Tim H.‐M. Huang
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View article: Supplementary Data from PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer
Supplementary Data from PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer Open
Supplementary information
View article: Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation
Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation Open
Understanding why isogenic cancer cells respond differently to equivalent oncogenic stimuli is vital for optimizing anticancer therapies. Emerging evidence suggests that pre-existing differences in cell state may modulate signaling respons…
View article: Identification of a 5-gene signature panel for the prediction of prostate cancer progression
Identification of a 5-gene signature panel for the prediction of prostate cancer progression Open
Background Despite nearly 100% 5-year survival for localised prostate cancer, the survival rate for metastatic prostate cancer significantly declines to 32%. Thus, it is crucial to identify molecular indicators that reflect the progression…
View article: Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination
Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination Open
View article: Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions
Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions Open
View article: AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages
AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages Open
Tumor-associated macrophages (TAMs) are integral to the development of complex tumor microenvironments (TMEs) and can execute disparate cellular programs in response to extracellular cues. However, upstream signaling processes underpinning…
View article: Supplementary Figure 2 from Growth Inhibition of Ovarian Tumor–Initiating Cells by Niclosamide
Supplementary Figure 2 from Growth Inhibition of Ovarian Tumor–Initiating Cells by Niclosamide Open
PDF file, 2736KB, Niclosamide treatment (10mg/kg/daily) was given intraperitoneally every week one day after OTICs inoculation in NOD/SCID mice. Furthermore, Body weights remained constant during niclosamide treatment demonstrating a lack …
View article: Data from A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis
Data from A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis Open
Familial adenomatous polyposis (FAP) is characterized by the early onset of colonic polyposis and a high risk for colorectal cancer. FAP is treated by colectomy followed by lifelong removal of rectal polyps. This study determined whether b…
View article: Supplementary Figure Legends from Promoter Methylation Modulates Indoleamine 2,3-Dioxygenase 1 Induction by Activated T Cells in Human Breast Cancers
Supplementary Figure Legends from Promoter Methylation Modulates Indoleamine 2,3-Dioxygenase 1 Induction by Activated T Cells in Human Breast Cancers Open
Figure Legends for Supplementary Figures 1-6
View article: Data from Growth Inhibition of Ovarian Tumor–Initiating Cells by Niclosamide
Data from Growth Inhibition of Ovarian Tumor–Initiating Cells by Niclosamide Open
A recent hypothesis for cancer chemoresistance posits that cytotoxic survival of a subpopulation of tumor progenitors drives the propagation of recurrent disease, underscoring the need for new therapeutics that target such primitive cells.…
View article: Supplementary Materials and Methods from A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis
Supplementary Materials and Methods from A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis Open
PDF file - 38KB
View article: Data from A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis
Data from A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis Open
Familial adenomatous polyposis (FAP) is characterized by the early onset of colonic polyposis and a high risk for colorectal cancer. FAP is treated by colectomy followed by lifelong removal of rectal polyps. This study determined whether b…
View article: Supplementary Materials and Methods from A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis
Supplementary Materials and Methods from A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis Open
PDF file - 38KB
View article: Supplemental Table S1 from EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition
Supplemental Table S1 from EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition Open
List of primer sequences
View article: Supplementary Data from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER<sup>+</sup> Breast Cancer
Supplementary Data from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER<sup>+</sup> Breast Cancer Open
Supplementary Data from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer
View article: Figure S1-S8 from Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis
Figure S1-S8 from Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis Open
This file contains eight supplementary figures depicting the experiments validated in different cell lines and cohorts, as well as the results supportive to the main text.
View article: Data from Modulation of Genetic and Epigenetic Biomarkers of Colorectal Cancer in Humans by Black Raspberries: A Phase I Pilot Study
Data from Modulation of Genetic and Epigenetic Biomarkers of Colorectal Cancer in Humans by Black Raspberries: A Phase I Pilot Study Open
Purpose: This study evaluated the effects of black raspberries (BRBs) on biomarkers of tumor development in the human colon and rectum including methylation of relevant tumor suppressor genes, cell proliferation, apoptosis, angiogen…
View article: Supplementary text from Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis
Supplementary text from Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis Open
This file contains the supplementary information including materials and methods, primer sequences, clinicopathological characteristics of patient samples and supplemental figures legends.
View article: Data from Integrated Epigenomics Analysis Reveals a DNA Methylation Panel for Endometrial Cancer Detection Using Cervical Scrapings
Data from Integrated Epigenomics Analysis Reveals a DNA Methylation Panel for Endometrial Cancer Detection Using Cervical Scrapings Open
Purpose: Endometrial cancer is a common gynecologic cancer whose incidence is increasing annually worldwide. Current methods to detect endometrial cancer are unreliable and biomarkers are unsatisfactory for screening. Cervical scrap…
View article: Supplemental Table S1 from EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition
Supplemental Table S1 from EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition Open
List of primer sequences
View article: Data from Differential Methylation Hybridization Array of Endometrial Cancers Reveals Two Novel Cancer-Specific Methylation Markers
Data from Differential Methylation Hybridization Array of Endometrial Cancers Reveals Two Novel Cancer-Specific Methylation Markers Open
Purpose: To identify novel endometrial cancer-specific methylation markers and to determine their association with clinicopathologic variables and survival outcomes.Experimental Design: Differential methylation hybridization …
View article: Supplementary Table S1 from Differential Methylation Hybridization Array of Endometrial Cancers Reveals Two Novel Cancer-Specific Methylation Markers
Supplementary Table S1 from Differential Methylation Hybridization Array of Endometrial Cancers Reveals Two Novel Cancer-Specific Methylation Markers Open
Supplementary Table S1 from Differential Methylation Hybridization Array of Endometrial Cancers Reveals Two Novel Cancer-Specific Methylation Markers
View article: Supplementary Table from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER<sup>+</sup> Breast Cancer
Supplementary Table from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER<sup>+</sup> Breast Cancer Open
Supplementary Table from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer
View article: Supplementary Figure from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER<sup>+</sup> Breast Cancer
Supplementary Figure from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER<sup>+</sup> Breast Cancer Open
Supplementary Figure from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer
View article: Supplementary Figure from EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition
Supplementary Figure from EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition Open
Supplementary Figure S1 Expression of EpCAM, LEF1 in human endometrial cancer patients, cancer cell lines and mouse endometrial tissues. Supplementary Figure S2 Quantification of EpEX immunofluorescence staining and EGFR expression in endo…
View article: Data from Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis
Data from Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis Open
Resistance to cancer treatment can be driven by epigenetic reprogramming of specific transcriptomes in favor of the refractory phenotypes. Here we discover that tamoxifen resistance in breast cancer is driven by a regulatory axis consistin…
View article: Supplementary Table S2 from Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle–Related Transcription and Attenuated Androgen Response
Supplementary Table S2 from Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle–Related Transcription and Attenuated Androgen Response Open
Supplementary Table S2: qPCR primer for subcluster E genes
View article: Figure S1-S8 from Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis
Figure S1-S8 from Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis Open
This file contains eight supplementary figures depicting the experiments validated in different cell lines and cohorts, as well as the results supportive to the main text.
View article: Supplementary Data from Modulation of Genetic and Epigenetic Biomarkers of Colorectal Cancer in Humans by Black Raspberries: A Phase I Pilot Study
Supplementary Data from Modulation of Genetic and Epigenetic Biomarkers of Colorectal Cancer in Humans by Black Raspberries: A Phase I Pilot Study Open
Supplementary Figure S1; Supplementary Tables S1-S4.
View article: Supplementary Data from PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer
Supplementary Data from PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer Open
Supplementary information