Thomas Bauer
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View article: Emphysema at Baseline Low-Dose CT Lung Cancer Screening Predicts Death from Chronic Obstructive Pulmonary Disease and Cardiovascular Disease Up to 25 Years Later
Emphysema at Baseline Low-Dose CT Lung Cancer Screening Predicts Death from Chronic Obstructive Pulmonary Disease and Cardiovascular Disease Up to 25 Years Later Open
Emphysema identified at baseline low-dose CT in a lung cancer screening program was predictive of all-cause, chronic obstructive pulmonary disease, and cardiovascular disease mortality 25 years later in 9047 asymptomatic adults with a smok…
View article: Beyond the abdomen: an unexpected finding of ectopic pancreas in a mediastinal mass
Beyond the abdomen: an unexpected finding of ectopic pancreas in a mediastinal mass Open
Ectopic pancreas (EP) is a rare congenital anomaly defined as pancreatic tissue lacking anatomical or vascular continuity with the pancreas. Although it occurs in 0.25%–2% of the population, mediastinal EP is exceedingly rare, with fewer t…
View article: Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl
Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl Open
Introduction On the outermost edge of the body a dense network of dendritic cells (DCs), the so-called Langerhans cells (LCs), represents the first immune barrier. The establishment and maintenance of this epidermal network is dependent on…
View article: JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia
JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia Open
The hair follicle stem cell niche is an immune-privileged microenvironment, characterized by reduced antigen presentation, thus shielding against permanent immune-mediated tissue damage. In this study, we demonstrated the protective role o…
View article: Recurrence of Non–Small Cell Lung Cancer With Visceral Pleural Invasion
Recurrence of Non–Small Cell Lung Cancer With Visceral Pleural Invasion Open
Importance The randomized clinical trial Cancer and Leukemia Group B (CALGB) 140503 showed that for patients with clinically staged T1N0 non–small cell lung cancer (NSCLC; ≤2 cm), sublobar resections were associated with similar oncologica…
View article: Non-invasive detection of orthotopic human lung tumors by microRNA expression profiling of mouse exhaled breath condensates and exhaled extracellular vesicles
Non-invasive detection of orthotopic human lung tumors by microRNA expression profiling of mouse exhaled breath condensates and exhaled extracellular vesicles Open
Aim: The lung is the second most frequent site of metastatic dissemination. Early detection is key to improving survival. Given that the lung interfaces with the external environment, the collection of exhaled breath condensate (EBC) provi…
View article: Radiologic Features of Nodules Attached to the Mediastinal or Diaphragmatic Pleura at Low-Dose CT for Lung Cancer Screening
Radiologic Features of Nodules Attached to the Mediastinal or Diaphragmatic Pleura at Low-Dose CT for Lung Cancer Screening Open
Background Pulmonary noncalcified nodules (NCNs) attached to the fissural or costal pleura with smooth margins and triangular or lentiform, oval, or semicircular (LOS) shapes at low-dose CT are recommended for annual follow-up instead of i…
View article: Quality-of-life impact of diaphragm plication in patients with diaphragmatic paralysis: A retrospective study
Quality-of-life impact of diaphragm plication in patients with diaphragmatic paralysis: A retrospective study Open
OBJECTIVES: While the overall incidence and prevalence of diaphragmatic paralysis are unknown due to a wide variety of underlying causes, symptomatic patients experience a marked decline in their quality of life. The goal of this study was…
View article: A 20-year Follow-up of the International Early Lung Cancer Action Program (I-ELCAP)
A 20-year Follow-up of the International Early Lung Cancer Action Program (I-ELCAP) Open
Background The low-dose CT (≤3 mGy) screening report of 1000 Early Lung Cancer Action Program (ELCAP) participants in 1999 led to the International ELCAP (I-ELCAP) collaboration, which enrolled 31 567 participants in annual low-dose CT scr…
View article: Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege Open
The hair follicle stem cell niche is an immune-privileged microenvironment, characterised by suppressed antigen presentation, thus shielding against permanent immune-mediated tissue damage. In this study, we demonstrate the protective role…
View article: Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer
Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer Open
In patients with peripheral NSCLC with a tumor size of 2 cm or less and pathologically confirmed node-negative disease in the hilar and mediastinal lymph nodes, sublobar resection was not inferior to lobectomy with respect to disease-free …
View article: Contralateral diaphragmatic injury sustained from transhumeral amputation: an unusual case and brief literature review
Contralateral diaphragmatic injury sustained from transhumeral amputation: an unusual case and brief literature review Open
Right-sided diaphragmatic injury is an uncommon sequelae from blunt trauma and may be associated with other severe thoracoabdominal injuries. This injury can be easily missed on initial assessment and a high index of suspicion and clinical…
View article: A clinical nomogram for predicting tumor regression grade in esophageal squamous-cell carcinoma treated with immune neoadjuvant immunotherapy
A clinical nomogram for predicting tumor regression grade in esophageal squamous-cell carcinoma treated with immune neoadjuvant immunotherapy Open
Our prediction model can predict the likelihood of TRG in patients with esophageal squamous cell cancer after immunotherapy combined with neoadjuvant chemotherapy. Using this prediction model, we plan to conduct a subsequent neoadjuvant ra…
View article: Ex-Vivo Skin Explant Culture Is a Model for TSLP-Mediated Skin Barrier Immunity
Ex-Vivo Skin Explant Culture Is a Model for TSLP-Mediated Skin Barrier Immunity Open
The skin is the outermost barrier protecting the body from pathogenic invasion and environmental insults. Its breakdown initiates the start of skin inflammation. The epidermal growth factor (EGFR) on keratinocytes protects this barrier, an…
View article: Development of a novel miR-3648-related gene signature as a prognostic biomarker in esophageal adenocarcinoma
Development of a novel miR-3648-related gene signature as a prognostic biomarker in esophageal adenocarcinoma Open
MiR-3648 may play a critical role in EA pathogenesis. The novel 4-gene signature may serve as a prognostic tool to manage patients with EA.