Tim Aeppli
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Inflammation-induced leg length discrepancy in children: from molecular mechanisms to clinical implications Open
Leg length discrepancy (LLD) refers to a condition where the lower limbs are of unequal length, which can result from various underlying causes. Inflammatory conditions in children, such as monoarticular, pauciarticular or polyarticular ju…
Genomic Effects of Biomechanical Loading in Adolescent Human Growth Plate Cartilage: A Pilot Study Open
Objective The genomic effects of biomechanical loading on human growth plate cartilage are unknown so far. To address this, we used rare human growth plate biopsies obtained from children undergoing epiphysiodesis and exposed them to preci…
The automated Greulich and Pyle: a coming-of-age for segmental methods? Open
The well-known Greulich and Pyle (GP) method of bone age assessment (BAA) relies on comparing a hand X-ray against templates of discrete maturity classes collected in an atlas. Automated methods have recently shown great success with BAA, …
View article: Standardization of Weightage Assigned to Different Segments of the Hand X-ray for Assessment of Bone Age by the Greulich–Pyle Method
Standardization of Weightage Assigned to Different Segments of the Hand X-ray for Assessment of Bone Age by the Greulich–Pyle Method Open
Introduction: Bone age (BA) assessment is important in evaluating disorders of growth and puberty; the Greulich and Pyle atlas method (GP) is most used. We aimed to determine the weightage to be attributed by raters to various segments of …
Safety and Efficacy of Bilateral Epiphysiodesis Surgery to Reduce Final Height in Extremely Tall Adolescents: A Follow-Up Study Open
Introduction: Treatment options in patients with extreme tall stature are limited. Bilateral epiphysiodesis has emerged as a possible treatment method aiming to reduce final height. However, there is still insufficient data on long-term sa…
SAT190 The Effect Of Mechanical Loading On Bone Growth Ex Vivo Open
Disclosure: T. Aeppli: None. Z. Zhang: None. F. Zaman: None. L.S. Savendahl: None. Background: Bone growth is a multi-step process that involves proliferation and differentiation of chondrocytes within the growth plate. Apart from local re…
Micromechanical Loading Studies in Ex Vivo Cultured Embryonic Rat Bones Enabled by a Newly Developed Portable Loading Device Open
Mechanical loading has been described as having the potential to affect bone growth. In order to experimentally study the potential clinical applications of mechanical loading as a novel treatment to locally modulate bone growth, there is …
Standardization of weightage assigned to different segments of the hand X-ray for assessment of bone age by the Greulich Pyle method Open
Objectives Bone age (BA) assessment is important in evaluating disorders of growth and puberty; the Greulich and Pyle atlas method (GP) is most used. We aimed to determine the weightage to be attributed by raters to various segments of the…
View article: Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation
Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation Open
We recently demonstrated that removal of one kidney (uninephrectomy; UniNx) in mice reduced high fat-diet (HFD)-induced adipose tissue inflammation thereby improving adipose tissue and hepatic insulin sensitivity. Of note, circulating cyst…
View article: Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation
Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation Open
We recently demonstrated that removal of one kidney (uninephrectomy; UniNx) in mice reduced high fat-diet (HFD)-induced adipose tissue inflammation thereby improving adipose tissue and hepatic insulin sensitivity. Of note, circulating cyst…
View article: Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation
Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation Open
We recently demonstrated that removal of one kidney (uninephrectomy [UniNx]) in mice reduced high-fat diet (HFD)-induced adipose tissue inflammation, thereby improving adipose tissue and hepatic insulin sensitivity. Of note, circulating cy…
Future glycemic control of children diagnosed with type 1 diabetes mellitus at toddler and preschool/school age Open
Background The main objective of this study was to compare future glycemic control in children diagnosed with type 1 diabetes mellitus (T1DM) at toddler age and preschool/school age. In addition, we aimed to examine risk factors known to b…