Tianyou Luo
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View article: Altered dynamic regional homogeneity and neurovascular coupling in multi-frequency bands in patients with cerebral small vascular disease
Altered dynamic regional homogeneity and neurovascular coupling in multi-frequency bands in patients with cerebral small vascular disease Open
Our findings showed that CSVD patients exhibited impaired dynamic patterns of neuronal synchronization and disrupted neurovascular coupling prior to the onset of dementia, which were associated with cognitive impairment in sub-frequency ba…
View article: Interpretable AI-assisted diagnosis of papillary thyroid cancer cytopathology using graph neural networks and knowledge graphs
Interpretable AI-assisted diagnosis of papillary thyroid cancer cytopathology using graph neural networks and knowledge graphs Open
This study presents an interpretable AI-assisted diagnostic approach for papillary thyroid carcinoma (PTC) cytopathology by combining graph neural networks (GNNs) with knowledge graphs (KGs). Routine cytology smears from 281 PTC cases were…
View article: Diagnostic Challenges and Insights in Optic Nerve Hemangioblastoma using Magnetic Resonance Imaging: A Case Report
Diagnostic Challenges and Insights in Optic Nerve Hemangioblastoma using Magnetic Resonance Imaging: A Case Report Open
Background: Optic nerve hemangioblastoma (ONH) is a rare benign tumor. It can be sporadic or associated with Von-Hippel Lindau (VHL) syndrome. Magnetic resonance imaging (MRI) is the most commonly used diagnostic technique for the tumor. H…
View article: Concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease
Concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease Open
View article: Early Lung Squamous Cell Carcinoma Presenting as Mucoid Impaction of Bronchi: Clinicoradiological Characteristics, Pathological Correlates, and Surgical Prognosis
Early Lung Squamous Cell Carcinoma Presenting as Mucoid Impaction of Bronchi: Clinicoradiological Characteristics, Pathological Correlates, and Surgical Prognosis Open
View article: Molecular Dynamics Study of Void-Induced Defect Evolution and Strength Reduction in high-entropy alloy
Molecular Dynamics Study of Void-Induced Defect Evolution and Strength Reduction in high-entropy alloy Open
View article: Radiomics based on diffusion tensor imaging and 3D T1-weighted MRI for essential tremor diagnosis
Radiomics based on diffusion tensor imaging and 3D T1-weighted MRI for essential tremor diagnosis Open
Background Due to the absence of biomarkers, the misdiagnosis of essential tremor (ET) with other tremor diseases and enhanced physiologic tremor is very common in practice. Combined radiomics based on diffusion tensor imaging (DTI) and th…
View article: Multi-echo three-dimensional (3D) Dixon sequence combined with disodium gadolinium for risk stratification of advanced fibrosis in metabolic dysfunction-associated steatotic liver disease
Multi-echo three-dimensional (3D) Dixon sequence combined with disodium gadolinium for risk stratification of advanced fibrosis in metabolic dysfunction-associated steatotic liver disease Open
Magnetic RE had high effectiveness for distinguishing between liver-fibrosis risk levels. The combination of the Q-Dixon sequence and Gd-EOB-DTPA has the potential of one-stop evaluation of MASLD.
