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View article: Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer
Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer Open
View article: Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines
Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines Open
View article: Palmitic Acid Exerts Anti-Tumorigenic Activities by Modulating Cellular Stress and Lipid Droplet Formation in Endometrial Cancer
Palmitic Acid Exerts Anti-Tumorigenic Activities by Modulating Cellular Stress and Lipid Droplet Formation in Endometrial Cancer Open
Epidemiological and clinical evidence have extensively documented the role of obesity in the development of endometrial cancer. However, the effect of fatty acids on cell growth in endometrial cancer has not been widely studied. Here, we r…
View article: Palmitic Acid Exerts Anti-Tumorigenic Activities by Modulating Cellular Stress and Lipid Droplet Formation in Endometrial Cancer
Palmitic Acid Exerts Anti-Tumorigenic Activities by Modulating Cellular Stress and Lipid Droplet Formation in Endometrial Cancer Open
Epidemiological and clinical evidence have extensively documented the role of obesity in the development of endometrial cancer. However, the effect of fatty acids on cell growth in endometrial cancer has not been widely studied. Here, we r…
View article: Linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cells and a transgenic model of endometrial cancer
Linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cells and a transgenic model of endometrial cancer Open
Emerging evidence has provided considerable insights into the integral function of reprogramming fatty acid metabolism in the carcinogenesis and progression of endometrial cancer. Linoleic acid, an essential fatty acid with the highest con…
View article: Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells
Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells Open
Proinflammatory cytokines, which are elevated during inflammation or infections, can affect drug pharmacokinetics (PK) due to the altered expression or activity of drug transporters and/or metabolizing enzymes. To date, such studies have f…
View article: Palmitic Acid Inhibits Cell Proliferation and Tumor Growth of Endometrial Cancer In Vitro and In Vivo
Palmitic Acid Inhibits Cell Proliferation and Tumor Growth of Endometrial Cancer In Vitro and In Vivo Open
Epidemiological and clinical evidence have extensively documented the role of obesity in the develop-ment of endometrial cancer. However, the effect of fatty acids on cell growth in endometrial cancer has not been widely studied. Here we r…
View article: Oleic Acid Exhibits Anti-Proliferative and Anti-Invasive Activities via the PTEN/AKT/mTOR Pathway in Endometrial Cancer
Oleic Acid Exhibits Anti-Proliferative and Anti-Invasive Activities via the PTEN/AKT/mTOR Pathway in Endometrial Cancer Open
Reprogramming of fatty acid metabolism promotes cell growth and metastasis through a variety of processes that stimulate signaling molecules, energy storage, and membrane biosynthesis in endometrial cancer. Oleic acid is one of the most im…
View article: Oleic Acid Exhibits Anti-Proliferative and Anti-Invasive Activities via the PTEN/AKT/mTOR Pathway in Endometrial Cancer
Oleic Acid Exhibits Anti-Proliferative and Anti-Invasive Activities via the PTEN/AKT/mTOR Pathway in Endometrial Cancer Open
Reprogramming of fatty acid metabolism promotes cell growth and metastasis through a variety of processes that stimulate signaling molecules, energy storage, and membrane biosynthesis in endometrial cancer. Oleic acid is one of the most im…
View article: Ipatasertib exhibits anti‑tumorigenic effects and enhances sensitivity to paclitaxel in endometrial cancer <i>in vitro</i> and <i>in vivo</i>
Ipatasertib exhibits anti‑tumorigenic effects and enhances sensitivity to paclitaxel in endometrial cancer <i>in vitro</i> and <i>in vivo</i> Open
Endometrial cancer is the most common gynecologic cancer and one of the only cancers for which incidence and mortality is steadily increasing. Although curable with surgery in the early stages, endometrial cancer presents a significant cli…
View article: Regulation of Hepatic Drug Transporters by Pro-inflammatory Cytokines
Regulation of Hepatic Drug Transporters by Pro-inflammatory Cytokines Open
View article: A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer
A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer Open
Poly ADP-ribose polymerase (PARP) inhibitors are effective therapies for cancer patients with homologous recombination (HR) deficient tumors. The imipridone ONC206 is an orally bioavailable dopamine receptor D2 antagonist and mitochondrial…
View article: Asparagus officinalis combined with paclitaxel exhibited synergistic anti-tumor activity in paclitaxel-sensitive and -resistant ovarian cancer cells
Asparagus officinalis combined with paclitaxel exhibited synergistic anti-tumor activity in paclitaxel-sensitive and -resistant ovarian cancer cells Open
Purpose Although paclitaxel is a promising first-line chemotherapeutic drug for ovarian cancer, acquired resistance to paclitaxel is one of the leading causes of treatment failure, limiting its clinical application. Asparagus officinalis h…
View article: Ipatasertib, an oral AKT inhibitor, inhibits cell proliferation and migration, and induces apoptosis in serous endometrial cancer.
Ipatasertib, an oral AKT inhibitor, inhibits cell proliferation and migration, and induces apoptosis in serous endometrial cancer. Open
Ipatasertib (IPAT) is an orally administered, selective protein kinase B (AKT) inhibitor with promising data in solid tumors in both pre-clinical studies and clinical trials. Given that the PI3K/AKT/mTOR pathway is frequently dysregulated …
View article: Contrastive Proposal Extension with LSTM Network for Weakly Supervised Object Detection
Contrastive Proposal Extension with LSTM Network for Weakly Supervised Object Detection Open
Weakly supervised object detection (WSOD) has attracted more and more attention since it only uses image-level labels and can save huge annotation costs. Most of the WSOD methods use Multiple Instance Learning (MIL) as their basic framewor…
View article: Asparagus officinalis Exhibits Anti-Tumorigenic and Anti-Metastatic Effects in Ovarian Cancer
Asparagus officinalis Exhibits Anti-Tumorigenic and Anti-Metastatic Effects in Ovarian Cancer Open
Ovarian cancer is one of the leading causes of female cancer death. Emerging evidence suggests that many dietary natural products have anti-tumorigenic activity, including that of asparagus officinalis. The current study aimed to assess th…
View article: Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer
Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer Open
View article: Additional file 1 of Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer
Additional file 1 of Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer Open
Additional file 1.
View article: Additional file 2 of Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer
Additional file 2 of Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer Open
Additional file 2.
View article: Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer
Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer Open
BackgroundONC201 is a dopamine receptor D2 (DRD2) antagonist that inhibits tumor growth in preclinical models through ClpP activation to induce integrated stress response pathway and mitochondrial events related to inhibition of cell growt…