Tao Cheng
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View article: Wogonin pretreatment of infrapatellar fat pad mesenchymal stem cell-derived exosomes advances articular cartilage repair in osteoarthritis
Wogonin pretreatment of infrapatellar fat pad mesenchymal stem cell-derived exosomes advances articular cartilage repair in osteoarthritis Open
Aims Osteoarthritis (OA) is a chronic joint disorder characterized by progressive cartilage degeneration, inflammation, and subchondral bone remodelling. Herein, the role of exosomes (Exos) extracted from wogonin-pretreated infrapatellar f…
View article: Extraperitoneal transvesical repair of a supratrigonal vesicovaginal fistula using transurethral illumination and laparoscopic instruments: A minimally invasive approach beyond transvaginal or transabdominal repair
Extraperitoneal transvesical repair of a supratrigonal vesicovaginal fistula using transurethral illumination and laparoscopic instruments: A minimally invasive approach beyond transvaginal or transabdominal repair Open
This is a 56-year-old woman with a history of endometrial cancer who underwent multiple abdominal gynecological surgeries and pelvic radiation therapy. She subsequently developed a 2-cm supratrigonal vesicovaginal fistula following transur…
View article: A Charge‐Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease
A Charge‐Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease Open
The exacerbation and recurrence of inflammatory bowel disease (IBD) are closely related to the overactivation of the immune system and the destruction of the intestinal mucosa. Current small‐molecule and biopharmaceutical therapies for IBD…
View article: FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise
FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise Open
Exercise maintains bone health and produces protective effects on bone loss. In this study, we investigated the potential protective effects of circulating small extracellular vesicles (sEVs) generated under endurance exercise training (Ex…
View article: Specific immune landscape of heatstroke distinguished from sepsis and aseptic inflammation
Specific immune landscape of heatstroke distinguished from sepsis and aseptic inflammation Open
Heatstroke is associated with immune system disturbances, which was similar to sepsis and aseptic inflammation. This study characterized the immune landscape of heatstroke and compared it to sepsis or aseptic inflammation in order to ident…
View article: Research progress on the role of bypass activation mechanisms in resistance to tyrosine kinase inhibitors in non-small cell lung cancer
Research progress on the role of bypass activation mechanisms in resistance to tyrosine kinase inhibitors in non-small cell lung cancer Open
The clinical application of small molecule tyrosine kinase inhibitors (TKIs) has significantly improved the quality of life and prognosis of patients with non-small cell lung cancer (NSCLC) carrying driver genes. However, resistance to TKI…
View article: Effects of Garlic on Glucose Parameters and Lipid Profile: A Systematic Review and Meta-Analysis on Randomized Controlled Trials
Effects of Garlic on Glucose Parameters and Lipid Profile: A Systematic Review and Meta-Analysis on Randomized Controlled Trials Open
(1) Background: The effect of garlic on glucose and lipid metabolism in humans remains controversial. The aim of this study was to investigate the effects of garlic on blood lipid levels and glucose levels in humans through a systematic re…
View article: Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty
Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty Open
Aims The present study aimed to investigate whether patients with inflammatory bowel disease (IBD) undergoing joint arthroplasty have a higher incidence of adverse outcomes than those without IBD. Methods A comprehensive literature search …
View article: Therapeutic effects of curcumin liposomes and nanocrystals on inflammatory osteolysis: In vitro and in vivo comparative study
Therapeutic effects of curcumin liposomes and nanocrystals on inflammatory osteolysis: In vitro and in vivo comparative study Open
Curcumin could inhibit periprosthetic osteolysis induced by wear debris and adherent endotoxin, which commonly cause prosthesis loosening and negatively influence the long-term survival of joint arthroplasty. However, its limited water sol…
