Tzu‐Chieh Lin
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View article: Contribution of <i>Xeroderma Pigmentosum</i> Complementation Group C Genotypes to Colorectal Cancer in Taiwanese
Contribution of <i>Xeroderma Pigmentosum</i> Complementation Group C Genotypes to Colorectal Cancer in Taiwanese Open
Although the investigated XPC polymorphisms were not associated with CRC susceptibility, the rs2228000 and rs2228001 variant genotypes may serve as novel prognostic biomarkers. Further large-scale studies across diverse populations are rec…
View article: Comparative cardiovascular risk of sulfonylureas with low‐ and high‐affinities for cardiac mitochondrial adenosine triphosphate‐sensitive potassium channels versus dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes: A cohort study
Comparative cardiovascular risk of sulfonylureas with low‐ and high‐affinities for cardiac mitochondrial adenosine triphosphate‐sensitive potassium channels versus dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes: A cohort study Open
Aims To individually evaluate the cardiovascular safety of low‐ and high‐affinity cardiac mitochondrial ATP‐sensitive potassium (mitoK ATP ) channel sulfonylureas by comparing each to dipeptidyl peptidase‐4 inhibitors (DPP‐4i), a generally…
View article: Dipeptidyl Peptidase‐4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus and End‐Stage Renal Disease Requiring Dialysis
Dipeptidyl Peptidase‐4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus and End‐Stage Renal Disease Requiring Dialysis Open
Introduction Evidence on the safety of antidiabetic agents in end‐stage renal disease (ESRD) patients requiring dialysis, a group often excluded from randomized controlled trials, is scant. Dipeptidyl peptidase‐4 inhibitors (DPP‐4i), widel…
View article: The association of vascular access flow with sacubitril/valsartan and left ventricular ejection fraction in hemodialysis patients with heart failure with reduced ejection fraction
The association of vascular access flow with sacubitril/valsartan and left ventricular ejection fraction in hemodialysis patients with heart failure with reduced ejection fraction Open
Background Sacubitril/valsartan improves heart function in maintenance hemodialysis (HD) patients with heart failure with a reduced ejection fraction of <40% (HFrEF). However, the effect of sacubitril/valsartan on vascular access flow (…
View article: Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice
Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice Open
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease with limited treatment options and associated side effects or resistance. This study aims to investigate the therapeutic potential of the natural compound cucurbitacin B …
View article: The Potential for High-Priority Care Based on Pain Through Facial Expression Detection with Patients Experiencing Chest Pain
The Potential for High-Priority Care Based on Pain Through Facial Expression Detection with Patients Experiencing Chest Pain Open
Background and Objective: Cardiovascular disease (CVD), one of the chronic non-communicable diseases (NCDs), is defined as a cardiac and vascular disorder that includes coronary heart disease, heart failure, peripheral arterial disease, ce…
View article: A Vehicle Passive Entry Passive Start System with the Intelligent Internet of Things
A Vehicle Passive Entry Passive Start System with the Intelligent Internet of Things Open
With the development of sensor and communication technologies, the Internet of Things (IoT) subsystem is gradually becoming a crucial part in vehicles. It can effectively enhance functionalities of vehicles. However, new attack types are a…
View article: Impact of Vitamin D Receptor Genotypes on Taiwan Hallux Valgus
Impact of Vitamin D Receptor Genotypes on Taiwan Hallux Valgus Open
VDR rs731236, rs1544410, rs2228570, and rs7975232 may not serve as indicators for a higher risk of HV.
View article: Prediction of Prognosis in Patients with Trauma by Using Machine Learning
Prediction of Prognosis in Patients with Trauma by Using Machine Learning Open
Background and Objectives: We developed a machine learning algorithm to analyze trauma-related data and predict the mortality and chronic care needs of patients with trauma. Materials and Methods: We recruited admitted patients with trauma…
View article: Autologous Fat Plus Platelet-Rich Plasma versus Autologous Fat Alone on Sulcus Vocalis
Autologous Fat Plus Platelet-Rich Plasma versus Autologous Fat Alone on Sulcus Vocalis Open
Sulcus vocalis is a frequent cause of glottic insufficiency that leads to incomplete vocal fold closure during phonation. Type II sulcus vocalis is defined as a partial defect of the lamina propria (LP). Treatment with fillers, such as fat…
View article: Association of<i>EZH2</i>Genotypes With Oral Cancer Risk
Association of<i>EZH2</i>Genotypes With Oral Cancer Risk Open
EZH2 genotypes cannot predict oral cancer risk in Taiwan.
View article: Predicting outcomes after trauma: Prognostic model development based on admission features through machine learning.
