Tonghui Ma
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View article: Illuminating the <i>FGFR</i> fusion landscape in Chinese patients: unveiling novel molecular insights and clinical implications
Illuminating the <i>FGFR</i> fusion landscape in Chinese patients: unveiling novel molecular insights and clinical implications Open
Background Despite the increasing approval and ongoing clinical trials of FGFR-targeted therapies, accurately detecting FGFR fusions remains a challenge due to limited research, low incidence rates, complex fusion partner distribution, and…
View article: HPGD induces ferroptosis and autophagy to suppress esophageal squamous cell carcinoma through the LXA4–ERK1/2–U2AF2–TFRC axis
HPGD induces ferroptosis and autophagy to suppress esophageal squamous cell carcinoma through the LXA4–ERK1/2–U2AF2–TFRC axis Open
Background Although 15-hydroxyprostaglandin dehydrogenase (HPGD) is known to regulate the metabolism of prostaglandins and lipoxin A4, and its dysregulation has been implicated in various cancers, its role in esophageal squamous cell carci…
View article: Development and preliminary verification of the scale of care needs of family caregivers of patients with bladder cancer undergoing urostomy
Development and preliminary verification of the scale of care needs of family caregivers of patients with bladder cancer undergoing urostomy Open
As the main undertakers of home care for urostomy patients after discharge, family caregivers play an important role in patients' postoperative recovery. Family caregivers of patients with urostomy may be under greater pressure than patien…
View article: Hypoxia-induced tumor cell-intrinsic PLAU activation drives immunotherapy resistance in collagenic lung adenocarcinoma
Hypoxia-induced tumor cell-intrinsic PLAU activation drives immunotherapy resistance in collagenic lung adenocarcinoma Open
Activation of the PLAU-PLAUR pathway is essential for the progression of hypoxia-associated LUAD exhibiting a collagenous phenotype. Blocking the pathway provides a new research perspective for the development of immunotherapy for LUAD.
View article: Potential of Urinary Mutation and Methylation Biomarkers in Selecting Candidates for Repeat Transurethral Resection of Bladder Tumor in Non–muscle-invasive Bladder Cancer: A Prospective Multicenter Study
Potential of Urinary Mutation and Methylation Biomarkers in Selecting Candidates for Repeat Transurethral Resection of Bladder Tumor in Non–muscle-invasive Bladder Cancer: A Prospective Multicenter Study Open
View article: Superiority of targeted RNA sequencing for fusion detection and subtype diagnosis in Chinese sarcoma patients: a multicenter study
Superiority of targeted RNA sequencing for fusion detection and subtype diagnosis in Chinese sarcoma patients: a multicenter study Open
Sarcomas are rare, heterogeneous mesenchymal malignancies with notably high misdiagnosis rates. Despite sarcoma patients in China representing about one-quarter of the global disease burden, large-scale NGS-based diagnostic studies remain …
View article: Silkworm pupae extract attenuates diabetic kidney disease through inhibiting apoptosis
Silkworm pupae extract attenuates diabetic kidney disease through inhibiting apoptosis Open
View article: Non-canonical small noncoding RNAs in the plasma extracellular vesicles as novel biomarkers in gastric cancer
Non-canonical small noncoding RNAs in the plasma extracellular vesicles as novel biomarkers in gastric cancer Open
Identifying robust diagnostic biomarkers for gastric cancer (GC) remains a significant challenge. Emerging studies highlight extracellular vesicle (EV)-derived RNAs in cancer biology, but the diagnostic potential of circulating EV-derived …
View article: Hetrombopag: A promising thrombopoietin receptor agonist for the treatment of primary and secondary immune thrombocytopenia
Hetrombopag: A promising thrombopoietin receptor agonist for the treatment of primary and secondary immune thrombocytopenia Open
Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by a platelet count below 100 × 10 9 /L. This review aims to comprehensively summarize the current evidence on the use of thrombopoietin receptor agonists (TPO‐RAs),…
View article: UBE2Q1 Impairs Antigen Presentation and Degrades HDAC1 in AML
UBE2Q1 Impairs Antigen Presentation and Degrades HDAC1 in AML Open
View article: IL1A: a novel prognostic biomarker and potential therapeutic target for renal clear cell carcinoma
IL1A: a novel prognostic biomarker and potential therapeutic target for renal clear cell carcinoma Open
In conclusion, our study demonstrates the potential role of IL 1A in the prognosis of RCC and establishes a theoretical foundation for subsequent in vivo and clinical investigations.
