Tianru Jin
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View article: Glucagon-like peptide-1 receptor agonists as potential preventive and therapeutic agents in ischemic stroke
Glucagon-like peptide-1 receptor agonists as potential preventive and therapeutic agents in ischemic stroke Open
Stroke remains a significant contributor to mortality and morbidity worldwide, imposing a significant socioeconomic burden and underscoring the urgent need for both preventative and therapeutic strategies. Glucagon-like peptide-1 receptor …
View article: Current understanding and controversy on brain access of GLP-1 and GLP-1 receptor agonists
Current understanding and controversy on brain access of GLP-1 and GLP-1 receptor agonists Open
For more than two decades, peripheral administration of GLP-1 or GLP-1 receptor (GLP-1R) agonist (GLP-1RA) curbs appetite and reduce body weight gain in animal models. More importantly, the body weight lowering effect has been effectively …
View article: Resveratrol Intervention Exerts Beneficial Metabolic Effects in High Fat Diet-Challenged Middle-Aged Female Mice Involving Hepatic FGF21
Resveratrol Intervention Exerts Beneficial Metabolic Effects in High Fat Diet-Challenged Middle-Aged Female Mice Involving Hepatic FGF21 Open
View article: Supplementation of mixed Lactobacillus alleviates metabolic impairment, inflammation, and dysbiosis of the gut microbiota in an obese mouse model
Supplementation of mixed Lactobacillus alleviates metabolic impairment, inflammation, and dysbiosis of the gut microbiota in an obese mouse model Open
Introduction Obesity is a complex metabolic disease, which is often accompanied with impaired glucose and lipid metabolism and chronic inflammation. Probiotics have been considered as a strategy for treating obesity, while the genus of Lac…
View article: Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice
Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice Open
We conclude that hepatic FGF21 is required for curcumin or resveratrol in exerting their major metabolic beneficial effect. The recognition that FGF21 as the common target of dietary intervention, demonstrated in current as well as previou…
View article: International Accolades for GLP-1 Research: Recognizing Pioneers in Diabetes and Obesity Treatment Across Five Prestigious Awards
International Accolades for GLP-1 Research: Recognizing Pioneers in Diabetes and Obesity Treatment Across Five Prestigious Awards Open
View article: Hormone based therapy and crosstalk beyond hormones
Hormone based therapy and crosstalk beyond hormones Open
View article: Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice
Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice Open
Conclusion and significance: We conclude that hepatic FGF21 is required for curcumin or resveratrol in exerting their major metabolic beneficial effect. The recognition that FGF21 as the common target of dietary interventions brings us a n…
View article: Hepatic function of glucagon-like peptide-1 and its based diabetes drugs
Hepatic function of glucagon-like peptide-1 and its based diabetes drugs Open
Incretins are gut-produced peptide-hormones that potentiate insulin secretion, especially after food intake. The concept of incretin was formed more than 100 years ago, even before insulin was isolated and utilized in the treatment of subj…
View article: Erratum to: A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope
Erratum to: A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope Open
View article: Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1
Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1 Open
Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I)…
View article: Short‐term semaglutide treatment improves <scp>FGF21</scp> responsiveness in primary hepatocytes isolated from high fat diet challenged mice
Short‐term semaglutide treatment improves <span>FGF21</span> responsiveness in primary hepatocytes isolated from high fat diet challenged mice Open
Metabolic functions of GLP‐1 and its analogues have been extensively investigated. In addition to acting as an incretin and reducing body weight, we and others have suggested the existence of GLP‐1/fibroblast growth factor 21 (FGF21) axis …
View article: Commentary: Can FXR serve as a potential target for COVID-19 prevention?
