Ting‐Yu Lai
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View article: Myeloid ZNRF1 suppresses autoimmune demyelination and neuroinflammation by regulating MHC-II-mediated T cell activation
Myeloid ZNRF1 suppresses autoimmune demyelination and neuroinflammation by regulating MHC-II-mediated T cell activation Open
Multiple sclerosis (MS) is an autoimmune and neuroinflammation disease characterized by axonal damage, inflammatory demyelination, and neurodegeneration. However, the precise mechanisms underlying MS pathogenesis remain largely unclear. He…
View article: Differential effects of calcineurin inhibitors on plasma cells: Potential therapy for antibody- mediated rejection
Differential effects of calcineurin inhibitors on plasma cells: Potential therapy for antibody- mediated rejection Open
Calcineurin inhibitors, including cyclosporine and tacrolimus, are widely used to prevent postoperative rejection after solid organ transplantation and have successfully prolonged the survival of allografts since their introduction. The us…
View article: Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration
Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration Open
View article: Unraveling the impact of cancer-associated fibroblasts on hypovascular pancreatic neuroendocrine tumors
Unraveling the impact of cancer-associated fibroblasts on hypovascular pancreatic neuroendocrine tumors Open
Background Pancreatic neuroendocrine tumors (PNETs) with low microvessel density and fibrosis often exhibit clinical aggressiveness. Given the contribution of cancer-associated fibroblasts (CAFs) to the hypovascular fibrotic stroma in panc…
View article: The Way to Malignant Transformation: Can Epigenetic Alterations Be Used to Diagnose Early-Stage Head and Neck Cancer?
The Way to Malignant Transformation: Can Epigenetic Alterations Be Used to Diagnose Early-Stage Head and Neck Cancer? Open
Identifying and treating tumors early is the key to secondary prevention in cancer control. At present, prevention of oral cancer is still challenging because the molecular drivers responsible for malignant transformation of the 11 clinica…
View article: The Src–ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage
The Src–ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage Open
Type I interferons are important antiviral cytokines, but prolonged interferon production is detrimental to the host. The TLR3-driven immune response is crucial for mammalian antiviral immunity, and its intracellular localization determine…
View article: Different methods of detaching adherent cells and their effects on the cell surface expression of Fas receptor and Fas ligand
Different methods of detaching adherent cells and their effects on the cell surface expression of Fas receptor and Fas ligand Open
View article: Identification of Prognostic Biomarkers Originating From the Tumor Stroma of Betel Quid-Associated Oral Cancer Tissues
Identification of Prognostic Biomarkers Originating From the Tumor Stroma of Betel Quid-Associated Oral Cancer Tissues Open
Background Partial epithelial-mesenchymal transition (p-EMT) is a distinct clinicopathological feature prevalent in oral cavity tumors of The Cancer Genome Atlas. Located at the invasion front, p-EMT cells require additional support from t…
View article: Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation Open
View article: ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination to Control Receptor Lysosomal Trafficking and Degradation
ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination to Control Receptor Lysosomal Trafficking and Degradation Open
Activation of the epidermal growth factor receptor (EGFR) is crucial for development, tissue homeostasis, and immunity. Dysregulation of EGFR signaling is associated with numerous diseases. EGFR ubiquitination and endosomal trafficking are…
View article: The Role of S100A9 in the Interaction Between Pancreatic Ductal Adenocarcinoma Cells and Stromal Cells
The Role of S100A9 in the Interaction Between Pancreatic Ductal Adenocarcinoma Cells and Stromal Cells Open
Background: A major feature of the microenvironment in pancreatic ductal adenocarcinoma (PDAC) is the significant amount of extracellular matrix produced by pancreatic stellate cells (PSCs), which have been reported to enhance the invasiven…
View article: The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation
The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation Open
View article: The influence of a caveolin-1 mutant on the function of P-glycoprotein
The influence of a caveolin-1 mutant on the function of P-glycoprotein Open
The genetic heterogeneity in cancer cells has an increased chance in the acquisition of new mutant such as drug-resistant phenotype in cancer cells. The phenotype of drug resistance in cancer cells could be evaluated by the number or funct…