Till Strowig
YOU?
Author Swipe
View article: Interleukin-17A Mediates Cardiorenal Injury In Oxalate Nephropathy
Interleukin-17A Mediates Cardiorenal Injury In Oxalate Nephropathy Open
Aims Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD). While CKD is known to give rise to systemic inflammation, its inciting factors remain poorly defined. Oxalate, long implicated in rare gen…
View article: Gene-centric metagenomic analyses reveal microbiome functional insights into diseases
Gene-centric metagenomic analyses reveal microbiome functional insights into diseases Open
The microbiome encodes millions of genes; however, understanding their role in human health remains challenging. Here, we developed MetaGEAR, a gene-centric analysis framework for metagenomic data. MetaGEAR constructs cohort-specific datab…
View article: Of Mice and Men: Studying Innate and Adaptive Immunity Against the Epstein-Barr Virus
Of Mice and Men: Studying Innate and Adaptive Immunity Against the Epstein-Barr Virus Open
The Epstein-Barr virus (EBV) is a lymphotropic γ-herpes virus infecting over 90% of the human adult population. A striking feature that the virus shares with other γ-herpes viruses is its oncogenic potential. This transforming property can…
View article: Synergy between Enterobacteriaceae and dietary components shapes the competition between the dominant anaerobes of the human gut
Synergy between Enterobacteriaceae and dietary components shapes the competition between the dominant anaerobes of the human gut Open
The human gut microbiota is frequently dominated by the Bacteroidota phylum, with Bacteroidaceae and Prevotellaceae families prevailing in modern and traditional lifestyles, respectively. While these distinct profiles have been well-docume…
View article: Gut-specific histamine 3 receptor signaling orchestrates microglia-dependent resolution of peripheral inflammation
Gut-specific histamine 3 receptor signaling orchestrates microglia-dependent resolution of peripheral inflammation Open
Chronic inflammatory diseases like rheumatoid arthritis (RA) have been described to cause CNS activation. Less is known about environmental factors that enable the CNS to suppress peripheral inflammation in RA. Here, we identified gut micr…
View article: Suppression of gut colonization by multidrug-resistant Escherichia coli clinical isolates through cooperative niche exclusion
Suppression of gut colonization by multidrug-resistant Escherichia coli clinical isolates through cooperative niche exclusion Open
Human gut colonization by multi-drug resistant Enterobacterales (MDR-E) poses a risk for subsequent infections. Because of the collateral damage antibiotics cause to the microbiota, microbiome-based interventions aimed at promoting decolon…
View article: Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype
Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype Open
Conventional laboratory mice housed under specific pathogen-free (SPF) conditions are the standard model in biomedical research. However, in recent years, many rodent-based studies have been deemed irreproducible, raising questions about t…
View article: Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium Open
Isogenic bacteria can be phenotypically diverse. This heterogeneity is evident in the Bacteroidota, a predominant phylum of the human gut microbiota. These bacteria adopt diverse morphologies, yet the molecular basis of their morphological…
View article: A Comparison of the Effects of Milk, Yogurt, and Cheese on Insulin Sensitivity, Hepatic Steatosis, and Gut Microbiota in Diet-Induced Obese Male Mice
A Comparison of the Effects of Milk, Yogurt, and Cheese on Insulin Sensitivity, Hepatic Steatosis, and Gut Microbiota in Diet-Induced Obese Male Mice Open
The effects of low-fat dairy products on insulin resistance (IR), hepatic steatosis, and gut microbiota composition in high-fat diet (HFD)-fed obese mice were examined. C57BL/6 male mice (n = 16/group) were fed a high-fat diet (HFD, 45% fa…
View article: Author Correction: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Author Correction: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer Open
View article: HiBC: a publicly available collection of bacterial strains isolated from the human gut
HiBC: a publicly available collection of bacterial strains isolated from the human gut Open
View article: Mucosal innate immune activation as the trigger to <i>Prevotella</i> species-induced arthritis in genetically resistant mice
Mucosal innate immune activation as the trigger to <i>Prevotella</i> species-induced arthritis in genetically resistant mice Open
An altered gut microbiota, particularly the expansion of Prevotellaceae members, is increasingly implicated in the pathogenesis of rheumatoid arthritis (RA), yet the mechanisms hind this phenomenon remain unclear. Here, we demonstrate that…
View article: The impact of regular sauerkraut consumption on the human gut microbiota: a crossover intervention trial
The impact of regular sauerkraut consumption on the human gut microbiota: a crossover intervention trial Open
View article: Klebsiella oxytoca facilitates microbiome recovery via antibiotic degradation and restores colonization resistance in a diet-dependent manner
Klebsiella oxytoca facilitates microbiome recovery via antibiotic degradation and restores colonization resistance in a diet-dependent manner Open