View article: Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease
Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease Open
Introduction Prior MRI studies have shown that patients with subcortical ischemic vascular disease (SIVD) exhibited white matter damage, gray matter atrophy and memory impairment, but the specific characteristics and interrelationships of …
View article: Solitary lung adenocarcinoma: follow-up CT, pathological-molecular characteristics, and surgical prognosis for different morphological classifications
Solitary lung adenocarcinoma: follow-up CT, pathological-molecular characteristics, and surgical prognosis for different morphological classifications Open
View article: Association between <i>de novo</i> variants of nuclear-encoded mitochondrial-related genes and undiagnosed developmental disorder and autism
Association between <i>de novo</i> variants of nuclear-encoded mitochondrial-related genes and undiagnosed developmental disorder and autism Open
Summary Background Evidence suggests that mitochondrial abnormalities increase the risk of two neurodevelopmental disorders: undiagnosed developmental disorder (UDD) and autism spectrum disorder (ASD). However, which nuclear-encoded mitoch…
View article: The pivotal role of the X-chromosome in the genetic architecture of the human brain
The pivotal role of the X-chromosome in the genetic architecture of the human brain Open
Genes on the X-chromosome are extensively expressed in the human brain. However, little is known for the X-chromosome’s impact on the brain anatomy, microstructure, and functional network. We examined 1,045 complex brain imaging traits fro…
View article: Using histogram analysis of the intrinsic brain activity mapping to identify essential tremor
Using histogram analysis of the intrinsic brain activity mapping to identify essential tremor Open
Background Essential tremor (ET) is one of the most common movement disorders. Histogram analysis based on brain intrinsic activity imaging is a promising way to identify ET patients from healthy controls (HCs) and further explore the spon…
View article: Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images
Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images Open
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance …
View article: Comparison of Three Algorithms for Predicting Infarct Volume in Patients with Acute Ischemic Stroke by CT Perfusion Software: Bayesian, CSVD, and OSVD
Comparison of Three Algorithms for Predicting Infarct Volume in Patients with Acute Ischemic Stroke by CT Perfusion Software: Bayesian, CSVD, and OSVD Open
This study aimed to compare the performance of the Bayesian probabilistic method, circular Singular Value Decomposition (cSVD), and oscillation index Singular Value Decomposition (oSVD) algorithms in Olea Sphere for predicting infarct volu…
View article: Cell composition inference and identification of layer-specific spatial transcriptional profiles with POLARIS
Cell composition inference and identification of layer-specific spatial transcriptional profiles with POLARIS Open
Spatial transcriptomics (ST) technology, providing spatially resolved transcriptional profiles, facilitates advanced understanding of key biological processes related to health and disease. Sequencing-based ST technologies provide whole-tr…
View article: The Effect of Magnetic Resonance Imaging Based Radiomics Models in Discriminating stage I–II and III–IVa Nasopharyngeal Carcinoma
The Effect of Magnetic Resonance Imaging Based Radiomics Models in Discriminating stage I–II and III–IVa Nasopharyngeal Carcinoma Open
Background: Nasopharyngeal carcinoma (NPC) is a common tumor in China. Accurate stages of NPC are crucial for treatment. We therefore aim to develop radiomics models for discriminating early-stage (I–II) and advanced-stage (III–IVa) NPC ba…
View article: The different damage patterns of short-, middle- and long-range connections between patients with relapse-remitting multiple sclerosis and neuromyelitis optica spectrum disorder
The different damage patterns of short-, middle- and long-range connections between patients with relapse-remitting multiple sclerosis and neuromyelitis optica spectrum disorder Open
Objective To investigate the differences in short-, middle- and long-range connections between patients with relapse-remitting multiple sclerosis (RRMS) and neuromyelitis optica spectrum disorder (NMOSD), and their correlation with brain t…
View article: Diffusion kurtosis imaging and diffusion tensor imaging parameters applied to white matter and gray matter of patients with anti-N-methyl-D-aspartate receptor encephalitis
Diffusion kurtosis imaging and diffusion tensor imaging parameters applied to white matter and gray matter of patients with anti-N-methyl-D-aspartate receptor encephalitis Open
Objectives To compare parameters of diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) to evaluate which can better describe the microstructural changes of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis patients a…
