Tiffany C. Y. Tang
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View article: Donor T cells for CAR T cell therapy
Donor T cells for CAR T cell therapy Open
View article: Characterizing piggyBat—a transposase for genetic modification of T cells
Characterizing piggyBat—a transposase for genetic modification of T cells Open
View article: Priming Leukemia with 5-Azacytidine Enhances CAR T Cell Therapy
Priming Leukemia with 5-Azacytidine Enhances CAR T Cell Therapy Open
We propose that treatment with AZA activates OX40L/OX40 co-stimulatory signaling in CAR T cells. Our data suggest that the clinical use of AZA before CAR T cells could be considered.
View article: Targeting the immune-suppressive tumor microenvironment to potentiate CAR T cell therapy
Targeting the immune-suppressive tumor microenvironment to potentiate CAR T cell therapy Open
Chimeric antigen receptor (CAR) T cell therapy is a promising new immunotherapy that reprograms patient T lymphocytes to specifically recognize and kill tumor cells.CAR T cell therapy has produced some dramatic responses in acute lymphobla…