View article: Scutellarin from Breviscapine Injection Prevents Lethal Enterovirus 71 Infection by Inhibiting Neuroinflammation and Oxidative Stress in Newborn Mice
Scutellarin from Breviscapine Injection Prevents Lethal Enterovirus 71 Infection by Inhibiting Neuroinflammation and Oxidative Stress in Newborn Mice Open
View article: Rhoifolin prevents herpes simplex virus encephalitis by modulating SESN2 to regulate the Keap1/Nrf2 and AMPK/Nox pathways to inhibit neuro-oxidative damage in mice
Rhoifolin prevents herpes simplex virus encephalitis by modulating SESN2 to regulate the Keap1/Nrf2 and AMPK/Nox pathways to inhibit neuro-oxidative damage in mice Open
View article: 1427 Precision Immunomics<sup>TM</sup>: identification of hundreds of novel cancer antigens using a sensitive immunopeptidomics-led platform
1427 Precision Immunomics<sup>TM</sup>: identification of hundreds of novel cancer antigens using a sensitive immunopeptidomics-led platform Open
View article: Clinical relevance and druggability of sole reciprocal kinase fusions: A large‐scale study
Clinical relevance and druggability of sole reciprocal kinase fusions: A large‐scale study Open
Background Building on our prior work that RNA alternative splicing modulates the druggability of kinase fusions, this study probes the clinical significance of sole reciprocal fusions. These rare genomic arrangements, despite lacking kina…
View article: Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects
Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects Open
The NLRP3 inflammasome plays a pivotal role in various chronic inflammation-driven human diseases. However, no drugs specifically targeting NLRP3 inflammasome have been approved by the Food and Drug Administration (FDA) of the United State…
View article: Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy
Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy Open
Background Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or pro…
View article: Sequential gene expression analysis of myelodysplastic syndrome transformation identifies HOXB3 and HOXB7 as the novel targets for mesenchymal cells in disease
Sequential gene expression analysis of myelodysplastic syndrome transformation identifies HOXB3 and HOXB7 as the novel targets for mesenchymal cells in disease Open
View article: Aortic root reinforcement combined with vascular rafts eversion and built-in procedure for Acute Type A Aortic dissection surgery
Aortic root reinforcement combined with vascular rafts eversion and built-in procedure for Acute Type A Aortic dissection surgery Open
Background Acute type A aortic dissection (ATAAD) is a life-threatening disease with high mortality. Surgery remains the gold standard for the treatment of ATAAD. However, ATAAD surgery, especially the aortic root reinforcement technique, …
View article: A urinary assay for mutation and methylation biomarkers in the diagnosis and recurrence prediction of non-muscle invasive bladder cancer patients
A urinary assay for mutation and methylation biomarkers in the diagnosis and recurrence prediction of non-muscle invasive bladder cancer patients Open
View article: Prevalence and spectrum of cancer predisposition germline mutations in young patients with the common late‐onset cancers
Prevalence and spectrum of cancer predisposition germline mutations in young patients with the common late‐onset cancers Open
Background Pathogenic germline variants (PGVs) can play a vital role in the oncogenesis process in carriers. Previous studies have recognized that PGVs contribute to early onset of tumorigenesis in certain cancer types, for example, colore…
View article: Novel insights into molecular patterns of <i>ROS1</i> fusions in a large Chinese <scp>NSCLC</scp> cohort: a multicenter study
Novel insights into molecular patterns of <i>ROS1</i> fusions in a large Chinese <span>NSCLC</span> cohort: a multicenter study Open
ROS proto‐oncogene 1, receptor tyrosine kinase ( ROS1 ) rearrangements are a crucial therapeutic target in non‐small cell lung cancer (NSCLC). However, there is limited comprehensive analysis of the molecular patterns of ROS1 fusions. This…
View article: Case report: Complete response of an anaplastic thyroid carcinoma patient with NRAS Q61R/BRAF D594N mutations to the triplet of dabrafenib, trametinib and PD-1 antibody
Case report: Complete response of an anaplastic thyroid carcinoma patient with NRAS Q61R/BRAF D594N mutations to the triplet of dabrafenib, trametinib and PD-1 antibody Open
Anaplastic thyroid carcinoma, BRAF non-V600, NRAS , combination immunotherapy and targeted therapy, case report. Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid cancer with a mortality rate near 100%. BRAF V600 and NRAS mutati…
View article: Molecular and clinical features of papillary thyroid cancer in adult patients with a non-classical phenotype
Molecular and clinical features of papillary thyroid cancer in adult patients with a non-classical phenotype Open
Purpose Genotyping is fundamental in papillary thyroid cancer (PTC) and helps to enhance diagnosis and prognosis and determine appropriate treatments. The phenotype-genotype association in PTC was previously studied, with BRAF V600E charac…
View article: Pathogenic genomic alterations in Chinese pancreatic cancer patients and their therapeutical implications
Pathogenic genomic alterations in Chinese pancreatic cancer patients and their therapeutical implications Open
Background Approximately 90% of pancreatic ductal adenocarcinoma (PDAC) cases are driven by the untargetable non‐G12C KRAS mutations, and only a small subset of patients are eligible for FDA‐approved precision therapies. The practice of pr…
View article: AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Na<sub>v</sub>1.6‐Mediated Astrocyte Autophagy
AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Na<sub>v</sub>1.6‐Mediated Astrocyte Autophagy Open
The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects of AQP4 associated with SAE and reveal its underlying mechanism cau…
View article: Dopamine promotes<i>Klebsiella quasivariicola</i>proliferation and inflammatory response in the presence of macrophages
Dopamine promotes<i>Klebsiella quasivariicola</i>proliferation and inflammatory response in the presence of macrophages Open
Klebsiella quasivariicola was a novel strain of Klebsiella species and had potential pathogenicity. Our previously studies showed dopamine, one of the most commonly used rescue drugs for critically ill patients, had clear effects on the gr…
View article: Driver and targetable alterations in Chinese patients with small bowel carcinoma
Driver and targetable alterations in Chinese patients with small bowel carcinoma Open
View article: Profiling of the genetic features of Chinese patients with gastric cancer with HRD germline mutations in a large-scale retrospective study
Profiling of the genetic features of Chinese patients with gastric cancer with HRD germline mutations in a large-scale retrospective study Open
Background Approximately 10% of gastric cancers (GCs) are associated with strong familial clustering and can be attributed to genetic predisposition. Homologous recombination deficiency (HRD) leads to genomic instability and accumulation o…
View article: Association of <i>KMT2C/D</i> loss‐of‐function variants with response to immune checkpoint blockades in colorectal cancer
Association of <i>KMT2C/D</i> loss‐of‐function variants with response to immune checkpoint blockades in colorectal cancer Open
Immune checkpoint inhibitors (ICIs) have become important treatment strategies, yet responses vary among patients and predictive biomarkers are urgently needed. Mutations in KMT2C and KMT2D lead to increased levels of genomic instability. …