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View article: Kinetics of the thapsigargin-induced Ca2+ mobilisation: A quantitative analysis in the HEK-293 cell line
Kinetics of the thapsigargin-induced Ca2+ mobilisation: A quantitative analysis in the HEK-293 cell line Open
Thapsigargin (TG) inhibits the sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA) pump and, when applied acutely, it initiates a Ca 2+ mobilisation that begins with the loss of Ca 2+ from the endoplasmic reticulum (ER) and culminates with st…
View article: Antagonizing Sec62 function in intracellular Ca2+ homeostasis represents a novel therapeutic strategy for head and neck cancer
Antagonizing Sec62 function in intracellular Ca2+ homeostasis represents a novel therapeutic strategy for head and neck cancer Open
Various cancer types including head and neck squamous cell carcinomas (HNSCC) show a frequent amplification of chromosomal region 3q26 that encodes, among others, for the SEC62 gene. Located in the ER membrane, this translocation protein i…
View article: Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state Open
The Mycobacterium ulcerans exotoxin, mycolactone, is an inhibitor of co-translational translocation via the Sec61 complex. Mycolactone has previously been shown to bind to, and alter the structure of the major translocon subunit Sec61α, an…
View article: Remodelling of Ca2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells
Remodelling of Ca2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells Open
The endoplasmic reticulum (ER) is extensively remodelled during the development of professional secretory cells to cope with high protein production. Since ER is the principal Ca2+ store in the cell, we characterised the Ca2+ homeostasis i…
View article: Mycolactone enhances the Ca<sup>2+</sup> leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca<sup>2+</sup> permeable state
Mycolactone enhances the Ca<sup>2+</sup> leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca<sup>2+</sup> permeable state Open
The Mycobacterium ulcerans exotoxin, mycolactone, is an inhibitor of co-translational translocation via the Sec61 complex. Mycolactone has previously been shown to bind to, and alter the structure of, the major translocon subunit Sec61α, a…
View article: Eeyarestatin 24 impairs SecYEG‐dependent protein trafficking and inhibits growth of clinically relevant pathogens
Eeyarestatin 24 impairs SecYEG‐dependent protein trafficking and inhibits growth of clinically relevant pathogens Open
Eeyarestatin 1 (ES1) is an inhibitor of endoplasmic reticulum (ER) associated protein degradation, Sec61‐dependent Ca 2+ homeostasis and protein translocation into the ER. Recently, evidence was presented showing that a smaller analog of E…