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View article: PATH-75. Hetairos enables AI-based histopathological classification of CNS tumours
PATH-75. Hetairos enables AI-based histopathological classification of CNS tumours Open
Central nervous system (CNS) tumours encompass a diverse group of neoplasms with complex histological and molecular profiles. DNA methylation profiling has revolutionised their classification, enabling diagnosis at granular resolution. How…
View article: OS12.4.A AI-BASED HISTOPATHOLOGICAL CLASSIFICATION OF CENTRAL NERVOUS SYSTEM TUMOURS
OS12.4.A AI-BASED HISTOPATHOLOGICAL CLASSIFICATION OF CENTRAL NERVOUS SYSTEM TUMOURS Open
BACKGROUND DNA methylation profiling is central to CNS tumour diagnostics, providing molecular classification beyond conventional histopathology. However, its use is constrained by extended turnaround time, high costs and the need for spec…
View article: Advancing sarcoma diagnostics with expanded DNA methylation-based classification
Advancing sarcoma diagnostics with expanded DNA methylation-based classification Open
Purpose Sarcomas pose a severe diagnostic challenge. A wide variety of these distinct entities need to be distinguished from each other and from less aggressive types of mesenchymal tumors, to ensure correct clinical management. A machine …
View article: RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α Open
Defective DNA repair and metabolic rewiring are highly intertwined in promoting the development and progression of cancer. However, the molecular players at their interface remain poorly understood. Here we show that an RNF20-HIF1α axis li…
View article: Integration of an automated cell culture analyzer with a closed-system hollow-fiber bioreactor for online metabolite detection and cell monitoring
Integration of an automated cell culture analyzer with a closed-system hollow-fiber bioreactor for online metabolite detection and cell monitoring Open
Background: On-line sensing technologies for expanding cell cultures are becoming essential tools for understanding metabolic activity during critical stages of expansion. These tools generate data that indicate when user interventions are…
View article: AI-based histopathological classification of central nervous system tumours
AI-based histopathological classification of central nervous system tumours Open
DNA methylation analysis has become an essential diagnostic assay for classifying tumours of the central nervous system (CNS). However, this test requires additional resources and time compared to conventional histopathological diagnosis u…
View article: Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis
Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis Open
Veins have emerged as the origin of all other endothelial cell subtypes needed to expand vascular networks during developmental and pathological neoangiogenesis. Here, we uncover the role of the angioneurin Fibronectin Leucine Rich Transme…
View article: MOTH: Memory-Efficient On-the-Fly Tiling of Histological Image Annotations Using QuPath
MOTH: Memory-Efficient On-the-Fly Tiling of Histological Image Annotations Using QuPath Open
The emerging usage of digitalized histopathological images is leading to a novel possibility for data analysis. With the help of artificial intelligence algorithms, it is now possible to detect certain structures and morphological features…
View article: P18.26.A IMPROVED OUTCOME PREDICTION AND GRADING OF THE NOVEL TUMOUR TYPE GLIOMATOSIS CEREBRI-LIKE GLIOMA, IDH-WILDTYPE (GCLG, IDH-WT)
P18.26.A IMPROVED OUTCOME PREDICTION AND GRADING OF THE NOVEL TUMOUR TYPE GLIOMATOSIS CEREBRI-LIKE GLIOMA, IDH-WILDTYPE (GCLG, IDH-WT) Open
BACKGROUND Based on a cohort of 16 patients, we recently described a novel tumour type of IDH-wildtype glioma in adult patients, characterised by a gliomatosis cerebri-like growth pattern, frequent TERT promoter mutations, and a distinct e…
View article: Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis
Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis Open
Veins have emerged as the origin of all other endothelial cell subtypes needed to expand vascular networks during developmental and pathological neoangiogenesis. Here, we uncover the significant role of the angioneurin Fibronectin Leucine …
View article: EPEN-14. MOLECULAR MARKERS AND PREDICTORS OF OUTCOME FOR PAEDIATRIC INTRACRANIAL EPENDYMOMA IN THE PROSPECTIVE, MULTICENTRE E-HIT2000 TRIAL AND SUBSEQUENT HIT-REGISTRIES: A POOLED ANALYSIS OF 244 PATIENTS
EPEN-14. MOLECULAR MARKERS AND PREDICTORS OF OUTCOME FOR PAEDIATRIC INTRACRANIAL EPENDYMOMA IN THE PROSPECTIVE, MULTICENTRE E-HIT2000 TRIAL AND SUBSEQUENT HIT-REGISTRIES: A POOLED ANALYSIS OF 244 PATIENTS Open
BACKGROUND Throughout the past decade, molecular tools have revolutionised ependymoma classification, yet their application has been limited in clinical trial cohorts. METHODS We present the molecular analysis of paediatric ependymoma pati…
View article: Outcome of whole brain irradiation with a dose-escalated simultaneous-integrated boost in patients with multiple large and/or diffuse brain metastases: real live data and review of the literature
Outcome of whole brain irradiation with a dose-escalated simultaneous-integrated boost in patients with multiple large and/or diffuse brain metastases: real live data and review of the literature Open
Background : We retrospectively investigate feasibility and safety of whole brain radiotherapy (WBRT) including a simultaneous-integrated boost technique (WBRT-SIB) in a cohort of patients with a very poor prognosis suffering from multiple…
