Tony Wu
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View article: Respiratory Arousal Threshold in Patients with Epilepsy and Obstructive Sleep Apnea
Respiratory Arousal Threshold in Patients with Epilepsy and Obstructive Sleep Apnea Open
Our study provides insights into the presence of a low rAT in PWE+OSA, with no significant difference in its ratio compared to OSA controls. However, since rAT was estimated using a predictive model rather than direct measurement, this lim…
View article: Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila
Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila Open
This study suggests that 16-hour water deprivation or 24-hour food deprivation does not significantly alter dopamine production and neural activity in MB-innervating DANs. These findings offer insights into the independence of baseline dop…
View article: Dynamics of two distinct memory interactions during water seeking in <i>Drosophila</i>
Dynamics of two distinct memory interactions during water seeking in <i>Drosophila</i> Open
Forming and forgetting memories shape our self-awareness and help us face future challenges. Therefore, understanding how memories are formed and how different memories interact in the brain is important. Previous studies have shown that t…
View article: Supp Figs (Fig S1-4) and Tables (Tables S1-4) from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Supp Figs (Fig S1-4) and Tables (Tables S1-4) from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
Cross-validated test; DELFI score distribution; Annual transitions.
View article: Supplementary Tables S5 and S6 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Supplementary Tables S5 and S6 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
Whole genome cfDNA analyses. Clinical and demographic characteristics of individuals analyzed.
View article: Table 1 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Table 1 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
Participant demographics and clinical characteristics.
View article: Figure 3 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Figure 3 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
High-dimensional fragmentation features reflect lung cancer biology and are incorporated in the machine learning classifier. A, Heatmap representation of the deviation of cfDNA fragmentation features across the genome for the classi…
View article: Supplementary Methods from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Supplementary Methods from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
Additional detailed methods
View article: Figure 5 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Figure 5 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
Population health benefits of a blood-based test in lung cancer screening. A, Care pathway reflecting the recommended standard of care for lung cancer screening with LDCT that is received by 6%–10% of eligible individuals annually, …
View article: Figure 4 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Figure 4 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
Performance of blood-based lung cancer screening test. A, Sensitivity and specificity of the test in the clinical validation set (N = 382) overall and by clinical subgroup. Point estimates are reported with 95% Wilson confide…
View article: Data from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Data from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
Lung cancer screening via annual low-dose computed tomography has poor adoption. We conducted a prospective case–control study among 958 individuals eligible for lung cancer screening to develop a blood-based lung cancer detection test tha…
View article: Figure 2 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Figure 2 from Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
Genome-wide fragmentation profiles are altered in patients with cancer and reflect underlying chromatin structure. A, The fragmentation profile (ratio of short to long cfDNA fragments in 5 Mb bins) across the genome was evaluated in…
View article: Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsy
Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsy Open
The amygdaloid complex consists of multiple nuclei and is a key node in controlling temporal lobe epilepsy (TLE) in both human and animal model studies. However, the specific nucleus in the amygdaloid complex and the neural circuitry gover…
View article: Cancer treatment monitoring using cell-free DNA fragmentomes
Cancer treatment monitoring using cell-free DNA fragmentomes Open
View article: The Neural Correlations of Olfactory Associative Reward Memories in Drosophila
The Neural Correlations of Olfactory Associative Reward Memories in Drosophila Open
Advancing treatment to resolve human cognitive disorders requires a comprehensive understanding of the molecular signaling pathways underlying learning and memory. While most organ systems evolved to maintain homeostasis, the brain develop…
View article: Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection Open
Lung cancer screening via annual low-dose computed tomography has poor adoption. We conducted a prospective case–control study among 958 individuals eligible for lung cancer screening to develop a blood-based lung cancer detection test tha…
View article: Targeted Thrombolysis with Magnetic Nanotherapeutics: A Translational Assessment
Targeted Thrombolysis with Magnetic Nanotherapeutics: A Translational Assessment Open
Plasminogen activators, such as recombinant tissue-type plasminogen activators (rtPAs), while effective in treating thromboembolic diseases, often induce hemorrhagic complications due to non-specific enzyme activities in the systemic circu…
View article: Probiotic <i>Lactobacillus</i> spp. improves <i>Drosophila</i> memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons
Probiotic <i>Lactobacillus</i> spp. improves <i>Drosophila</i> memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons Open
Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying…
View article: Therapeutic drug monitoring of perampanel: Clinical utility and impact of co-medication on pharmacokinetic variability
Therapeutic drug monitoring of perampanel: Clinical utility and impact of co-medication on pharmacokinetic variability Open
PER concentration exhibited a linear regression relationship with PER dose, and the plasma concentration of the drug was highly susceptible to the drug's interactions with enzyme-inducing ASMs. TDM with clear indication could help determin…
View article: Thermosensation and Temperature Preference: From Molecules to Neuronal Circuits in Drosophila
Thermosensation and Temperature Preference: From Molecules to Neuronal Circuits in Drosophila Open
Temperature has a significant effect on all physiological processes of animals. Suitable temperatures promote responsiveness, movement, metabolism, growth, and reproduction in animals, whereas extreme temperatures can cause injury or even …
View article: Clinical impact of therapeutic drug monitoring for newer anti-seizure medications in patients with epilepsy: A real-world observation study
Clinical impact of therapeutic drug monitoring for newer anti-seizure medications in patients with epilepsy: A real-world observation study Open
These findings suggest that appropriate utilization of TDM for newer ASMs provides clinical benefits in adjunct to complement clinical decision making in the management of epilepsy patients in a real-world clinical setting.
View article: Independent insulin signaling modulators govern hot avoidance under different feeding states
Independent insulin signaling modulators govern hot avoidance under different feeding states Open
Thermosensation is critical for the survival of animals. However, mechanisms through which nutritional status modulates thermosensation remain unclear. Herein, we showed that hungry Drosophila exhibit a strong hot avoidance behavior (HAB) …
View article: PROSPECTIVE EVALUATION OF CELL-FREE DNA FRAGMENTATION PROFILES FOR LUNG CANCER DETECTION
PROSPECTIVE EVALUATION OF CELL-FREE DNA FRAGMENTATION PROFILES FOR LUNG CANCER DETECTION Open
View article: Juvenile Myoclonic Epilepsy: Seizure and Social Outcomes in Taiwan
Juvenile Myoclonic Epilepsy: Seizure and Social Outcomes in Taiwan Open
Patients with juvenile myoclonic epilepsy (JME) may not achieve seizure freedom despite optimal treatment with antiseizure medications (ASMs). The aim of this study was to investigate the clinical and social features of patients with JME, …
View article: Interlayers and associated systems, devices, and methods
Interlayers and associated systems, devices, and methods Open
Embodiments related to interlayers (e.g., interlayers comprising a transition metal oxide, a transition metal oxynitride, and/or a transition metal nitride) and associated systems, devices (e.g., photovoltaic devices), and methods are disc…
View article: 2234 Perampanel for the treatment of paediatric patients in clinical practice by age category
2234 Perampanel for the treatment of paediatric patients in clinical practice by age category Open
Objectives To assess perampanel (PER) in everyday clinical practice in paediatric patients. Methods Paediatric patients treated with PER were identified from a pooled analysis of 44 global studies. Retention was assessed after 3, 6 and 12 …
View article: Reduced Sleep Quality Is Related to Poor Quality of Life in Patients with Juvenile Myoclonic Epilepsy, a Case-Control Study
Reduced Sleep Quality Is Related to Poor Quality of Life in Patients with Juvenile Myoclonic Epilepsy, a Case-Control Study Open
Juvenile myoclonic epilepsy (JME) is a primary generalized epilepsy which is closely related to the sleep-wake cycle. This study aimed to investigate whether sleep disturbance is more common among patients with JME and the impact this may …
View article: Drosophila Model for Studying Gut Microbiota in Behaviors and Neurodegenerative Diseases
Drosophila Model for Studying Gut Microbiota in Behaviors and Neurodegenerative Diseases Open
Mounting evidence indicates that the gut microbiota is linked to several physiological processes and disease development in mammals; however, the underlying mechanisms remained unexplored mostly due to the complexity of the mammalian gut m…
View article: Serotonin Signals Modulate Mushroom Body Output Neurons for Sustaining Water-Reward Long-Term Memory in Drosophila
Serotonin Signals Modulate Mushroom Body Output Neurons for Sustaining Water-Reward Long-Term Memory in Drosophila Open
Memory consolidation is a time-dependent process through which an unstable learned experience is transformed into a stable long-term memory; however, the circuit and molecular mechanisms underlying this process are poorly understood. The D…
View article: Targeting AML dependency on VCP-mediated DNA repair through a selective second-generation small molecule inhibitor
Targeting AML dependency on VCP-mediated DNA repair through a selective second-generation small molecule inhibitor Open
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