Explanipedia

UACER: An Uncertainty-Aware Critic Ensemble Framework for Robust Adversarial Reinforcement Learning Open

Jiaxi Wu, Tiantian Zhang, Yuxing Wang, Yongzhe Chang, Xueqian Wang · 2025

Robust adversarial reinforcement learning has emerged as an effective paradigm for training agents to handle uncertain disturbance in real environments, with critical applications in sequential decision-making domains such as autonomous dr…

Antiplatelet therapy in anticoagulated cirrhotic patients with chronic portal vein thrombosis: A retrospective multicenter study Open

Tiantian Zhang, Andrew M. Harrison, P. Maheshwari, Aaron Chesterman, M Rampal · 2025

Background: Treatment of chronic portal vein thrombosis (PVT) in cirrhotic patients can be complicated, mainly because there is no clear consensus or solid evidence to guide therapy. Clinicians struggle to strike the right balance between …

In Situ Engineering of Tumor Cells as Self‐Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy Open

Shuiling Jin, Xiaoxi Wang, Bingyu Li, Xueqin Zhu, Zimai Liu , et al. · 2025

Conventional type 1 dendritic cells (cDC1s) play a crucial role in initiating and regulating antitumor immunity. However, the insufficient infiltration and dysfunctional state of these cells within the tumor microenvironment hinder antitum…

Automatic diagnosis of coronary artery stenosis by deep learning based on X-ray coronary angiography Open

Chengyu Mao, Huasu Zeng, Kandi Zhang, Zhang Shi-sheng, Dongjiu Li , et al. · 2025

We introduce an image-based vascular analysis method that localizes and grades stenosis in X-ray coronary angiography. This method can automatically identify clinically critical grades, especially within the 71-100% range. Deep learning me…

Clinical efficacy evaluation of washed microbiota transplantation treatment for metabolic related fatty liver disease and its impact on tongue coating microorganisms Open

Leaf Huang, Siqi Wang, Hao Zhang, Shuo Feng, Haojie Zhong , et al. · 2025

Objective The present study aims to explore the impact of washed microbiota transplantation (WMT) on the tongue microbiota composition of individuals with metabolic-associated fatty liver disease (MAFLD) and elucidate its biological correl…

Reinforcement Learning Meets Masked Generative Models: Mask-GRPO for Text-to-Image Generation Open

Yifu Luo, Xinhao Hu, Kexing Fan, Haoyuan Sun, Zeyu Chen , et al. · 2025

Reinforcement learning (RL) has garnered increasing attention in text-to-image (T2I) generation. However, most existing RL approaches are tailored to either diffusion models or autoregressive models, overlooking an important alternative: m…

Viral Infection of Macrophage Polarization in Porcine Alveolar Macrophages: Mechanisms and Therapeutic Interventions Open

Tiantian Zhang · 2025

The functional polarization of macrophages into pro-inflammatory M1 or anti-inflammatory M2 phenotypes is a critical battleground in host-virus interactions. This review systematically analyzes the mechanisms whereby porcine viruses (PRRSV…

From “lysosomal addiction” to targeted therapies: exploiting novel windows in colorectal cancer Open

Xiaoyu Wang, Fan An, Benjun Wang, Tiantian Zhang, Yu-Ann Fang , et al. · 2025

Patients with advanced-stage or treatment-resistant colorectal cancer (CRC) face limited therapeutic options with conventional therapies, necessitating novel treatment strategies. CRC cells exhibit "lysosomal addiction" through enhanced au…

Evaluation of NEUROG1 methylation status in stool specimens in the advanced adenomas and colorectal cancer Open

Lijin Zhang, Aiping Lin, Jie Lin, Juan Chen, Mengshi Chen , et al. · 2025

Background To assess the status of NEUROG1 methylation in the advanced adenoma and colorectal cancer. Methods The NEUROG1 methylation in tissue and stool samples from patients with colorectal cancer (CRC), advanced adenoma (AA), and non-ad…

Immune cells: the key mediator between the gut microbiota and osteoporosis Open

Tianyi Ma, Tiantian Zhang, C. L. Peng, Peng Liu, Yixiao Xiong , et al. · 2025

As the body’s largest immunological interface, the intestine harbors a complex ecosystem of gut microbiota (GM) that orchestrates mucosal immune maturation while sustaining local immunological equilibrium. Emerging evidence reveals the gut…

Sea cucumber female gonad peptides improve bone metabolism in postmenopausal osteoporosis mice by activating muscle AMPK/FNDC5 signaling mediated irisin secretion Open

Meng C. Wang, Zhibing Leng, Yanzi Liu, Yi Shao, Taher Abdelnaby , et al. · 2025

Correction: Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG Open

Jing Liu, Wenqi Li, Ran Jiao, Zhigang Liu, Tiantian Zhang , et al. · 2025

Rank-Induced PL Mirror Descent: A Rank-Faithful Second-Order Algorithm for Sleeping Experts Open

Tiantian Zhang · 2025

We introduce a new algorithm, \emph{Rank-Induced Plackett--Luce Mirror Descent (RIPLM)}, which leverages the structural equivalence between the \emph{rank benchmark} and the \emph{distributional benchmark} established in \citet{BergamOzcan…

Yttrium-90 selective internal radiation therapy for right hepatic malignancies: a clinical outcome study Open

Xin Huang, Yong Liao, Ziwei Liang, Junpeng Ma, Bin Liang , et al. · 2025

Impact of Thermal Processing Procedures on Technological Properties and Nutritional Value of Sea Cucumber Open

