T. Campbell
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View article: Profiling antibody epitopes induced by mRNA-1273 vaccination and boosters
Profiling antibody epitopes induced by mRNA-1273 vaccination and boosters Open
Background Characterizing the antibody epitope profiles of messenger RNA (mRNA)-based vaccines against SARS-CoV-2 can aid in elucidating the mechanisms underlying the antibody-mediated immune responses elicited by these vaccines. Methods T…
View article: Methods of hydrolyzing pretreated densified biomass particulates and systems related thereto
Methods of hydrolyzing pretreated densified biomass particulates and systems related thereto Open
A method is provided in which pretreated and densified cellulosic biomass particulates can be hydrolyzed at a high solids loading rate as compared with the solids loading rate of loose hydrolysable cellulosic biomass fibers. The resulting …
View article: 130 Precise spatial multiplexing for immune cell profiling of the tumor microenvironment with ChipCytometry
130 Precise spatial multiplexing for immune cell profiling of the tumor microenvironment with ChipCytometry Open
Background Understanding the spatial distribution of key immune cell populations is critical in advancing our understanding of cancer to inform the development of novel therapeutics. Historically, the spatial analysis of the tumor microenv…
View article: Exact Shapley values for local and model-true explanations of decision tree ensembles
Exact Shapley values for local and model-true explanations of decision tree ensembles Open
Additive feature explanations using Shapley values have become popular for providing transparency into the relative importance of each feature to an individual prediction of a machine learning model. While Shapley values provide a unique a…
View article: Exact Shapley Values for Local and Model-True Explanations of Decision Tree Ensembles
Exact Shapley Values for Local and Model-True Explanations of Decision Tree Ensembles Open
Additive feature explanations using Shapley values have become popular for providing transparency into the relative importance of each feature to an individual prediction of a machine learning model. While Shapley values provide a unique a…
View article: 40 Precise spatial multiplexing for immune profiling in non-small cell lung cancer FFPE samples with ChipCytometry
40 Precise spatial multiplexing for immune profiling in non-small cell lung cancer FFPE samples with ChipCytometry Open
Background Emergent data indicate that highly multiplexed spatial biomarker analysis has the potential to advance precision medicine in immuno-oncology and inform the discovery of novel biomarkers. Methods Here we present the analysis of c…
View article: 831 Exact Shapley values for explaining complex machine learning based molecular tests of checkpoint inhibitors: potential utility for patients, physicians, and translational research
831 Exact Shapley values for explaining complex machine learning based molecular tests of checkpoint inhibitors: potential utility for patients, physicians, and translational research Open
Background Modern machine learning (ML) models based on highly multivariate attribute sets (e.g. unbiased -omics data) can be very successful at generating clinically useful predictions, but at the price of less transparency in how individ…
View article: 26 Validation of the Primary Immune Response (PIR) test in advanced non-small cell lung cancer (NSCLC): blinded retrospective analyses from the POPLAR and OAK trials
26 Validation of the Primary Immune Response (PIR) test in advanced non-small cell lung cancer (NSCLC): blinded retrospective analyses from the POPLAR and OAK trials Open
Background Biomarkers of immune checkpoint inhibitor (ICI) efficacy can be used for patient selection. PD-L1 expression in tumor tissue is used to determine eligibility for combination or monotherapy in 1st line NSCLC. 1, 2 The liquid-biop…
View article: 28 Predictions of outcomes and benefit of immune checkpoint inhibitor treatment in NSCLC require information on both tumor and host biology
28 Predictions of outcomes and benefit of immune checkpoint inhibitor treatment in NSCLC require information on both tumor and host biology Open
Background Immunotherapy has become a key element in the arsenal of treatments for advanced non-small cell lung cancer (NSCLC). The anti-PD-L1 Response Test (ART), based on mass spectrometry of pretreatment serum, captures the effect of ho…
View article: Predicting prognosis in COVID-19 patients using machine learning and readily available clinical data
Predicting prognosis in COVID-19 patients using machine learning and readily available clinical data Open
Risk of severe outcomes for patients hospitalized with COVID-19 infection can be assessed using machine learning-based models based on attributes routinely collected at hospital admission.
