Tim Brecklinghaus
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View article: Adjustment for day-to-day variability in the estimation of effective concentrations for the assessment of mixture toxicity
Adjustment for day-to-day variability in the estimation of effective concentrations for the assessment of mixture toxicity Open
Humans are exposed to a multitude of substances at the same time; thus, toxicity assessment for mixtures of several substances and not only for the individual substances is critical. An important challenge in testing the mixture effects of…
View article: Improved identification of human hepatotoxic potential by summary variables of gene expression
Improved identification of human hepatotoxic potential by summary variables of gene expression Open
Prediction of hepatotoxicity in humans remains an unresolved challenge. Recently, an in vitro/in silico method was established to predict blood concentrations of test compounds with an increased risk of causing human hepatotoxicity. In the…
View article: Design of optimal concentrations for in vitro cytotoxicity experiments
Design of optimal concentrations for in vitro cytotoxicity experiments Open
Concentration-dependent cytotoxicity experiments are frequently used in toxicology. Although it has been reported that an adequate choice of concentrations improves the quality of the statistical inference substantially, a recent literatur…
View article: Classification of hepatotoxicity of compounds based on cytotoxicity assays is improved by additional interpretable summaries of high-dimensional gene expression data
Classification of hepatotoxicity of compounds based on cytotoxicity assays is improved by additional interpretable summaries of high-dimensional gene expression data Open
Established cytotoxicity assays are commonly used for assessing the hepatotoxic risk of a compound. The addition of gene expression measurements from high-dimensional RNAseq experiments offers the potential for improved classification. How…
View article: Guidance for statistical design and analysis of toxicological dose–response experiments, based on a comprehensive literature review
Guidance for statistical design and analysis of toxicological dose–response experiments, based on a comprehensive literature review Open
View article: In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay Open
View article: Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity Open
View article: The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds Open
View article: Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes Open
View article: Comparing in vitro human liver models to in vivo human liver using RNA-Seq
Comparing in vitro human liver models to in vivo human liver using RNA-Seq Open
View article: Handling deviating control values in concentration-response curves
Handling deviating control values in concentration-response curves Open
In cell biology, pharmacology and toxicology dose-response and concentration-response curves are frequently fitted to data with statistical methods. Such fits are used to derive quantitative measures (e.g. EC $$_{20}$$ values) describin…
View article: Roadmap for the development of alternative test methods
Roadmap for the development of alternative test methods Open
View article: Role of autophagy in drug induced liver injury
Role of autophagy in drug induced liver injury Open
Pyrrolizidine alkaloids (PA) exert their toxic effects only after bioactivation. Although their toxicity has already been studied and metabolic pathways including important metabolites were described, the quantification of the latter revea…
View article: Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle
Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle Open
View article: The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods Open
View article: Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations Open
View article: Highlight report: Import of fatty acids by metastasizing tumor cells
Highlight report: Import of fatty acids by metastasizing tumor cells Open