Tim Ebert
YOU?
Author Swipe
View article: SKA2 enhances stress-related glucocorticoid receptor signaling through FKBP4–FKBP5 interactions in neurons
SKA2 enhances stress-related glucocorticoid receptor signaling through FKBP4–FKBP5 interactions in neurons Open
Genes involved in regulating the hypothalamic–pituitary–adrenal (HPA) axis, including the glucocorticoid receptor (GR), are linked to various stress-related psychopathologies including bipolar disorder as well as other mood and trauma-rela…
View article: Spermidine alleviates depression via control of the stress response
Spermidine alleviates depression via control of the stress response Open
Depression is a stress-associated disorder, and it represents a major global health issue. Its pathophysiology is complex and remains insufficiently understood, with current medications often showing limited efficacy and undesirable side e…
View article: SKArred 2 death: neuroinflammatory breakdown of the hippocampus
SKArred 2 death: neuroinflammatory breakdown of the hippocampus Open
A multitude of cellular responses to intrinsic and extrinsic signals converge on macroautophagy/autophagy, a conserved catabolic process that degrades cytoplasmic constituents and organelles in the lysosome, particularly during starvation …
View article: SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration Open
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic mo…
View article: From bungee jumps to depression slumps: an investigation into the interplay between stress and autophagy
From bungee jumps to depression slumps: an investigation into the interplay between stress and autophagy Open
View article: ADHD Prevalence among Outpatients with Severe Opioid Use Disorder on Daily Intravenous Diamorphine and/or Oral Opioid Maintenance Treatment
ADHD Prevalence among Outpatients with Severe Opioid Use Disorder on Daily Intravenous Diamorphine and/or Oral Opioid Maintenance Treatment Open
(1) Background: Attention deficit hyperactivity disorder (ADHD) is a common comorbid condition in opioid use disorder (OUD) and is associated with a more severe course of substance use. Patients with severe OUD who have not responded to or…
View article: Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning
Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning Open
View article: Myo-Inositol Levels in the Dorsal Hippocampus Serve as Glial Prognostic Marker of Mild Cognitive Impairment in Mice
Myo-Inositol Levels in the Dorsal Hippocampus Serve as Glial Prognostic Marker of Mild Cognitive Impairment in Mice Open
Dementia is a devastating age-related disorder. Its therapy would largely benefit from the identification of susceptible subjects at early, prodromal stages of the disease. To search for such prognostic markers of cognitive impairment, we …
View article: Analysis of the cerebellar molecular stress response led to first evidence of a role for FKBP51 in brain FKBP52 expression in mice and humans
Analysis of the cerebellar molecular stress response led to first evidence of a role for FKBP51 in brain FKBP52 expression in mice and humans Open
View article: Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion Open
View article: SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals Open
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we sh…
View article: Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5
Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5 Open
Responding to different dynamic levels of stress is critical for mammalian survival. Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to underlie hypothalamic-pituitary-adrenal (HPA) axis…
View article: Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice
Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice Open
View article: Hippo-Released WWC1 Primes Ampa Receptor Regulatory Complexes for Hippocampal Learning
Hippo-Released WWC1 Primes Ampa Receptor Regulatory Complexes for Hippocampal Learning Open