Tilman Schmoll
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View article: Demystifying the feasibility of in vivo nonresonant Raman spectroscopy of the human retina
Demystifying the feasibility of in vivo nonresonant Raman spectroscopy of the human retina Open
Early detection of retinal molecular biomarkers is crucial for addressing the unmet clinical need to prevent irreversible neural tissue damage in ophthalmic and neurodegenerative diseases. Among emerging molecular sensing techniques, non-r…
View article: Context-Aware Real-Time Semantic View Expansion of Intraoperative 4D OCT
Context-Aware Real-Time Semantic View Expansion of Intraoperative 4D OCT Open
Four-dimensional microscope-integrated optical coherence tomography enables volumetric imaging of tissue structures and tool-tissue interactions in ophthalmic surgery at interactive update rates. This enables surgeons to undertake particul…
View article: Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina
Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina Open
In vivo access to molecular information of retinal tissue is considered to play a critical role in enabling early diagnosis of ophthalmic and neurodegenerative diseases. The current gold standard of retina imaging, optical coherence tomogr…
View article: Introduction and Validation of Low-Cost Ocular Biometry in Healthy and Cataractous Eyes Using a Thermally Tunable Swept-Source Laser
Introduction and Validation of Low-Cost Ocular Biometry in Healthy and Cataractous Eyes Using a Thermally Tunable Swept-Source Laser Open
Optical biometry using a thermally tunable VCSEL swept-source light source has the potential to provide clinically relevant biometric parameters at an unprecedented 100-fold lower price point than currently used state-of-the-art optical bi…
View article: Association of microaneurysms with retinal vascular alterations in patients with retinal vein occlusion
Association of microaneurysms with retinal vascular alterations in patients with retinal vein occlusion Open
MAs were associated with extensive NPA, the presence of CV, GV, and TV. There was no correlation between the diameter of the MA and the adjacent intraretinal fluid in our predominantly pretreated RVO study patients.
View article: Exploring single-mode VCSEL wavelength tuning for low-cost 3D optical coherence tomography and OCT angiography
Exploring single-mode VCSEL wavelength tuning for low-cost 3D optical coherence tomography and OCT angiography Open
Low-cost optical coherence tomography has recently emerged as a growing field due to the increased need for general availability of OCT devices outside of the clinics. One of the main obstacles in creating low-cost SS-OCT systems is the pr…
View article: Visualization of Cataract Surgery Steps With 4D Microscope-Integrated Swept-Source Optical Coherence Tomography in Ex Vivo Porcine Eyes
Visualization of Cataract Surgery Steps With 4D Microscope-Integrated Swept-Source Optical Coherence Tomography in Ex Vivo Porcine Eyes Open
We demonstrate the visualization capabilities of a cutting edge swept-source OCT system integrated into an ophthalmic surgical microscope during cataract surgery.
View article: Microaneurysm detection using high‐speed megahertz optical coherence tomography angiography in advanced diabetic retinopathy
Microaneurysm detection using high‐speed megahertz optical coherence tomography angiography in advanced diabetic retinopathy Open
Purpose To compare detection rates of microaneurysms (MAs) on high‐speed megahertz optical coherence tomography angiography (MHz‐OCTA), fluorescein angiography (FA) and colour fundus photography (CF) in patients with diabetic retinopathy (…
View article: Association of Diabetic Lesions and Retinal Nonperfusion Using Widefield Multimodal Imaging
Association of Diabetic Lesions and Retinal Nonperfusion Using Widefield Multimodal Imaging Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Multiple instance learning based classification of diabetic retinopathy in weakly-labeled widefield OCTA en face images
Multiple instance learning based classification of diabetic retinopathy in weakly-labeled widefield OCTA en face images Open
Diabetic retinopathy (DR), a pathologic change of the human retinal vasculature, is the leading cause of blindness in working-age adults with diabetes mellitus. Optical coherence tomography angiography (OCTA), a functional extension of opt…
View article: Live 4D-OCT denoising with self-supervised deep learning
Live 4D-OCT denoising with self-supervised deep learning Open
