Tim Liebner
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View article: Acetylation of histones and non-histone proteins is not a mere consequence of ongoing transcription
Acetylation of histones and non-histone proteins is not a mere consequence of ongoing transcription Open
In all eukaryotes, acetylation of histone lysine residues correlates with transcription activation. Whether histone acetylation is a cause or consequence of transcription is debated. One model suggests that transcription promotes the recru…
View article: A unique H2B acetylation signature marks active enhancers and predicts their target genes
A unique H2B acetylation signature marks active enhancers and predicts their target genes Open
Chromatin features are widely used for genome-scale mapping of enhancers. However, discriminating active enhancers from other cis-regulatory elements, predicting enhancer strength, and identifying their target genes remains challenging. He…
View article: HDAC6 modulates myofibril stiffness and diastolic function of the heart
HDAC6 modulates myofibril stiffness and diastolic function of the heart Open
Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augme…
View article: Histone deacetylase inhibitors butyrate and bufexamac inhibit<i>de novo</i>HIV-1 infection in CD4 T-cells
Histone deacetylase inhibitors butyrate and bufexamac inhibit<i>de novo</i>HIV-1 infection in CD4 T-cells Open
While current combined antiretroviral therapy (cART) allows control of HIV replication in patients and effectively suppresses plasma viral loads, it is unable to target latent reservoirs, which are responsible for virus rebound after disco…