Competition among bacteria for carbohydrates is pivotal for colonization resistance (CR). However, the impact of Western-style diets on CR remains unclear. Here we show how the competition between Klebsiella oxytoca and Klebsiella pneumoni…
View article: Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup
Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup Open
View article: High Abundance of Gut Bacteroides in Early Childhood correlates with Microbiome Stability and Resilience after Antibiotic Treatment and with Increased Risk for Childhood Infections
High Abundance of Gut Bacteroides in Early Childhood correlates with Microbiome Stability and Resilience after Antibiotic Treatment and with Increased Risk for Childhood Infections Open
Background Early childhood events, up to the age of two, are critical for the development of the microbiome and balanced immunity later in life. We investigated whether susceptibility to infections and microbiome resilience after antibioti…
View article: Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup
Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup Open
Diet significantly influences the human gut microbiota, a key player in health. We analyzed shotgun metagenomic sequencing data from healthy individuals with long-term dietary patterns-vegan, flexitarian, or omnivore-and included detailed …
View article: Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts Open
Although diet is a substantial determinant of the human gut microbiome, the interplay between specific foods and microbial community structure remains poorly understood. Coffee is a habitually consumed beverage with established metabolic a…
View article: Correction to: The RESIST Senior Individuals Cohort: Design, participant characteristics and aims
Correction to: The RESIST Senior Individuals Cohort: Design, participant characteristics and aims Open
View article: The RESIST Senior Individuals Cohort: Design, participant characteristics and aims
The RESIST Senior Individuals Cohort: Design, participant characteristics and aims Open
View article: Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19 Open
View article: Comparative analysis of the treatment-naïve microbiome across rheumatic diseases to predict MTX treatment response
Comparative analysis of the treatment-naïve microbiome across rheumatic diseases to predict MTX treatment response Open
The human gut microbiota is recognized as a modulator of inflammatory diseases and has been linked to interindividual differences in therapy responsiveness. However, the robustness of disease-specific microbiome signatures across closely r…
View article: An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile
An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile Open
Antimicrobial resistance (AMR) has been emerging as a major global health threat and calls for the development of novel drug candidates. Metal complexes have been demonstrating high efficiency as antibacterial agents that differ substantia…
View article: Broad diversity of human gut bacteria accessible via a traceable strain deposition system
Broad diversity of human gut bacteria accessible via a traceable strain deposition system Open
Numerous bacteria in the human gut microbiome remain unknown and/or have yet to be cultured. While collections of human gut bacteria have been published, few strains have been made publicly available. A major hurdle in making strains publi…
View article: Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms
Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms Open
View article: Author Correction: c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis
Author Correction: c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis Open
View article: The RESIST Senior Individuals Cohort: Design, participant characteristics and aims
The RESIST Senior Individuals Cohort: Design, participant characteristics and aims Open
The number of older adults worldwide is growing exponentially. However, while living longer, older individuals are more susceptible to both non-infectious and infectious diseases, at least in part due to alterations of the immune system. H…
View article: Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes
Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes Open
View article: Systematic interrogation of CRISPR antimicrobials in <i>Klebsiella pneumoniae</i> reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity
Systematic interrogation of CRISPR antimicrobials in <i>Klebsiella pneumoniae</i> reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity Open
CRISPR-Cas systems can be utilized as programmable-spectrum antimicrobials to combat bacterial infections. However, how CRISPR nucleases perform as antimicrobials across target sites and strains remains poorly explored. Here, we address th…
View article: The RNA landscape of the human commensal<i>Segatella copri</i>reveals a small RNA essential for gut colonization
The RNA landscape of the human commensal<i>Segatella copri</i>reveals a small RNA essential for gut colonization Open
Summary The bacterium Segatella copri is a prevalent member of the human gut microbiota associated with both health and disease states, but intrinsic factors that determine its ability to effectively colonize the gut are not understood. By…