Tie‐Ning Zhang
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View article: Cellular and molecular mechanisms underlying cardiovascular aging
Cellular and molecular mechanisms underlying cardiovascular aging Open
Aging is a primary risk factor driving the increased prevalence of cardiovascular diseases, significantly contributing to global mortality and healthcare burdens. Aging-related alterations, including genomic instability, telomere shortenin…
View article: Role of oxidative stress in sepsis: Mechanisms, pathways, and therapeutic strategies
Role of oxidative stress in sepsis: Mechanisms, pathways, and therapeutic strategies Open
View article: Molecular mechanisms and functions of protein acetylation in sepsis and sepsis-associated organ dysfunction
Molecular mechanisms and functions of protein acetylation in sepsis and sepsis-associated organ dysfunction Open
Sepsis, a life-threatening condition characterized by organ dysfunction due to dysregulated host response to infection, remains a global health challenge with high morbidity, mortality, and long-term sequelae. The development of sepsis-ass…
View article: Endothelial CLEC5A drives barrier dysfunction and vascular leakage responsible for lung injury in bacterial pneumonia and sepsis
Endothelial CLEC5A drives barrier dysfunction and vascular leakage responsible for lung injury in bacterial pneumonia and sepsis Open
Endothelial barrier dysfunction and the resulting vascular injury are responsible for multiorgan failure in sepsis. Myeloid C-type lectin domain family 5 member A (CLEC5A) is a pattern recognition receptor involved in host defense against …
View article: Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases Open
Histone deacetylase(HDAC) is Zn 2+ ‐dependent histone deacetylases that regulate the key signalling pathways involved in gene transcription. 11 isoforms have been identified. Recent in vitro and in vivo studies have shown that HDACs are in…
View article: Correction: HNF4A mitigates sepsis-associated lung injury by upregulating NCOA2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype
Correction: HNF4A mitigates sepsis-associated lung injury by upregulating NCOA2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype Open
View article: HNF4A mitigates sepsis-associated lung injury by upregulating NCOA2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype
HNF4A mitigates sepsis-associated lung injury by upregulating NCOA2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype Open
Sepsis can trigger systemic inflammation and lead to detrimental effects on several organs, with particular emphasis on the lungs. In sepsis-associated lung injury, macrophages assume a pivotal role, as their overactivation could facilitat…
View article: Role of histone deacetylases and their inhibitors in neurological diseases
Role of histone deacetylases and their inhibitors in neurological diseases Open
Histone deacetylases (HDACs) are zinc-dependent deacetylases that remove acetyl groups from lysine residues of histones or form protein complexes with other proteins for transcriptional repression, changing chromatin structure tightness, a…
View article: Histone deacetylases and their inhibitors in inflammatory diseases
Histone deacetylases and their inhibitors in inflammatory diseases Open
Despite considerable research efforts, inflammatory diseases remain a heavy burden on human health, causing significant economic losses annually. Histone deacetylases (HDACs) play a significant role in regulating inflammation (via histone …
View article: [Recent research on pyroptosis in sepsis-induced myocardial depression].
[Recent research on pyroptosis in sepsis-induced myocardial depression]. Open
Sepsis-induced myocardial depression (SIMD), a common complication of sepsis, is one of the main causes of death in patients with sepsis. The pathogenesis of SIMD is complicated, and the process of SIMD remains incompletely understood, wit…
View article: Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases
Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases Open
Inflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden …
View article: KCTD15 acts as an anti-tumor factor in colorectal cancer cells downstream of the demethylase FTO and the m6A reader YTHDF2
KCTD15 acts as an anti-tumor factor in colorectal cancer cells downstream of the demethylase FTO and the m6A reader YTHDF2 Open
View article: Integration of transcriptomic, proteomic, and metabolomic data to identify lncRNA rPvt1 associations in lipopolysaccharide-treated H9C2 cardiomyocytes
Integration of transcriptomic, proteomic, and metabolomic data to identify lncRNA rPvt1 associations in lipopolysaccharide-treated H9C2 cardiomyocytes Open
Background: Recent evidence has shown that the long non-coding RNA (lncRNA) rPvt1 is elevated in septic myocardial tissues and that its knockdown attenuates sepsis-induced myocardial injury. However, the mechanism underlying the role of rP…
View article: Risk Factors for Mortality and Functional Status Among Survivors of Pediatric Acute Respiratory Distress Syndrome
Risk Factors for Mortality and Functional Status Among Survivors of Pediatric Acute Respiratory Distress Syndrome Open
Purpose Although the mortality rate of pediatric acute respiratory distress syndrome (PARDS) continues to decrease, the increased incidence of clinical sequelae in survivors has become a focus of clinical practice. This study aimed to dete…
View article: Risk Factors for Mortality and Functional Status Among Survivors of Pediatric Acute Respiratory Distress Syndrome