By providing three-dimensional visualization of tissues and instruments at high resolution, live volumetric optical coherence tomography (4D-OCT) has the potential to revolutionize ophthalmic surgery. However, the necessary imaging speed i…
View article: Surgical microscope integrated MHz SS-OCT with live volumetric visualization
Surgical microscope integrated MHz SS-OCT with live volumetric visualization Open
Intraoperative optical coherence tomography is still not overly pervasive in routine ophthalmic surgery, despite evident clinical benefits. That is because today’s spectral-domain optical coherence tomography systems lack flexibility, acqu…
View article: Ultra-Widefield OCT Angiography
Ultra-Widefield OCT Angiography Open
Optical Coherence Tomography Angiography (OCTA), a functional extension of OCT, has the potential to replace most invasive fluorescein angiography (FA) exams in ophthalmology. So far, OCTA's field of view is however still lacking behind fl…
View article: Detection of diabetic neovascularisation using single-capture 65°-widefield optical coherence tomography angiography
Detection of diabetic neovascularisation using single-capture 65°-widefield optical coherence tomography angiography Open
Aim To assess the detection rate of retinal neovascularisation (NV) in eyes with proliferative diabetic retinopathy (PDR) using widefield optical coherence tomography angiography (WF-OCTA) in comparison to ultrawidefield fluorescein angiog…
View article: Data-centric AI approach to improve optic nerve head segmentation and localization in OCT en face images
Data-centric AI approach to improve optic nerve head segmentation and localization in OCT en face images Open
The automatic detection and localization of anatomical features in retinal imaging data are relevant for many aspects. In this work, we follow a data-centric approach to optimize classifier training for optic nerve head detection and local…
View article: Miniaturizing optical coherence tomography
Miniaturizing optical coherence tomography Open
Optical coherence tomography (OCT) has revolutionized ophthalmic diagnosis as a non‐invasive, cross‐sectional imaging technique in the last 30 years and hence is one of the fastest adopted advanced imaging technologies in the history of me…
View article: Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography
Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography Open
With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OC…
View article: MHz SS-OCT – from biometry to live volumetric imaging
MHz SS-OCT – from biometry to live volumetric imaging Open
View article: 3D deep learning algorithm for denoising OCTA volumes acquired at 1.68 MHz A-scan-rate
3D deep learning algorithm for denoising OCTA volumes acquired at 1.68 MHz A-scan-rate Open
View article: MHz Swept Source Optical Coherence Tomography of the Choriocapillaris
MHz Swept Source Optical Coherence Tomography of the Choriocapillaris Open
View article: Imaging the choriocapillaris with SS-OCT at MHz A-scan rates
Imaging the choriocapillaris with SS-OCT at MHz A-scan rates Open
View article: A multipurpose SS-OCT engine – from axial eye length measurements to 4D OCT
A multipurpose SS-OCT engine – from axial eye length measurements to 4D OCT Open
View article: Single shot wide field MHz swept source optical coherence tomography angiography
Single shot wide field MHz swept source optical coherence tomography angiography Open
View article: Optical coherence tomography: From technology to applications in ophthalmology
Optical coherence tomography: From technology to applications in ophthalmology Open
The relatively fast translation of optical coherence tomography (OCT) from an optical measurement technology to a standard of care in ophthalmology was driven by its ability to address clear unmet diagnostic needs. OCT's further technologi…
View article: MHz SS-OCT for imaging the choriocapillaris
MHz SS-OCT for imaging the choriocapillaris Open
View article: A clinical MHz swept-source OCT prototype for ultra-widefield imaging
A clinical MHz swept-source OCT prototype for ultra-widefield imaging Open
View article: SS-OCT Angiography of the choriocapillaris at MHz A-scan rates
SS-OCT Angiography of the choriocapillaris at MHz A-scan rates Open
View article: MHz Swept-Source OCT for clinical applications
MHz Swept-Source OCT for clinical applications Open
View article: Spiral Scanning OCT Angiography
Spiral Scanning OCT Angiography Open
View article: OCTA flow signal enhancement by reducing residual structural signal
OCTA flow signal enhancement by reducing residual structural signal Open