Tianxin Xiang
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View article: Disease burden of interstitial lung disease and pulmonary sarcoidosis from 1992 to 2021 and prediction of future disease burden trend in China
Disease burden of interstitial lung disease and pulmonary sarcoidosis from 1992 to 2021 and prediction of future disease burden trend in China Open
This study highlights the growing ILD and PS burden in China from 1992 to 2021 and anticipates further rises in cases and fatalities over the next decade, even as prevalence rates are expected to stabilize. Age remains a key risk factor.
View article: The IL-33/ST2 Axis Promotes Post-COVID-19 Pulmonary Fibrosis Through β-catenin/PPAR-γ-mediated Epithelial-Mesenchymal Transition
The IL-33/ST2 Axis Promotes Post-COVID-19 Pulmonary Fibrosis Through β-catenin/PPAR-γ-mediated Epithelial-Mesenchymal Transition Open
Background Post-COVID-19 pulmonary fibrosis (PCPF) presents an increasingly significant public health challenge. Although fibrotic mechanisms in PCPF are extensively studied, their exact pathogenesis remains unresolved. Interleukin-33 (IL-…
View article: The Evolution of Virulence of Carbapenem-Resistant Klebsiella pneumoniae from the Same Source Under the Pressure of Omadacycline Treatment
The Evolution of Virulence of Carbapenem-Resistant Klebsiella pneumoniae from the Same Source Under the Pressure of Omadacycline Treatment Open
To sum up, these findings suggest that under the therapeutic stress of omadacycline, CRKP may adjust virulence through adaptive evolution, and the terw gene may be the key factor for the differences in virulence within this bacteria…
View article: Avian influenza virus dynamics in poultry and the environment: an eight-year longitudinal study in the southwestern Poyang Lake region of China
Avian influenza virus dynamics in poultry and the environment: an eight-year longitudinal study in the southwestern Poyang Lake region of China Open
View article: Diagnosing pulmonary MALT lymphoma: a case of unilateral cystic lesions
Diagnosing pulmonary MALT lymphoma: a case of unilateral cystic lesions Open
We present an atypical case of a 62-year-old female diagnosed with pulmonary mucosa-associated lymphoid tissue (p-MALT) lymphoma, which uniquely manifested as a singular cystic lesion in the lung. Diagnostic evaluations, including comprehe…
View article: Spatial and temporal distribution patterns and factors influencing hepatitis B in China: a geo-epidemiological study
Spatial and temporal distribution patterns and factors influencing hepatitis B in China: a geo-epidemiological study Open
View article: Capture of mobile genetic elements following intercellular conjugation promotes the production of ST11-KL64 CR-hvKP
Capture of mobile genetic elements following intercellular conjugation promotes the production of ST11-KL64 CR-hvKP Open
Sequence type (ST)11 carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) can cause life-threatening infections and is therefore of global concern. Despite its importance, the evolutionary history and mechanism for the emerge…
View article: Dabie bandavirus and Mycoplasma pneumoniae co-infection: a case report
Dabie bandavirus and Mycoplasma pneumoniae co-infection: a case report Open
We firstly reported a case with DBV and MP coinfection, which reminded us that the symptoms of DBV infection were bewildering and easy to miss diagnosis when it was co-infection with other etiologies.
View article: Biochemical properties and substrate specificity of GOB-38 in Elizabethkingia anophelis
Biochemical properties and substrate specificity of GOB-38 in Elizabethkingia anophelis Open
View article: Delayed psychiatric sequelae following multifocal central nervous system lesions in leptospirosis: A case report
Delayed psychiatric sequelae following multifocal central nervous system lesions in leptospirosis: A case report Open
View article: Pulmonary infection caused by Tropheryma whipplei: a case report and review of the literature
Pulmonary infection caused by Tropheryma whipplei: a case report and review of the literature Open
Background Tropheryma whipplei pneumonia is an infrequent medical condition. The clinical symptoms associated with this disease are nonspecific, often resulting in misdiagnosis or missed diagnosis. Therefore, sharing and summarizing the ex…
View article: An improvised one-step OptiPrep cushion ultracentrifugation method for outer membrane vesicles isolation of Klebsiella pneumoniae
An improvised one-step OptiPrep cushion ultracentrifugation method for outer membrane vesicles isolation of Klebsiella pneumoniae Open
View article: Real-world effectiveness and safety of simnotrelvir/ritonavir for COVID-19: A nationwide, multicenter, prospective, observational cohort study in China
Real-world effectiveness and safety of simnotrelvir/ritonavir for COVID-19: A nationwide, multicenter, prospective, observational cohort study in China Open
In real world, S/R significantly reduced the incidence of COVID-19-related hospitalization, demonstrated favorable safety profiles, and less use of combined medication.