View article: Genetic influences on the shape of brain ventricular and subcortical structures
Genetic influences on the shape of brain ventricular and subcortical structures Open
Brain ventricular and subcortical structures are heritable both in size and shape. Genetic influences on brain region size have been studied using conventional volumetric measures, but little is known about the genetic basis of ventricular…
View article: Using combined CT-clinical radiomics models to identify epidermal growth factor receptor mutation subtypes in lung adenocarcinoma
Using combined CT-clinical radiomics models to identify epidermal growth factor receptor mutation subtypes in lung adenocarcinoma Open
Background To investigate the value of computed tomography (CT)-based radiomics signatures in combination with clinical and CT morphological features to identify epidermal growth factor receptor (EGFR)-mutation subtypes in lung adenocarcin…
View article: A comprehensive comparison on cell-type composition inference for spatial transcriptomics data
A comprehensive comparison on cell-type composition inference for spatial transcriptomics data Open
Spatial transcriptomics (ST) technologies allow researchers to examine transcriptional profiles along with maintained positional information. Such spatially resolved transcriptional characterization of intact tissue samples provides an int…
View article: Combined model of radiomics, clinical, and imaging features for differentiating focal pneumonia-like lung cancer from pulmonary inflammatory lesions: an exploratory study
Combined model of radiomics, clinical, and imaging features for differentiating focal pneumonia-like lung cancer from pulmonary inflammatory lesions: an exploratory study Open
Background Only few studies have focused on differentiating focal pneumonia-like lung cancer (F-PLC) from focal pulmonary inflammatory lesion (F-PIL). This exploratory study aimed to evaluate the clinical value of a combined model incorpor…
View article: Combined Intrinsic Local Functional Connectivity With Multivariate Pattern Analysis to Identify Depressed Essential Tremor
Combined Intrinsic Local Functional Connectivity With Multivariate Pattern Analysis to Identify Depressed Essential Tremor Open
Background Although depression is one of the most common neuropsychiatric symptoms in essential tremor (ET), the diagnosis biomarker and intrinsic brain activity remain unclear. We aimed to combine multivariate pattern analysis (MVPA) with…
View article: Common variants contribute to intrinsic human brain functional networks
Common variants contribute to intrinsic human brain functional networks Open
View article: DADP: Dynamic abnormality detection and progression for longitudinal knee magnetic resonance images from the Osteoarthritis Initiative
DADP: Dynamic abnormality detection and progression for longitudinal knee magnetic resonance images from the Osteoarthritis Initiative Open
Osteoarthritis (OA) is the most common disabling joint disease. Magnetic resonance (MR) imaging has been commonly used to assess knee joint degeneration due to its distinct advantage in detecting morphologic cartilage changes. Although sev…
View article: Heart-brain connections: phenotypic and genetic insights from 40,000 cardiac and brain magnetic resonance images
Heart-brain connections: phenotypic and genetic insights from 40,000 cardiac and brain magnetic resonance images Open
Cardiovascular health interacts with cognitive and psychological health in complex ways. Yet, little is known about the phenotypic and genetic links of heart-brain systems. Using cardiac and brain magnetic resonance imaging (CMR and brain …
View article: Genetic influences on the intrinsic and extrinsic functional organizations of the cerebral cortex
Genetic influences on the intrinsic and extrinsic functional organizations of the cerebral cortex Open
The human cerebral cortex is a vital component of brain function, but the genetic influences on cortical functional organization remain poorly understood. In this study, we used a parcellation-based approach to process resting-state and ta…
View article: Common genetic variation influencing human white matter microstructure
Common genetic variation influencing human white matter microstructure Open
Connecting the dots on white matter The white matter of the brain, which is composed of axonal tracts connecting different brain regions, plays key roles in both normal brain function and a variety of neurological disorders. Zhao et al. co…
View article: Development and Validation of a Combined Model for Preoperative Prediction of Lymph Node Metastasis in Peripheral Lung Adenocarcinoma
Development and Validation of a Combined Model for Preoperative Prediction of Lymph Node Metastasis in Peripheral Lung Adenocarcinoma Open
Background Based on the “seed and soil” theory proposed by previous studies, we aimed to develop and validate a combined model of machine learning for predicting lymph node metastasis (LNM) in patients with peripheral lung adenocarcinoma (…