Predicting outcomes after trauma: Prognostic model development based on admission features through machine learning. Open
In an overcrowded emergency department (ED), trauma surgeons and emergency physicians need an accurate prognostic predictor for critical decision-making involving patients with severe trauma. We aimed to develope a machine learning-based e…
View article: Predicting outcomes after trauma
Predicting outcomes after trauma Open
In an overcrowded emergency department (ED), trauma surgeons and emergency physicians need an accurate prognostic predictor for critical decision-making involving patients with severe trauma. We aimed to develope a machine learning-based e…
View article: Cardiac Arrest Survival Postresuscitation In-Hospital (CASPRI) Score Predicts Neurological Favorable Survival in Emergency Department Cardiac Arrest
Cardiac Arrest Survival Postresuscitation In-Hospital (CASPRI) Score Predicts Neurological Favorable Survival in Emergency Department Cardiac Arrest Open
Background: This study was conducted to identify the predictive factors for survival and favorable neurological outcome in patients with emergency department cardiac arrest (EDCA). Methods: ED patients who suffered from in-hospital cardiac…
View article: Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of Listeria monocytogenes: A 9-Year Hospital-Based Study
Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of Listeria monocytogenes: A 9-Year Hospital-Based Study Open
Background: Listeria monocytogenes (LM) is a facultative anaerobe, Gram-positive bacillus which is widely distributed in nature, and can be separated from soil, water, and rotten vegetables. Immunocompetent people are less likely to suffer…
View article: Antifibrotic Effect of Bletilla striata Polysaccharide-Resveratrol-Impregnated Dual-Layer Carboxymethyl Cellulose-Based Sponge for The Prevention of Epidural Fibrosis after Laminectomy
Antifibrotic Effect of Bletilla striata Polysaccharide-Resveratrol-Impregnated Dual-Layer Carboxymethyl Cellulose-Based Sponge for The Prevention of Epidural Fibrosis after Laminectomy Open
The application of antifibrotic materials can alleviate epidural fibrosis by restricting excessive fibroblast proliferation and mitigating scar tissue formation. Here, a biodegradable carboxymethyl cellulose (CMC)-Bletilla striata polysacc…
View article: Comprehensive Geriatric Assessment and Clinical Outcomes in the Older People at the Emergency Department
Comprehensive Geriatric Assessment and Clinical Outcomes in the Older People at the Emergency Department Open
Visits by older people to the Emergency Department (ED) have increased in recent decades with higher revisiting and admission rates after discharge, particularly for those with frailties. This study used a before–after design aimed at eval…
View article: Effect of ambient air pollution on the incidence of colorectal cancer among a diabetic population: a nationwide nested case–control study in Taiwan
Effect of ambient air pollution on the incidence of colorectal cancer among a diabetic population: a nationwide nested case–control study in Taiwan Open
Objectives An increasing number of studies had shown that air pollution exposure may aggravate blood glucose control in patients with diabetes, an independent risk factor for colorectal cancer (CRC) proposed by some researchers. This study…
View article: 2019 novel coronavirus disease (COVID-19) in Taiwan: Reports of two cases from Wuhan, China
2019 novel coronavirus disease (COVID-19) in Taiwan: Reports of two cases from Wuhan, China Open
We reported two cases with community-acquired pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who returned from Wuhan, China in January, 2020. The reported cases highlight non-specific clinical presentation…
View article: Psoas abscess associated with aortic endograft infection caused by bacteremia of Listeria monocytogenes
Psoas abscess associated with aortic endograft infection caused by bacteremia of Listeria monocytogenes Open
Rationale: Endograft infection following endovascular stent for aortic aneurysm is rare (0.6%–3%), but it results in high mortality rate of 25% to 88%. Patient concerns: A 66-year-old hypertensive man underwent an endovascular stent graft …
View article: Statins improve the long-term prognosis in patients who have survived sepsis
Statins improve the long-term prognosis in patients who have survived sepsis Open
Most patients diagnosed with sepsis died during their first episode, with the long-term survival rate upon post-sepsis discharge being low. Major adverse cardiovascular events and recurrent infections were regarded as the major causes of d…
View article: Primary aortoduodenal fistula associated with abdominal aortic aneurysm with presentation of gastrointestinal bleeding: a case report
Primary aortoduodenal fistula associated with abdominal aortic aneurysm with presentation of gastrointestinal bleeding: a case report Open
A timely and accurate diagnosis of primary ADF may be challenging due to insidious episodes of GI bleeding, which are frequently under-diagnosed until the occurrence of massive hemorrhage. Clinical physicians should keep a high index of aw…
View article: Population study evaluating fracture risk among patients with chronic osteomyelitis
Population study evaluating fracture risk among patients with chronic osteomyelitis Open
Findings in this 15-year follow-up observation support our hypothesis that patients with COM are at an elevated risk of subsequent fracture. COM patients and the elderly deserve adequate consultation and awareness for fracture prevention.
View article: Prostatic abscess of Klebsiella pneumonia complicating septic pulmonary emboli and meningitis: A case report and brief review
Prostatic abscess of Klebsiella pneumonia complicating septic pulmonary emboli and meningitis: A case report and brief review Open
Prostatic abscess is a rare entity with an incidence of 0.5%-2.5% in all prostate diseases and usually occurs in the 5th and 6th decades of life with immunocompromised status. Prostatic abscess might be a process of evolution from acute pr…
View article: Trends of CT utilisation in an emergency department in Taiwan: a 5-year retrospective study
Trends of CT utilisation in an emergency department in Taiwan: a 5-year retrospective study Open
Objectives To investigate the association between the trends of CT utilisation in an emergency department (ED) and changes in clinical imaging practice and patients' disposition. Setting A hospital-based retrospective observational study o…
View article: Cold Limb in Blunt Knee Injury
Cold Limb in Blunt Knee Injury Open
Case Presentation: A 31-year-old healthy Taiwanese man presented a cold extremity below right knee caused by contusion due to falling down in a traffic accident. Physical examination showed tenderness of right swollen knee with absent puls…
View article: The incidence of symptomatic venous thromboembolism following hip fractures with or without surgery in Taiwan
The incidence of symptomatic venous thromboembolism following hip fractures with or without surgery in Taiwan Open
Information on the incidence of venous thromboembolism (VTE) following hip fractures in Asia is rare. This study will investigate the epidemiology of symptomatic VTE in Taiwanese patients experiencing hip fractures. We used Taiwan's Nation…
View article: Dementia Increases Severe Sepsis and Mortality in Hospitalized Patients With Chronic Obstructive Pulmonary Disease
Dementia Increases Severe Sepsis and Mortality in Hospitalized Patients With Chronic Obstructive Pulmonary Disease Open
Dementia increases the risk of morbidity and mortality in hospitalized patients. However, information on the potential effects of dementia on the risks of acute organ dysfunction, severe sepsis and in-hospital mortality, specifically among…