Risk Factors for Mortality and Functional Status Among Survivors of Pediatric Acute Respiratory Distress Syndrome Open
Objectives: Although the mortality rate of pediatric acute respiratory distress syndrome (PARDS) continues to decrease, the increased incidence of clinical sequelae in survivors has become a focus of clinical practice. This study aimed to …
View article: Gut microbiome and serum short-chain fatty acids are associated with responses to chemo- or targeted therapies in Chinese patients with lung cancer
Gut microbiome and serum short-chain fatty acids are associated with responses to chemo- or targeted therapies in Chinese patients with lung cancer Open
Background The association between gut microbes and short-chain fatty acids (SCFAs) and therapeutic responses of patients with lung cancer (LC) receiving therapy remains unknown. Methods Fecal and serum samples were prospectively collected…
View article: Roles of protein post-translational modifications in glucose and lipid metabolism: mechanisms and perspectives
Roles of protein post-translational modifications in glucose and lipid metabolism: mechanisms and perspectives Open
View article: A novel long noncoding <scp>RNA</scp> —lncRNA‐AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting <scp>MyD88</scp> in lipopolysaccharide‐induced myocardial depression
A novel long noncoding <span>RNA</span> —lncRNA‐AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting <span>MyD88</span> in lipopolysaccharide‐induced myocardial depression Open
Sepsis‐induced myocardial depression (SIMD) is common in pediatric intensive care units and seriously threatens children's health. Recently, long noncoding RNAs (lncRNAs) have been showed to play important roles in various diseases; howeve…
View article: Cellular and molecular biology of sirtuins in cardiovascular disease
Cellular and molecular biology of sirtuins in cardiovascular disease Open
Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+) -dependent histone deacetylase that regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified seven mammalian homologs of the yeast SIRT silencing…
View article: Transcriptome-wide identification of altered RNA m6A profiles in cardiac tissue of rats with LPS-induced myocardial injury
Transcriptome-wide identification of altered RNA m6A profiles in cardiac tissue of rats with LPS-induced myocardial injury Open
Purpose Myocardial injury is a common complication in patients with endotoxaemia/sepsis, especially in children. Moreover, it develops through an unclear pathophysiological mechanism, and effective therapies are lacking. Recently, RNA modi…
View article: Functional status of pediatric patients with trauma and risk factors for mortality from a single center in China
Functional status of pediatric patients with trauma and risk factors for mortality from a single center in China Open
Introduction The influence of reduced functional status has become increasingly relevant because of the gradual decline in mortality rate over the recent years. Nonetheless, only a few studies investigating the functional status of patient…
View article: Supplementary Figures and Tables from Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer
Supplementary Figures and Tables from Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer Open
Supplementary Figures S1-S8 and Tables S1-S3
View article: Supplementary Figures and Tables from Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer
Supplementary Figures and Tables from Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer Open
Supplementary Figures S1-S8 and Tables S1-S3
View article: Data from Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer
Data from Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer Open
The mechanisms responsible for radioresistance in pancreatic cancer have yet to be elucidated, and the suppressive tumor immune microenvironment must be considered. We investigated whether the radiotherapy-augmented Warburg effect helped m…
View article: Data from Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer
Data from Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer Open
The mechanisms responsible for radioresistance in pancreatic cancer have yet to be elucidated, and the suppressive tumor immune microenvironment must be considered. We investigated whether the radiotherapy-augmented Warburg effect helped m…
View article: Non-coding RNAs in metabolic reprogramming of bone and soft tissue sarcoma: Fundamental mechanism and clinical implication
Non-coding RNAs in metabolic reprogramming of bone and soft tissue sarcoma: Fundamental mechanism and clinical implication Open
Sarcomas, comprising approximately 1% of human malignancies, show a poor response to treatment and easy recurrence. Metabolic reprogramming play an important role in tumor development in sarcomas. Accumulating evidence shows that non-codin…
View article: Table S2 Details of the 414 difference expression proteins
Table S2 Details of the 414 difference expression proteins Open
Table S2 Details of the 414 difference expression proteins
View article: List of qPCR primers
List of qPCR primers Open
List of qPCR primers
View article: The sirtuin family in health and disease
The sirtuin family in health and disease Open
View article: Evaluation of SI, MSI and DSI for very early (3-day) mortality in patients with septic shock
Evaluation of SI, MSI and DSI for very early (3-day) mortality in patients with septic shock Open