hospital in China: A retrospective analysis
Outcomes of children with hepatoblastoma who underwent liver resection at a tertiary hospital in China: A retrospective analysis Open
Background : To report the outcomes of hepatoblastoma resected in our institution. Methods: We diagnosed 135 children with hepatoblastoma at our institution between January 2010 and December 2017. Patients who underwent liver resection wer…