View article: Preparation of photothermal-sensitive PDGF@ZIF-8-PDA@COL/PLGA-TCP composite scaffolds for bone defect repair
Preparation of photothermal-sensitive PDGF@ZIF-8-PDA@COL/PLGA-TCP composite scaffolds for bone defect repair Open
The repair of bone defects has long been a challenging and significant health question. Here, collagen hydrogel incorporating platelet-derived growth factor (PDGF)-loaded photopolymerizable ZIF-8-PDA nanoparticles (PDGF@ZIF-8-PDA@COL hydro…
View article: The Impact of Trace Elements on Osteoarthritis
The Impact of Trace Elements on Osteoarthritis Open
Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage degradation, synovial inflammation, subchondral sclerosis and osteophyte formation. It has a multifactorial etiology with potential contributions from her…
View article: Factors Affecting the Aluminum, Arsenic, Cadmium and Lead Concentrations in the Knee Joint Structures
Factors Affecting the Aluminum, Arsenic, Cadmium and Lead Concentrations in the Knee Joint Structures Open
Background: Toxic elements, such as aluminum (Al), arsenic (As), cadmium (Cd), and lead (Pb), are persistent environmental pollutants that can cause adverse effects on the health of exposed individuals. Bone is one of the primary target or…
View article: Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis
Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis Open
View article: Long-Term Follow-Up of Lichtenstein Repair of Inguinal Hernia in the Morbid Patients With Self-Gripping Mesh (ProgripTM)
Long-Term Follow-Up of Lichtenstein Repair of Inguinal Hernia in the Morbid Patients With Self-Gripping Mesh (ProgripTM) Open
Objective: This study aimed to demonstrate the safety and the efficacy of the self-gripping mesh (Progrip TM ) for inguinal hernia repair in morbid patients of the higher American Society of Anesthesiologists (ASA) classification (ASA III …
View article: Retraction Note: In vitro and in vivo responses of macrophages to magnesium-doped titanium
Retraction Note: In vitro and in vivo responses of macrophages to magnesium-doped titanium Open
View article: P37.32 Epigenetic Imprinted Genes as Biomarkers for the Proactive Detection and Accurate Presurgical Diagnosis of Small Lung Nodules
P37.32 Epigenetic Imprinted Genes as Biomarkers for the Proactive Detection and Accurate Presurgical Diagnosis of Small Lung Nodules Open
View article: Abdominal intercostal hernia repair
Abdominal intercostal hernia repair Open
Abdominal intercostal hernia (AIH) is a rare disease, may occur secondary to trauma or previous surgery, recently. There is no consensus on the best treatment of AIH. The aim of the present study is to report the repair of AIH in a male pa…
View article: Incidence and risk factors of delirium after percutaneous coronary intervention in individuals hospitalised for acute myocardial infarction: protocol for a systematic review and meta-analysis
Incidence and risk factors of delirium after percutaneous coronary intervention in individuals hospitalised for acute myocardial infarction: protocol for a systematic review and meta-analysis Open
Introduction Delirium in the postoperative period is a wide-reaching problem that affects important clinical outcomes. The incidence and risk factors of delirium in individuals with acute myocardial infarction (AMI) after primary percutane…
View article: Recombinant human bone morphogenetic protein-7 enhances bone formation ability of jaw bone defect using human umbilical cord mesenchymal stem cells combined with nano-hydroxyapatite/collagen/poly(L-lactide)
Recombinant human bone morphogenetic protein-7 enhances bone formation ability of jaw bone defect using human umbilical cord mesenchymal stem cells combined with nano-hydroxyapatite/collagen/poly(L-lactide) Open
Background: Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been suggested as an alternative source of MSCs. However, the studies on its bone formation ability in oral maxillo-facial bone defect are rare. This study investigate…
View article: Laparoscopic total extraperitoneal obturator hernia repair in critical challenging patients
Laparoscopic total extraperitoneal obturator hernia repair in critical challenging patients Open
AIM AND PERSPECTIVE: Obturator hernia is an uncommon surgical disease, a condition predominantly affected the elderly, emaciated, female patients. Various surgical procedures have been used to treat this disease, including open and laparos…
