Tiina Holster
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View article: Serum IgG1 and IgG3 Antibodies to <i>Chlamydia trachomatis</i> Pgp3 and Hsp60 in Men of Subfertile Couples
Serum IgG1 and IgG3 Antibodies to <i>Chlamydia trachomatis</i> Pgp3 and Hsp60 in Men of Subfertile Couples Open
Background Our goal was to investigate immunoglobulin G1 (IgG1) and immunoglobulin G3 (IgG3) antibody responses to Chlamydia trachomatis proteins Pgp3 and Hsp60 in males of subfertile couples and to explore the association of these antibod…
View article: Serum IgG1 and IgG3 Antibody Responses to <i>Chlamydia trachomatis</i> Pgp3 and Hsp60 in Tubal Factor Infertility
Serum IgG1 and IgG3 Antibody Responses to <i>Chlamydia trachomatis</i> Pgp3 and Hsp60 in Tubal Factor Infertility Open
Background Our goal was to investigate IgG1 and IgG3 antibody responses to Chlamydia trachomatis proteins Pgp3 and Hsp60 in women with tubal factor infertility (TFI). Our goal was to determine the role of these biomarkers in the diagnosis …
View article: Metagenome-validated combined amplicon sequencing and text mining-based annotations for simultaneous profiling of bacteria and fungi: vaginal microbiota and mycobiota in healthy women
Metagenome-validated combined amplicon sequencing and text mining-based annotations for simultaneous profiling of bacteria and fungi: vaginal microbiota and mycobiota in healthy women Open
Background Amplicon sequencing of kingdom-specific tags such as 16S rRNA gene for bacteria and internal transcribed spacer (ITS) region for fungi are widely used for investigating microbial communities. So far most human studies have focus…
View article: Increased type 1 inflammation in gynecologic cervicovaginal samples in patients with APS-1
Increased type 1 inflammation in gynecologic cervicovaginal samples in patients with APS-1 Open
Excessive TH1 cell response appears to underlie disruption of the mucosal immune responses in the genital tract of patients with APS-1 and may contribute to susceptibility to candidiasis in the genital tract as well.
View article: Longitudinal analysis of vaginal microbiota during IVF fresh embryo transfer and in early pregnancy
Longitudinal analysis of vaginal microbiota during IVF fresh embryo transfer and in early pregnancy Open
Non- Lactobacillus -dominated vaginal microbiota has been associated with poor gynecologic health and complications during pregnancy. Lactobacilli and especially Lactobacillus crispatus associate with good reproductive health and dominate …
View article: Immunological Markers of<i>Chlamydia trachomatis</i>Infection in Epithelial Ovarian Cancer
Immunological Markers of<i>Chlamydia trachomatis</i>Infection in Epithelial Ovarian Cancer Open
Women with EOC and positive markers of persistent C. trachomatis infection have better response to the first-line treatment and seem to have better three-year survival.
View article: Metagenome-validated Parallel Amplicon Sequencing and Text Mining-based Annotations for Simultaneous Profiling of Bacteria and Fungi: Vaginal Microbiota and Mycobiota in Healthy Women
Metagenome-validated Parallel Amplicon Sequencing and Text Mining-based Annotations for Simultaneous Profiling of Bacteria and Fungi: Vaginal Microbiota and Mycobiota in Healthy Women Open
Background Amplicon sequencing of kingdom-specific tags such as 16S rRNA gene for bacteria and internal transcribed spacer (ITS) region for fungi are widely used for investigating microbial communities. So far most human studies have focus…
View article: O-258 Characterization of vaginal microbiota during IVF fresh embryo transfer (IVF-ET) and in early pregnancy
O-258 Characterization of vaginal microbiota during IVF fresh embryo transfer (IVF-ET) and in early pregnancy Open
Study question Does the composition of vaginal microbiota affect the success of IVF-ET? Does vaginal microbiota profile change intra-individually from IVF-ET to early pregnancy? Summary answer L. crispatus is associated with successful IVF…
View article: Cervicovaginal Complement Activation and Microbiota During Pregnancy and in Parturition
Cervicovaginal Complement Activation and Microbiota During Pregnancy and in Parturition Open
Background Vaginal microbiome and the local innate immune defense, including the complement system, contribute to anti- and proinflammatory homeostasis during pregnancy and parturition. The relationship between commensal vaginal bacteria a…
View article: O-303 Recurrent pregnancy loss is associated with unfavorable composition of endometrial and vaginal microbiota
O-303 Recurrent pregnancy loss is associated with unfavorable composition of endometrial and vaginal microbiota Open
Study question Does endometrial or vaginal microbiota composition associate with recurrent pregnancy loss (RPL)? Summary answer Reduced relative abundance of Lactobacillus crispatus in endometrium and increased relative abundance of Gardne…
View article: Parity and gestational age are associated with vaginal microbiota composition in term and late term pregnancies
Parity and gestational age are associated with vaginal microbiota composition in term and late term pregnancies Open
This research was supported by EU H2020 programme Sweet Crosstalk ITN (814102), Academy of Finland, State Research Funding, and University of Helsinki.
View article: Female reproductive tract microbiota and recurrent pregnancy loss: a nested case-control study
Female reproductive tract microbiota and recurrent pregnancy loss: a nested case-control study Open
Dysbiosis of the reproductive tract microbiota is associated with RPL and may represent a novel risk factor for pregnancy losses.
View article: Parity and gestational age are associated with vaginal microbiota composition in term and late term pregnancies
Parity and gestational age are associated with vaginal microbiota composition in term and late term pregnancies Open
Vaginal microbiota and its potential contribution to preterm birth has been under intense research in recent years. However, only few studies have studied vaginal microbiota in later stages of pregnancy or at the onset of labor. We analyze…