Abdelrahman S. Talab, Ahmed A. Hussein, Hala Ghannam, Tiantian Zhang · 2025

Controlling Twisted Angles in Directly Grown MoS <sub>2</sub> Bilayers via Tilt Grain Boundary Engineering Open

Xiaotian Li, Xuan Zhao, Luneng Zhao, Junfeng Gao, Zihan Zhao , et al. · 2025

The moiré superlattices have garnered significant attention due to their unique twist‐angle‐dependent electronic and optical properties. Creating high‐quality twisted bilayer structures stands as one of the major frontiers in the study of …

Decoding the role of gut mycobiota in immune regulation and disease Open

Tiantian Zhang, Feifan Guo, Chengfei Zhang, Yan Xiang · 2025

The gut mycobiota, a minor but influential component of the microbiota, is increasingly recognized for its role in shaping host immunity and influencing health. Advances in sequencing technologies have now highlighted the diversity and com…

Diabetes is causally associated with increased breast cancer mortality by inducing FIBCD1 to activate MCM5-mediated cell cycle arrest via modulating H3K27ac Open

Binbin Tan, Yang Liu, Qianqian Chen, Weijie Yang, Wenhan Yang , et al. · 2025

Breast cancer (BC) is the most common tumor worldwide and it has been recognized that up to one third of BC patients have co-existing diabetes mellitus (DM) (BC-DM). Although many observational studies have indicated an association between…

Real‐Time Prediction of Overpressure‐Induced Pipeline Failure via Edge‐Optimized Machine Learning Open

Sihang Chen, Zhang Na, Biyuan Shui, Tiantian Zhang, Chunman Li , et al. · 2025

This study proposes a machine learning‐based framework for dynamic overpressure risk prediction in gas–liquid pipelines, addressing the limitations of traditional hydraulic models in real‐time operational scenarios. Unlike conventional phy…

The protective effects of sea cucumber male gonad peptides against testicular damage and spermatogenesis disorder in male mice Open

Lianfeng Yu, Meng C. Wang, Shanshan Guo, Yujin Li, Linyi Zhou , et al. · 2025

Reinforcement Fine-Tuning Powers Reasoning Capability of Multimodal Large Language Models Open

Haoyuan Sun, Jiaqi Wu, Bo Xia, Yifu Luo, Yifei Zhao , et al. · 2025

Standing in 2025, at a critical juncture in the pursuit of Artificial General Intelligence (AGI), reinforcement fine-tuning (RFT) has demonstrated significant potential in enhancing the reasoning capability of large language models (LLMs) …

Novel exosome-associated LncRNA model predicts colorectal cancer prognosis and drug response Open

Chi Zhou, Qian Qiu, Xinyu Liu, Tiantian Zhang, Leilei Liang , et al. · 2025

Background Exosomes are extracellular vesicles that carry various biological substances and have potential as functional mediators in cancers. However, little is known about special molecules in colorectal cancer (CRC) exosomes and their i…

Yttrium-90 Selective Internal Radiation Therapy for Right Hepatic Malignancies: A Clinical Outcome Study Open

Xin Huang, Yong Liao, Ziwei Liang, Junpeng Ma, Bin Liang , et al. · 2025

Background: Surgical resection offers long-term survival for liver malignancies, but insufficient future liver remnant (FLR) volume often precludes operability. This study evaluated yttrium-90 selective internal radiation therapy (^90<…

Correction: Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice Open

Tongtong Xue, Qianyi Zhang, Tiantian Zhang, L. Meng, Jing Liu , et al. · 2025

The sialylation pattern of dietary glycopeptides is vital for inhibiting pathogens and modulating gut microbiota in elderly individuals Open

Jiao Zhu, Tiantian Zhang, Jianrong Wu, Hongtao Zhang · 2025

N-glycosylation is a post-translational modification of proteins that can influence the structure and function of glycoproteins. Edible bird’s nest (EBN) contains highly sialylated mucins with N-glycans and O-glycans, while casein glycomac…

A case of hemichorea-hemiballismus secondary to a subacute hemorrhage in a patient with essential thrombocythemia: a case report Open

Anil Harrison, Tiantian Zhang, Gary Batra · 2025

Does Ownership Structure Influence the Financial Performance of Chinese Listed Companies? An Analysis of ESG Practices and Accounting-Based Outcomes Open

Janet Zhu, Rong Li, Z. Q. Chen, Tiantian Zhang · 2025

This study explores the following two aspects: (i) the impact of Environmental, Social, and Governance (ESG) scores and corporate ownership characteristics on the performance of Chinese listed companies, and (ii) whether different ownershi…

An epitranscriptomic program maintains skeletal stem cell quiescence via a METTL3-FEM1B-GLI1 axis Open

Jing Wang, Weidong Liu, Tiantian Zhang, Manman Cui, Kexin Gao , et al. · 2025

Skeletal stem cells (SSCs) maintain the skeletal system via pluripotency and differentiation capacity. However, it remains largely unknown how these cells precisely regulate their function to maintain skeletal organization. Here, we deline…

Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG Open

Jing Liu, Wenqi Li, Ran Jiao, Zhigang Liu, Tiantian Zhang , et al. · 2025

Multiple large language models versus experienced physicians in diagnosing challenging cases with gastrointestinal symptoms Open

Xintian Yang, Tongxin Li, Handong Wang, Rongchun Zhang, Zhi Ni , et al. · 2025

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