View article: Predicting Prognosis in COVID-19 Patients using Machine Learning and Readily Available Clinical Data
Predicting Prognosis in COVID-19 Patients using Machine Learning and Readily Available Clinical Data Open
Rationale Prognostic tools for aiding in the treatment of hospitalized COVID-19 patients could help improve outcome by identifying patients at higher or lower risk of severe disease. Objectives The study objective was to develop models to …
View article: First measurement of the charged current <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mover accent="true"><mml:mi>ν</mml:mi><mml:mo stretchy="false">¯</mml:mo></mml:mover><mml:mi>μ</mml:mi></mml:msub></mml:math> double differential cross section on a water target without pions in the final state
First measurement of the charged current double differential cross section on a water target without pions in the final state Open
© 2020 authors. Published by the American Physical Society. This paper reports the first differential measurement of the charged-current ν¯μ interaction cross section on water with no pions in the final state. The unfolded flux-averaged me…
View article: Simultaneous measurement of the muon neutrino charged-current cross section on oxygen and carbon without pions in the final state at T2K
Simultaneous measurement of the muon neutrino charged-current cross section on oxygen and carbon without pions in the final state at T2K Open
This paper reports the first simultaneous measurement of the double differential muon neutrino charged-current cross section on oxygen and carbon without pions in the final state as a function of the outgoing muon kinematics, made at the N…
View article: First combined measurement of the muon neutrino and antineutrino charged-current cross section without pions in the final state at T2K
First combined measurement of the muon neutrino and antineutrino charged-current cross section without pions in the final state at T2K Open
This paper presents the first combined measurement of the double-differential muon neutrino and antineutrino charged-current cross sections with no pions in the final state on hydrocarbon at the off-axis near detector of the T2K experiment…
View article: Search for Electron Antineutrino Appearance in a Long-Baseline Muon Antineutrino Beam
Search for Electron Antineutrino Appearance in a Long-Baseline Muon Antineutrino Beam Open
Electron antineutrino appearance is measured by the T2K experiment in an accelerator-produced antineutrino beam, using additional neutrino beam operation to constrain parameters of the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) mixing matrix. …
View article: Measurement of the muon neutrino charged-current single <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msup><mml:mi>π</mml:mi><mml:mo>+</mml:mo></mml:msup></mml:math> production on hydrocarbon using the T2K off-axis near detector ND280
Measurement of the muon neutrino charged-current single production on hydrocarbon using the T2K off-axis near detector ND280 Open
We report the measurements of the single and double differential cross section of muon neutrino charged-current interactions on carbon with a single positively charged pion in the final state at the T2K off-axis near detector using 5.56×10…
View article: Measurement of the charged-current electron (anti-)neutrino inclusive cross-sections at the T2K off-axis near detector ND280
Measurement of the charged-current electron (anti-)neutrino inclusive cross-sections at the T2K off-axis near detector ND280 Open
The electron (anti-)neutrino component of the T2K neutrino beam constitutes the largest background in the measurement of electron (anti-)neutrino appearance at the far detector. The electron neutrino scattering is measured directly with th…
View article: Constraint on the matter–antimatter symmetry-violating phase in neutrino oscillations
Constraint on the matter–antimatter symmetry-violating phase in neutrino oscillations Open
The charge-conjugation and parity-reversal (CP) symmetry of fundamental particles is a symmetry between matter and antimatter. Violation of this CP symmetry was first observed in 1964$^1$, and CP violation in the weak interactions of quark…
View article: Measurement of neutrino and antineutrino neutral-current quasielasticlike interactions on oxygen by detecting nuclear deexcitation <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>γ</mml:mi></mml:math> rays
Measurement of neutrino and antineutrino neutral-current quasielasticlike interactions on oxygen by detecting nuclear deexcitation rays Open
Neutrino- and antineutrino-oxygen neutral-current quasielasticlike interactions are measured at Super-Kamiokande using nuclear deexcitation γ rays to identify signal-like interactions in data from a 14.94(16.35)×1020 protons-on-target expo…
View article: Search for heavy neutrinos with the T2K near detector ND280
Search for heavy neutrinos with the T2K near detector ND280 Open
This paper reports on the search for heavy neutrinos with masses in the range 140<MN<493 MeV/c2 using the off-axis near detector ND280 of the T2K experiment. These particles can be produced from kaon decays in the standard neutrino …
View article: Measurement of the muon neutrino charged-current cross sections on water, hydrocarbon and iron, and their ratios, with the T2K on-axis detectors
Measurement of the muon neutrino charged-current cross sections on water, hydrocarbon and iron, and their ratios, with the T2K on-axis detectors Open
We report a measurement of the flux-integrated charged-current cross sections on water, hydrocarbon, and iron in the T2K on-axis neutrino beam with a mean neutrino energy of 1.5 GeV. The measured cross sections on water, hydrocarbon, and i…
View article: J-PARC Neutrino Beamline Upgrade Technical Design Report
J-PARC Neutrino Beamline Upgrade Technical Design Report Open
In this document, technical details of the upgrade plan of the J-PARC neutrino beamline for the extension of the T2K experiment are described. T2K has proposed to accumulate data corresponding to $2\times{}10^{22}$ protons-on-target in the…
View article: Search for neutral-current induced single photon production at the ND280 near detector in T2K
Search for neutral-current induced single photon production at the ND280 near detector in T2K Open
Neutrino neutral-current (NC) induced single photon production is a sub-leading order process for accelerator-based neutrino beam experiments including T2K. It is, however, an important process to understand because it is a background for …
View article: Search for light sterile neutrinos with the T2K far detector Super-Kamiokande at a baseline of 295 km
Search for light sterile neutrinos with the T2K far detector Super-Kamiokande at a baseline of 295 km Open
Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
View article: T2K ND280 Upgrade -- Technical Design Report
T2K ND280 Upgrade -- Technical Design Report Open
In this document, we present the Technical Design Report of the Upgrade of the T2K Near Detector ND280. The goal of this upgrade is to improve the Near Detector performance to measure the neutrino interaction rate and to constrain the neut…
View article: Characterization of nuclear effects in muon-neutrino scattering on hydrocarbon with a measurement of final-state kinematics and correlations in charged-current pionless interactions at T2K
Characterization of nuclear effects in muon-neutrino scattering on hydrocarbon with a measurement of final-state kinematics and correlations in charged-current pionless interactions at T2K Open
This paper reports measurements of final-state proton multiplicity, muon and proton kinematics, and their correlations in charged-current pionless neutrino interactions, measured by the T2K ND280 near detector in its plastic scintillator (…
View article: Sensitivity of the T2K accelerator-based neutrino experiment with an Extended run to $20\times10^{21}$ POT
Sensitivity of the T2K accelerator-based neutrino experiment with an Extended run to $20\times10^{21}$ POT Open
Recent measurements at the T2K experiment indicate that CP violation in neutrino mixing may be observed in the future by long-baseline neutrino oscillation experiments. We explore the physics program of an extension to the currently approv…