View article: Inguinal hernia repair in cirrhotic patients with ascites
Inguinal hernia repair in cirrhotic patients with ascites Open
AIM: Cirrhotic patients with ascites have a high incidence of abdominal wall hernias and carry an elevated perioperative morbidity and mortality. The optimal surgical treatment as well as timing of inguinal hernia repair in this situation …
View article: Curcumin has immunomodulatory effects on RANKL‐stimulated osteoclastogenesis in vitro and titanium nanoparticle‐induced bone loss in vivo
Curcumin has immunomodulatory effects on RANKL‐stimulated osteoclastogenesis in vitro and titanium nanoparticle‐induced bone loss in vivo Open
Wear particle‐stimulated inflammatory bone destruction and the consequent aseptic loosening remain the primary causes of artificial prosthesis failure and revision. Previous studies have demonstrated that curcumin has a protective effect o…
View article: Puerarin Exerts Protective Effects on Wear Particle-Induced Inflammatory Osteolysis
Puerarin Exerts Protective Effects on Wear Particle-Induced Inflammatory Osteolysis Open
Wear particle-stimulated inflammatory bone destruction and the consequent aseptic loosening remain major postoperative problems for artificial joints. Studies have indicated that puerarin promotes osteogenesis and alleviates lipopolysaccha…
View article: P1.09-12 In-Situ Hybridization Visual Scoring of Epigenetic Imprinting Genes Improves Early Diagnosis and Grading of Lung Cancers
P1.09-12 In-Situ Hybridization Visual Scoring of Epigenetic Imprinting Genes Improves Early Diagnosis and Grading of Lung Cancers Open
View article: <p>Lithium chloride with immunomodulatory function for regulating titanium nanoparticle-stimulated inflammatory response and accelerating osteogenesis through suppression of MAPK signaling pathway</p>
Lithium chloride with immunomodulatory function for regulating titanium nanoparticle-stimulated inflammatory response and accelerating osteogenesis through suppression of MAPK signaling pathway Open
LiCl has the immunomodulatory effects to alleviate Ti nanoparticle-mediated inflammatory reactions and enhance the osteogenic differentiation of rBMSCs by driving macrophage polarization. Thus, LiCl may be an effective therapeutic alternat…
View article: Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways
Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways Open
These results suggest that Sim may alleviate intestinal ischemia/reperfusion injury by modulating Omi/HtrA2 signaling pathways.
View article: Laparoscopic total extraperitoneal superior and inferior lumbar hernias repair without traumatic fixation: Two case reports
Laparoscopic total extraperitoneal superior and inferior lumbar hernias repair without traumatic fixation: Two case reports Open
BACKGROUND: The lumbar area is limited by the bone structures (superiorly by the 12th rib and inferiorly by the iliac crest); furthermore, several important nerves, including the genitofemoral nerve, lateral femoral cutaneous nerve, and il…
View article: Uterus-containing inguinal hernia caused by undue tension on round ligament
Uterus-containing inguinal hernia caused by undue tension on round ligament Open
The presence of uterus in inguinal hernia sac is a rare condition, the cause for this disease has not been clarified, and the contributions to this condition could be multiple. In this report, we described a case of a 78-year-old multiparo…
View article: New insights into the role of Methionine 199 in the function of Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) and bone homeostasis
New insights into the role of Methionine 199 in the function of Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) and bone homeostasis Open
Bone is a connective tissue that undergoes constant remodeling. Any disturbances during this process may result in undesired pathological conditions. A single nucleotide substitution (596T-A) in ex...
View article: Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects
Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects Open
Chronic osteomyelitis and infected bone defects are substantial challenges faced by orthopaedic surgeons. In this study, vancomycin was loaded into mesoporous bioactive glass (MBG) to form a local antibiotic delivery system and then a bone…