View article: Virulence plasmid with IroBCDN deletion promoted cross-regional transmission of ST11-KL64 carbapenem-resistant hypervirulent Klebsiella pneumoniae in central China
Virulence plasmid with IroBCDN deletion promoted cross-regional transmission of ST11-KL64 carbapenem-resistant hypervirulent Klebsiella pneumoniae in central China Open
View article: Virulence Plasmid with IroBCDN Deletion Promoted Cross-regional Transmission of ST11-KL64 Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae in central China
Virulence Plasmid with IroBCDN Deletion Promoted Cross-regional Transmission of ST11-KL64 Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae in central China Open
Background:Carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKP) caused infections of high mortality and brought a serious impact on public health. This study evaluated the transmissibility of CR-hvKP among different regio…
View article: Temporal shifts in 24 notifiable infectious diseases in China before and during the COVID-19 pandemic
Temporal shifts in 24 notifiable infectious diseases in China before and during the COVID-19 pandemic Open
The coronavirus disease 2019 (COVID-19) pandemic, along with the implementation of public health and social measures (PHSMs), have markedly reshaped infectious disease transmission dynamics. We analysed the impact of PHSMs on 24 notifiable…
View article: Virulence Plasmid with IroBCDN Deletion Promoted Cross-regional Transmission of ST11-KL64 Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae in Jiangxi Province, China
Virulence Plasmid with IroBCDN Deletion Promoted Cross-regional Transmission of ST11-KL64 Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae in Jiangxi Province, China Open
Background Carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKP) caused infections of high mortality and brought a serious impact on public health. This study evaluated the transmissibility of CR-hvKP among different regio…
View article: Leritrelvir for the treatment of mild or moderate COVID-19 without co-administered ritonavir: a multicentre randomised, double-blind, placebo-controlled phase 3 trial
Leritrelvir for the treatment of mild or moderate COVID-19 without co-administered ritonavir: a multicentre randomised, double-blind, placebo-controlled phase 3 trial Open
This study was funded by the National Multidisciplinary Innovation Team Project of Traditional Chinese Medicine, Guangdong Science and Technology Foundation, Guangzhou Science and Technology Planning Project and R&D Program of Guangzhou La…
View article: Analysis of the hypovirulent <i>Klebsiella pneumoniae</i> with the <i>NDM-5</i> gene on IncN plasmids
Analysis of the hypovirulent <i>Klebsiella pneumoniae</i> with the <i>NDM-5</i> gene on IncN plasmids Open
Our study aims to analyze the hypovirulent Klebsiella pneumoniae with the NDM-5 gene on IncN plasmids. This strain was isolated from a patient with a liver abscess, and the ST type was ST147. The characterization, antimicrobial drug resist…
View article: Temporal trends and shifts of 24 notifiable infectious diseases in China before and during the COVID-19 epidemic
Temporal trends and shifts of 24 notifiable infectious diseases in China before and during the COVID-19 epidemic Open
The COVID-19 epidemic and the subsequent implementation of public health and social measures (PHSMs) have markedly reshaped the transmission dynamics of infectious diseases. In this study, we analyzed the impact of PHSMs on 24 notifiable i…
View article: Decoding Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Journey Through Unilateral Cystic Pulmonary Manifestations—A Rare Case and Literature Review
Decoding Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Journey Through Unilateral Cystic Pulmonary Manifestations—A Rare Case and Literature Review Open
We presented an atypical case of a 62-year-old female diagnosed with pulmonary Mucosa-Associated Lymphoid Tissue (p-MALT) lymphoma, uniquely manifesting as a singular cystic lesion in the lung. Diagnostic evaluations, including comprehensi…
View article: Covert dissemination of pLVPK-like virulence plasmid in ST29-K54 Klebsiella pneumoniae: emergence of low virulence phenotype strains
