Tim Gruber
YOU?
Author Swipe
View article: TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states Open
View article: HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice
HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice Open
View article: Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes
Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes Open
Aim To assess oxytocin's acute glucoregulatory impact in men with type 2 diabetes in the context of our previous findings that oxytocin improves β‐cell responsivity in healthy men. Methods In a double‐blind, crossover comparison, intranasa…
View article: Neuroendocrine gut–brain signaling in obesity
Neuroendocrine gut–brain signaling in obesity Open
View article: Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity
Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity Open
View article: High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling
High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling Open
View article: Epigenetic dosage identifies two major and functionally distinct β cell subtypes
Epigenetic dosage identifies two major and functionally distinct β cell subtypes Open
View article: The dietary sweetener sucralose is a negative modulator of T cell-mediated responses
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Open
View article: Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1
Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1 Open
Until menopause, women have a lower propensity to develop metabolic diseases than men, suggestive of a protective role for sex hormones. Although a functional synergy between central actions of estrogens and leptin has been demonstrated to…
View article: An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats
An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats Open
The hypothalamic neuropeptide oxytocin (OT) exerts prominent analgesic effects via central and peripheral action. However, the precise analgesic pathways recruited by OT are largely elusive. Here we discovered a subset of OT neurons whose …
View article: Identification of two β-cell subtypes by 7 independent criteria
Identification of two β-cell subtypes by 7 independent criteria Open
Summary Despite the recent explosion in surveys of cell-type heterogeneity, the mechanisms that specify and stabilize highly related cell subtypes remain poorly understood. Here, focusing initially on exploring quantitative histone mark he…
View article: Correction to: Control of Systemic Metabolism by Astrocytes in the Brain
Correction to: Control of Systemic Metabolism by Astrocytes in the Brain Open
View article: Analysis of the hypothalamic oxytocin system and oxytocin receptor‐expressing astrocytes in a mouse model of <scp>Prader–Willi</scp> syndrome
Analysis of the hypothalamic oxytocin system and oxytocin receptor‐expressing astrocytes in a mouse model of <span>Prader–Willi</span> syndrome Open
Prader–Willi syndrome (PWS) is a neurodevelopmental disorder characterized by hyperphagia, obesity, developmental delay and intellectual disability. Studies suggest dysfunctional signaling of the neuropeptide oxytocin as one of the key mec…
View article: Independent phenotypic plasticity axes define distinct obesity sub-types
Independent phenotypic plasticity axes define distinct obesity sub-types Open
Studies in genetically ‘identical’ individuals indicate that as much as 50% of complex trait variation cannot be traced to genetics or to the environment. The mechanisms that generate this ‘unexplained’ phenotypic variation (UPV) remain la…
View article: Coupling of oxytocin and cholecystokinin pathways in the hypothalamus is required for gut-to-brain homeostatic feeding control
Coupling of oxytocin and cholecystokinin pathways in the hypothalamus is required for gut-to-brain homeostatic feeding control Open
Summary Oxytocin-expressing paraventricular hypothalamic neurons (PVN OT neurons) integrate afferent signals from the gut including cholecystokinin (CCK) to adjust whole-body energy homeostasis. However, the molecular underpinnings by whic…
View article: Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner
Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner Open
Hypothalamic astrocytes are particularly affected by energy‐dense food consumption. How the anatomical location of these glial cells and their spatial molecular distribution in the arcuate nucleus of the hypothalamus (ARC) determine the ce…
View article: Global, neuronal, and beta-cell specific deletion of insulin inhibitory receptor (incep-tor) improves glucose homeostasis in diet-induced obese mice
Global, neuronal, and beta-cell specific deletion of insulin inhibitory receptor (incep-tor) improves glucose homeostasis in diet-induced obese mice Open
Our data support the hypothesis that inhibition of inceptor to sensitize INSR/IGF1R action may be a promising pharmacological target in the context of diet-induced impairments of glucose homeostasis, with the potential to avoid 𝛽-cell fail…
View article: Hypercaloric diet triggers transient molecular rearrangements of astrocytes selectively in the arcuate nucleus
Hypercaloric diet triggers transient molecular rearrangements of astrocytes selectively in the arcuate nucleus Open
SUMMARY Hypothalamic astrocytes are particularly affected by energy-dense food consumption. How the anatomical location of these glial cells and their spatial molecular distribution in the arcuate nucleus of the hypothalamus (ARC) determin…
View article: Correction to: The Neuroanatomical Organization of Hypothalamic Feeding Circuits
Correction to: The Neuroanatomical Organization of Hypothalamic Feeding Circuits Open
View article: Coupling of Oxytocin and Cholecystokinin Pathways in the Hypothalamus is Required for Gut-to-Brain Homeostatic Feeding Control
Coupling of Oxytocin and Cholecystokinin Pathways in the Hypothalamus is Required for Gut-to-Brain Homeostatic Feeding Control Open
View article: Author Correction: Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
Author Correction: Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH Open
View article: Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension Open
View article: Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH Open
View article: Insulin action on astrocytes: From energy homeostasis to behaviour
Insulin action on astrocytes: From energy homeostasis to behaviour Open
Astrocytes are specialised glial cells that integrate distinct inputs arising from neurones, other glial cells and the microcirculation to regulate diverse aspects of brain function. A growing body of emerging evidence supports that astroc…
View article: Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis Open
View article: Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis Open
Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a key feature of adipose dysfunction and inflammation. However, very little is known about the direct effects of impaire…
View article: Functional identity of hypothalamic melanocortin neurons depends on Tbx3
Functional identity of hypothalamic melanocortin neurons depends on Tbx3 Open
View article: Publisher Correction: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
Publisher Correction: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes Open
View article: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes Open
View article: Chronic d-serine supplementation impairs insulin secretion
Chronic d-serine supplementation impairs insulin secretion Open