Tiffany Marchiol
YOU?
Author Swipe
View article: Genetic deregulation of <i>REL</i> in germinal center B cells induces generation of a pool of lymphoma precursor cells
Genetic deregulation of <i>REL</i> in germinal center B cells induces generation of a pool of lymphoma precursor cells Open
In diffuse large B-cell lymphomas (DLBCLs), gains and amplifications of the 2p15-16 region, which always encompass the REL gene, are mostly restricted to the germinal center (GC) B-cell DLBCL subtype (GCB-DLBCL) for which c-Rel is the pivo…
View article: Activated mature B cells undergo enforced Sµ-3'RRrec in the λ-c-MYC mouse model
Activated mature B cells undergo enforced Sµ-3'RRrec in the λ-c-MYC mouse model Open
The Sµ-3'RR recombination (Sµ-3'RRrec) in B cells, a genomic rearrangement occurring within the immunoglobulin heavy chain (IGH) locus is believed to lead to B cell receptor (BCR) loss. Its increased frequency in patients with chronic lymp…
View article: <i>REL</i>deregulation stands as a primary hit for AID-imprinted B-cells along the germinal center competition
<i>REL</i>deregulation stands as a primary hit for AID-imprinted B-cells along the germinal center competition Open
In diffuse large B-cell lymphomas (DLBCLs), gains and amplifications of the 2p15-16 region, which always encompass the REL gene, are mostly restricted to the germinal center (GC) B- cell DLBCL subtype (GCB-DLBCL) for which c-Rel is the piv…
View article: Attempts to evaluate locus suicide recombination and its potential role in B cell negative selection in the mouse
Attempts to evaluate locus suicide recombination and its potential role in B cell negative selection in the mouse Open
Introduction In mature B cells, activation-induced deaminase reshapes Ig genes through somatic hypermutation and class switch recombination of the Ig heavy chain ( IgH ) locus under control of its 3’ cis -regulatory region ( 3’RR ). The 3’…
View article: Distinct B-Cell Specific Transcriptional Contexts of the BCL2 Oncogene Impact Pre-Malignant Development in Mouse Models
Distinct B-Cell Specific Transcriptional Contexts of the BCL2 Oncogene Impact Pre-Malignant Development in Mouse Models Open
Upregulated expression of the anti-apoptotic BCL2 oncogene is a common feature of various types of B-cell malignancies, from lymphoma to leukemia or myeloma. It is currently unclear how the various patterns of deregulation observed in path…
View article: <scp>NLRP6</scp> negatively regulates type 2 immune responses in mice
<span>NLRP6</span> negatively regulates type 2 immune responses in mice Open
Background Inflammasomes are large protein complexes that assemble in the cytosol in response to danger such as tissue damage or infection. Following activation, inflammasomes trigger cell death and the release of biologically active forms…
View article: Homozygous iMycCα transgenic mice as a model of plasma B-cell lymphomas
Homozygous iMycCα transgenic mice as a model of plasma B-cell lymphomas Open
The 3' regulatory region (3'RR) located downstream from the Cα gene is the conductor of transcription, accessibility, and remodeling of the IgH locus at mature B-cell stages. Convincing demonstrations of the essential contributions of the …
View article: Diverse B-cell specific transcriptional contexts of the BCL2 oncogene in mouse models impacts pre-malignant development
Diverse B-cell specific transcriptional contexts of the BCL2 oncogene in mouse models impacts pre-malignant development Open
Follicular lymphoma (FL) is the most common indolent form of non-Hodgkin lymphoma arising from malignant germinal center (GC) B-cells. The genetic hallmark that leads to the development of FL is the t(14:18) which occurs early in the bone …
View article: HDAC/HDACi, IgH 3’RR Enhancers, B-Cells and B-Cell Lymphomas
HDAC/HDACi, IgH 3’RR Enhancers, B-Cells and B-Cell Lymphomas Open
View article: Chronic <i>Pseudomonas aeruginosa</i> Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
Chronic <i>Pseudomonas aeruginosa</i> Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling Open
Cystic fibrosis is associated with chronic Pseudomonas aeruginosa colonization and inflammation. The role of MyD88, the shared adapter protein of the proinflammatory TLR and IL-1R families, in chronic P. aeruginosa biofilm lung infection i…
View article: Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation
Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation Open
The cysteine protease caspase-1 (Casp-1) contributes to innate immunity through the assembly of NLRP3, NLRC4, AIM2, and NLRP6 inflammasomes. Here we ask whether caspase-1 activation plays a regulatory role in house dust mite (HDM)-induced …