Covert dissemination of pLVPK-like virulence plasmid in ST29-K54 Klebsiella pneumoniae: emergence of low virulence phenotype strains Open
This study aimed to explore the epidemic, clinical characteristics, and molecular and virulence attributes of Klebsiella pneumoniae serotype K54 (K54-Kp). A retrospective study was conducted on 328 strains of Klebsiella pneumoniae screened…
View article: Retrospective comparative analysis of clinical, laboratory, and imaging features of Pneumocystis jirovecii pneumonia among HIV-infected individuals and patients with cancer
Retrospective comparative analysis of clinical, laboratory, and imaging features of Pneumocystis jirovecii pneumonia among HIV-infected individuals and patients with cancer Open
Objective: To retrospectively compare the clinical, laboratory, and imaging features of Pneumocystis jirovecii pneumonia among HIV-infected individuals and patients with cancer in order to provide evidence for early detection, diagnosis, a…
View article: Isolation of Hv-CRKP with co-production of three carbapenemases (blaKPC, blaOXA-181 or OXA-232, and blaNDM-1) and a virulence plasmid: a study from a Chinese tertiary hospital
Isolation of Hv-CRKP with co-production of three carbapenemases (blaKPC, blaOXA-181 or OXA-232, and blaNDM-1) and a virulence plasmid: a study from a Chinese tertiary hospital Open
Background The worldwide dissemination of K. pneumoniae isolates is a significant public health concern, as these organisms possess a unique capacity to acquire genetic elements encoding both resistance and hypervirulence. This study aims …
View article: Four thermostatic steps: A novel CRISPR-Cas12-based system for the rapid at-home detection of respiratory pathogens
Four thermostatic steps: A novel CRISPR-Cas12-based system for the rapid at-home detection of respiratory pathogens Open
View article: Important oncogenic and immunogenic roles of SPP1 and CSF1 in hepatocellular carcinoma
Important oncogenic and immunogenic roles of SPP1 and CSF1 in hepatocellular carcinoma Open
The treatment and prognosis of liver cancer remain the focus of medical research. Studies have shown that SPP1 and CSF1 play important roles in cell proliferation, invasion, and metastasis. Therefore, this study analyzed the oncogenic and …
View article: Case report: Severe pneumonia and pneumomediastinum in a previously robust adolescent caused by Omicron BA.5.2
Case report: Severe pneumonia and pneumomediastinum in a previously robust adolescent caused by Omicron BA.5.2 Open
The manifestation of severe pneumonia is only occasional, and pneumomediastinum is a condition that occurs rarely in Coronavirus disease 2019 (COVID-19) patients, especially in those patients who are infected with the Omicron variant. In a…
View article: Redistribution and Activation of CD16brightCD56dim NK Cell Subset to Fight against Omicron Subvariant BA.2 after COVID-19 Vaccination
Redistribution and Activation of CD16brightCD56dim NK Cell Subset to Fight against Omicron Subvariant BA.2 after COVID-19 Vaccination Open
With the alarming surge in COVID-19 cases globally, vaccination must be prioritised to achieve herd immunity. Immune dysfunction is detected in the majority of patients with COVID-19; however, it remains unclear whether the immune response…
View article: Redistribution and activation of CD16<sup>bright</sup>CD56<sup>dim</sup>NK cell subset to fight against Omicron subvariant BA.2 after COVID-19 vaccination
Redistribution and activation of CD16<sup>bright</sup>CD56<sup>dim</sup>NK cell subset to fight against Omicron subvariant BA.2 after COVID-19 vaccination Open
With the alarming surge in COVID-19 cases globally, vaccination must be prioritised to achieve herd immunity. Immune dysfunction is detected in the majority of patients with COVID-19; however, it remains unclear whether the immune response…
View article: First description of NDM-1 and IMP-1 producing carbapenem-resistant Pseudomonas mendocina
First description of NDM-1 and IMP-1 producing carbapenem-resistant Pseudomonas mendocina Open
Objective: To describe NDM-1 and IMP-1 producing carbapenem-resistant Pseudomonas mendocina . Methods: Antimicrobial susceptibility test was performed on carbapenemase-producing P.mendocina clinical isolate. Whole genome sequencing data we…