Commentary: Can FXR serve as a potential target for COVID-19 prevention? Open
View article: An evaluation of the accuracy of toric intraocular lens power calculation based on measured total corneal refractive power
An evaluation of the accuracy of toric intraocular lens power calculation based on measured total corneal refractive power Open
Purpose: To evaluate a method using measured values of total corneal refractive power (TCRP) for a manufacturer’s online calculator by comparing it with the Barrett toric calculator (BTC) and Kane toric calculator (KTC) combined with simul…
View article: untargeted metabolomics analysis of fecal extract after resveratrol treatment
untargeted metabolomics analysis of fecal extract after resveratrol treatment Open
In a previous study, we found that resveratrol could inhibit chylomicron secretion and jejunal SR-B1 expression, and the effects were mediated by gut microbiota and some heat-stable metabolites in the feces of mice which received resveratr…
View article: Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1
Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1 Open
Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I)…
View article: Dietary resveratrol intervention improves lipid homeostasis via attenuating HFD-induced fecal chenodeoxycholic acid and jejunum SR-B1 elevation
Dietary resveratrol intervention improves lipid homeostasis via attenuating HFD-induced fecal chenodeoxycholic acid and jejunum SR-B1 elevation Open
Two common features of dietary polyphenols have hampered our mechanistic understanding of their metabolic beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol interventi…
View article: Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next
Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next Open
Dietary interventions include the change of dietary styles, such as fasting and dietary or nutrient restrictions; or the addition of plant-derived compounds (such as polyphenols known as curcumin, resveratrol, or anthocyanin, or other nutr…
View article: The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs—Therapeutic potential exploration in lung injury
The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs—Therapeutic potential exploration in lung injury Open
Since 2005, GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) have been developed as therapeutic agents for type 2 diabetes (T2D). GLP-1R is not only expressed in pancreatic islets but also other organs, especially the lung. However, controversy…
View article: Liraglutide stimulates the β-catenin signaling cascade in mouse epididymal fat tissue
Liraglutide stimulates the β-catenin signaling cascade in mouse epididymal fat tissue Open
Although canonical Wnt signaling pathway activation was shown to negatively regulate adipogenesis, recent investigations suggest that Wnt pathway effectors TCF7L2 and β-catenin (β-cat) in adipose tissues are also involved in energy homeost…
View article: The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs -- Therapeutic potential exploration in lung injury
The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs -- Therapeutic potential exploration in lung injury Open
Since 2005, GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) have been developed as therapeutic agents for Type 2 diabetes. GLP-1R is not only expressed in pancreatic islets but also in other organs, especially the lung. Extra-pancreatic expres…
View article: Hepatic hormone FGF21 and its analogues in clinical trials
Hepatic hormone FGF21 and its analogues in clinical trials Open
Fibroblast growth factor 21 (FGF21) is a fasting or stress inducible metabolic hormone produced mainly in the liver. It plays important roles in regulating both glucose and lipid homeostasis via interacting with a heterodimeric receptor co…
View article: Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy
Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy Open
View article: Friend or foe? ACE2 inhibitors and GLP-1R agonists in COVID-19 treatment
Friend or foe? ACE2 inhibitors and GLP-1R agonists in COVID-19 treatment Open
View article: Glucagon-like peptide-1 receptor mediates the beneficial effect of liraglutide in an acute lung injury mouse model involving the thioredoxin-interacting protein
Glucagon-like peptide-1 receptor mediates the beneficial effect of liraglutide in an acute lung injury mouse model involving the thioredoxin-interacting protein Open
Repurposing clinically used drugs is among the important strategies in drug discovery. Glucagon-like peptide-1 (GLP-1) and its diabetes-based drugs, such as liraglutide, possess a spectrum of extra-pancreatic functions, while GLP-1 recepto…
View article: GABA requires GLP-1R to exert its pancreatic function during STZ challenge
GABA requires GLP-1R to exert its pancreatic function during STZ challenge Open
Gamma-aminobutyric acid (GABA) administration attenuates streptozotocin (STZ)-induced diabetes in rodent models with unclear underlying mechanisms. We found that GABA and Sitagliptin possess additive effect on pancreatic β-cells, which pro…
View article: Letter to the editor: Comment on GLP-1-based drugs and COVID-19 treatment
Letter to the editor: Comment on GLP-1-based drugs and COVID-19 treatment Open
View article: Dietary Cyanidin-3-Glucoside Attenuates High-Fat-Diet–Induced Body-Weight Gain and Impairment of Glucose Tolerance in Mice via Effects on the Hepatic Hormone FGF21
Dietary Cyanidin-3-Glucoside Attenuates High-Fat-Diet–Induced Body-Weight Gain and Impairment of Glucose Tolerance in Mice via Effects on the Hepatic Hormone FGF21 Open
The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism Open
View article: Novel GLP-1 Analog Supaglutide Stimulates Insulin Secretion in Mouse and Human Islet Beta-Cells and Improves Glucose Homeostasis in Diabetic Mice
Novel GLP-1 Analog Supaglutide Stimulates Insulin Secretion in Mouse and Human Islet Beta-Cells and Improves Glucose Homeostasis in Diabetic Mice Open
Glucagon-like peptide-1 (GLP-1), an incretin hormone plays an important role in regulating glucose homeostasis. The therapeutic use of native GLP-1 is inadequate due to its short in vivo half-life. We recently developed a novel GLP-…