View article: DistSNE: Distributed computing and online visualization of DNA methylation‐based central nervous system tumor classification
DistSNE: Distributed computing and online visualization of DNA methylation‐based central nervous system tumor classification Open
The current state‐of‐the‐art analysis of central nervous system (CNS) tumors through DNA methylation profiling relies on the tumor classifier developed by Capper and colleagues, which centrally harnesses DNA methylation data provided by us…
View article: Beyond ribosome biogenesis: noncoding nucleolar RNAs in physiology and tumor biology
Beyond ribosome biogenesis: noncoding nucleolar RNAs in physiology and tumor biology Open
The nucleolus, the largest subcompartment of the nucleus, stands out from the nucleoplasm due to its exceptionally high local RNA and low DNA concentrations. Within this central hub of nuclear RNA metabolism, ribosome biogenesis is the mos…
View article: Leveraging Attention-Based Convolutional Neural Networks for Meningioma Classification in Computational Histopathology
Leveraging Attention-Based Convolutional Neural Networks for Meningioma Classification in Computational Histopathology Open
Convolutional neural networks (CNNs) are becoming increasingly valuable tools for advanced computational histopathology, promoting precision medicine through exceptional visual decoding abilities. Meningiomas, the most prevalent primary in…
View article: Distribution of ferritin complex in the adult brain and altered composition in neuroferritinopathy due to a novel variant in the ferritin heavy chain gene <scp><i>FTH1</i></scp> (c.409_410del; p.<scp>H137Lfs</scp>*4)
Distribution of ferritin complex in the adult brain and altered composition in neuroferritinopathy due to a novel variant in the ferritin heavy chain gene <span><i>FTH1</i></span> (c.409_410del; p.<span>H137Lfs</span>*4) Open
Ferritin is an iron-binding, spherical protein complex consisting of 24 light (FTL) and heavy (FTH) chain subunits. The proportion of FTL and FTH is determined by tissue and cell differentiation (Figure S1). FTL conveys the iron-storage fu…
View article: Supplementary Figures 1-7 and Supplementary Methods from PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα
Supplementary Figures 1-7 and Supplementary Methods from PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα Open
Supplementary Figure S1. Epithelial-mesenchymal transition and PHD3 silencing | Supplementary Figure S2. PHD3 silencing promotes EMT through upregulation of TGFα. | Supplementary Figure S3. EGFR signaling and TGFα mediate the effects of PH…
View article: Supplementary Figures 1-7 and Supplementary Methods from PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα
Supplementary Figures 1-7 and Supplementary Methods from PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα Open
Supplementary Figure S1. Epithelial-mesenchymal transition and PHD3 silencing | Supplementary Figure S2. PHD3 silencing promotes EMT through upregulation of TGFα. | Supplementary Figure S3. EGFR signaling and TGFα mediate the effects of PH…
View article: Data from PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα
Data from PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα Open
Lung cancer is the leading cause of cancer-related death worldwide, in large part due to its high propensity to metastasize and to develop therapy resistance. Adaptive responses to hypoxia and epithelial–mesenchymal transition (EMT) are li…
View article: Data from PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα
Data from PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα Open
Lung cancer is the leading cause of cancer-related death worldwide, in large part due to its high propensity to metastasize and to develop therapy resistance. Adaptive responses to hypoxia and epithelial–mesenchymal transition (EMT) are li…
View article: Supplementary Materials and Methods and Supplementary Figures 1 through 5 from Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma
Supplementary Materials and Methods and Supplementary Figures 1 through 5 from Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma Open
Supplementary Information including: Supplementary Materials and Methods Supplementary References Supplementary Figure S1: Expression of HIF and HIF target genes in cells exposed to varying O2, CO2 and glucose levels. Supplementary Figure …
View article: Data from Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors
Data from Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors Open
Adaptive responses to hypoxia in tumors are transcriptionally regulated by the hypoxia inducible factors (HIF-1α/HIF-2α), which are tightly controlled by the HIF-prolyl hydroxylases (PHD). Hypoxia induces expression of the PHD2 and PHD3 pr…
View article: Data from Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma
Data from Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma Open
Hypoxia is a common feature of solid tumors, which controls multiple aspects of cancer progression. One important function of hypoxia and the hypoxia-inducible factors (HIF) is the maintenance of cancer stem-like cells (CSC), a population …
View article: Supplementary Materials, Table 1, Figure Legends 1-7 from Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors
Supplementary Materials, Table 1, Figure Legends 1-7 from Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors Open
Supplementary Materials, Table 1, Figure Legends 1-7 from Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors