Tim Holzinger
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View article: Differential functionality of fluoropyrimidine nucleosides for safe cancer therapy
Differential functionality of fluoropyrimidine nucleosides for safe cancer therapy Open
Chemotherapies are standard care for most cancer types. Pyrimidine analogs including 5-fluorouracil, cytosine arabinoside, 5-azacytidine, and gemcitabine are effective drugs that are utilized as part of a number of anticancer regimens. How…
View article: RNA with chemotherapeutic base analogues as a dual-functional anti-cancer drug
RNA with chemotherapeutic base analogues as a dual-functional anti-cancer drug Open
Nanoparticles of different sizes formulated with unmodified RNA and Protamine differentially engage Toll-like Receptors (TLRs) and activate innate immune responses in vitro. Here, we report that similar differential immunostimulation that …