Ke Tang
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View article: The NLRP3 inflammasome in depression: A narrative review from neuroinflammation to novel therapeutic approaches
The NLRP3 inflammasome in depression: A narrative review from neuroinflammation to novel therapeutic approaches Open
This review examines the role of the NLRP3 inflammasome in the pathogenesis of depression, with an emphasis on its inflammatory functions and implications for therapeutic development. Depression is a prevalent and debilitating mental disor…
The lnc-MAPKAPK5-AS1 promotes colon cancer-derived liver metastasis via modulating the tumor microenvironment: an <i>in silico</i> study and immunohistochemistry validation Open
Background: This study aimed to investigate the expression of lnc-MAPKAPK5-AS1 in colon cancer and its clinical implications for prognosis, liver metastasis, and tumor microenvironment (TME) regulation. Methods: Through integrative analysi…
Network analysis used to investigate the symptoms of cancer patients during chemotherapy: a scoping review Open
Symptom network analysis offers insights into the complex interplay of symptoms during chemotherapy, highlighting fatigue as a central symptom. Future research should focus on longitudinal studies to better understand the dynamic changes i…
The Research Progress on the Role of Adenosine A1 Receptors in Acupuncture Analgesia Mechanism Open
Acupuncture analgesia has become a key focus of acupuncture research in recent years, and the role of adenosine receptors in acupuncture-induced analgesia requires further investigation. Adenosine (ADO) is an important neurotransmitter in …
A novel prostate cancer-specific fluorescent probe based on extracellular vesicles targeting STEAP1 applied in fluorescence guided surgery Open
Radical prostatectomy with pelvic lymph node dissection is the best treatment for intermediate- to high-risk localized prostate cancer (PCa). However, conventional white light surgery has difficulties in identifying tumor boundary and micr…
Co‐Translational Deposition of <i>N</i><sup>6</sup>‐Acetyl‐<i>L</i>‐Lysine in Nascent Proteins Contributes to the Acetylome in Mammalian Cells Open
N 6 ‐acetyl‐ L ‐ lysine residue is abundant in dietary protein but little is known about its potential influences on the diet‐consumers. Herein, it is reported that Lysyl‐tRNA synthetase (KARS) mediates co‐translational deposition of diet‐…
View article: Sustained AhR activity programs memory fate of early effector CD8 <sup>+</sup> T cells
Sustained AhR activity programs memory fate of early effector CD8 <sup>+</sup> T cells Open
Identification of mechanisms that program early effector T cells to either terminal effector T (T eff ) or memory T (T m ) cells has important implications for protective immunity against infections and cancers. Here, we show that the cyto…
View article: Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria
Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria Open
The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses antitumor T cell immunity. However, LA is a natural energy metabolite that can be oxidized in the…
View article: Linking microbial community composition to arsenic mobilization in the western Hetao Basin: Potential importance of ammonium as an electron donor
Linking microbial community composition to arsenic mobilization in the western Hetao Basin: Potential importance of ammonium as an electron donor Open
The western Hetao Basin was selected as the study area to address spatially-dependent correlations between microbial community composition and geochemical zonation, approximately along the groundwater flow path from a proximal fan (geochem…
View article: Aryl hydrocarbon receptor sulfenylation promotes glycogenolysis and rescues cancer chemoresistance
Aryl hydrocarbon receptor sulfenylation promotes glycogenolysis and rescues cancer chemoresistance Open
Elevation of reactive oxygen species (ROS) levels is a general consequence of tumor cells' response to treatment and may cause tumor cell death. Mechanisms by which tumor cells clear fatal ROS, thereby rescuing redox balance and entering a…
Challenges and Opportunities for Extracellular Vesicles in Clinical Oncology Therapy Open
Extracellular vesicles (EVs) are membrane-bound vesicles that can be released by all cell types. They may have different biogenesis, physical features, and cargo. EVs are important biomarkers for the diagnosis and prediction of many diseas…
View article: Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1
Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1 Open
Macrophages in tumors (tumor-associated macrophages, TAMs), a major population within most tumors, play key homeostatic functions by stimulating angiogenesis, enhancing tumor cell growth, and suppressing antitumor immunity. Resetting TAMs …
View article: TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells
TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells Open
Glycolysis facilitates the rapid recall response of CD8+ memory T (Tm) cells. However, it remains unclear whether Tm cells uptake exogenous glucose or mobilize endogenous sugar to fuel glycolysis. Here, we show that intracellular glycogen …
Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway Open
Pancreatic ductal adenocarcinoma (PDAC) originates from normal pancreatic ducts where digestive juice is regularly produced. It remains unclear how PDAC can escape autodigestion by digestive enzymes. Here we show that human PDAC tumour cel…
The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release Open
Enveloped virus particles are released from the membranes of host cells, and viral membrane proteins (M) are critical for this process. A better understanding of the molecular mechanisms of SARS-CoV-2 assembly and budding is critical for t…
Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program Open
Hypoxia is known to be commonly present in breast tumor microenvironments. Stem-like cells that repopulate breast tumors, termed tumor-repopulating cells (TRC), thrive under hypoxic conditions, but the underlying mechanism remains unclear.…
Characterization and Functional Analysis of Tumor‐Derived Microparticles Open
Microparticles (MPs) are heterogeneous populations of cell‐derived vesicles that play an important role in intercellular communications. The release of MPs by tumor cells is a very common event in tumor microenvironments (TMEs). Tumor cell…