Tim Hurley
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View article: Altered sleep and inflammation are related to outcomes in neonatal encephalopathy
Altered sleep and inflammation are related to outcomes in neonatal encephalopathy Open
Aim Immune dysregulation and delayed onset of sleep wake cycling (SWC) are associated with worse outcome in neonatal encephalopathy (NE), however the association between sleep and immune dysfunction in NE remains unclear. Aimed to evaluate…
View article: Neonatal encephalopathy: a systematic review of reported treatment outcomes
Neonatal encephalopathy: a systematic review of reported treatment outcomes Open
Background Neonatal encephalopathy (NE) is a multi-organ condition potentially leading to death or long-term neurodisability. Therapeutic hypothermia is the standard treatment for NE; however, long-term impairments remain common. Studies o…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology Open
BACKGROUND: Preterm birth is associated with significant risks for long-term impairments in brain structure and cognitive functions (1). At the microscopic level, the transient inflammatory and hypoxic-ischemic events occurring during prem…
View article: Consensus definition and diagnostic criteria for neonatal encephalopathy—study protocol for a real-time modified delphi study
Consensus definition and diagnostic criteria for neonatal encephalopathy—study protocol for a real-time modified delphi study Open
Background ‘Neonatal encephalopathy’ (NE) describes a group of conditions in term infants presenting in the earliest days after birth with disturbed neurological function of cerebral origin. NE is aetiologically heterogenous; one cause is …
View article: Heliox for prevention of morbidity and mortality in ventilated newborn infants
Heliox for prevention of morbidity and mortality in ventilated newborn infants Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To determine the effect of heliox on the rates of mortality, neurodevelopmental outcome, and chronic lung disease in invasively ventilated infants.
View article: Neuroprotective therapies in the NICU in term infants: present and future
Neuroprotective therapies in the NICU in term infants: present and future Open
Outcomes of neonatal encephalopathy (NE) have improved since the widespread implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE in term and near-term infants has proven beneficial, 30–50% of infants wi…
View article: Core outcomes in neonatal encephalopathy: a qualitative study with parents
Core outcomes in neonatal encephalopathy: a qualitative study with parents Open
Objective To identify the outcomes considered important to parents or caregivers of infants diagnosed with neonatal encephalopathy, hypoxic ischaemic encephalopathy or birth asphyxia in high-income and low- to middle-income countries (LMiC…
View article: Neutrophils in COVID-19: Not Innocent Bystanders
Neutrophils in COVID-19: Not Innocent Bystanders Open
Unusually for a viral infection, the immunological phenotype of severe COVID-19 is characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil-to-lymphocyte ratio correlating with disease severity. Neutrophils…
View article: Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring
Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring Open
OBJECTIVE:We assessed the impact of early enteral feeding introduction during therapeutic hypothermia on time to reach full enteral feeding (FEF) and other feeding related outcomes in infants born at ≥35 weeks gestational age and diagnosed…
View article: Relationship Between MRI Scoring Systems and Neurodevelopmental Outcome at Two Years in Infants With Neonatal Encephalopathy
Relationship Between MRI Scoring Systems and Neurodevelopmental Outcome at Two Years in Infants With Neonatal Encephalopathy Open
Our findings confirm the predictive value of existing MRI scoring systems for cognitive and motor outcome and suggest that more detailed scoring systems have predictive value for language outcome.
View article: Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes
Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes Open
Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by ac…
View article: Carbon dioxide levels in neonates: what are safe parameters?
Carbon dioxide levels in neonates: what are safe parameters? Open
There is no consensus on the optimal pCO 2 levels in the newborn. We reviewed the effects of hypercapnia and hypocapnia and existing carbon dioxide thresholds in neonates. A systematic review was conducted in accordance with the PRISMA sta…
View article: Bisphosphonate use in children with cerebral palsy
Bisphosphonate use in children with cerebral palsy Open
Based on the available evidence, there is very low certainty evidence that bisphosphonate treatment may improve bone health in children with cerebral palsy. We could only include one study with 14 participants in the assessment of the effe…
View article: Heliox for prevention of morbidity and mortality in ventilated newborn infants
Heliox for prevention of morbidity and mortality in ventilated newborn infants Open
23 February 2021. The protocol was withdrawn because it is out of date and does not meet the current methodological standards of Cochrane.
View article: Dysregulated Monocyte and Neutrophil Functional Phenotype in Infants With Neonatal Encephalopathy Requiring Therapeutic Hypothermia
Dysregulated Monocyte and Neutrophil Functional Phenotype in Infants With Neonatal Encephalopathy Requiring Therapeutic Hypothermia Open
Neonatal encephalopathy (NE) is a significant cause of morbidity and mortality. Persistent inflammation and activation of leukocytes mediate brain injury in NE. The standard of care for NE, therapeutic hypothermia (TH), does not improve ou…
View article: COHESION: core outcomes in neonatal encephalopathy (protocol)
COHESION: core outcomes in neonatal encephalopathy (protocol) Open
Background Neonatal encephalopathy is a complex syndrome in infants that predominantly affects the brain and other organs. The leading cause is a lack of oxygen in the blood reaching the brain. Neonatal encephalopathy can result in mortali…
View article: OC61 A systematic review of serum biomarkers in neonatal encephalopathy to predict short term outcome
OC61 A systematic review of serum biomarkers in neonatal encephalopathy to predict short term outcome Open
Background Neonatal Encephalopathy (NE) describes central nervous system dysfunction from all causes and has a multifactorial aetiology. NE is difficult to diagnose, to treat and to predict outcome. Early prognostic information is importan…