Tim M. Bruns
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View article: Selective motor stimulation of the pudendal nerve using multi-contact cuff electrodes: a pre-clinical study in feline and ovine models
Selective motor stimulation of the pudendal nerve using multi-contact cuff electrodes: a pre-clinical study in feline and ovine models Open
Introduction Pudendal nerve stimulation is a promising therapy for urinary incontinence, however stimulation can evoke off-target activity. We aimed to determine whether multi-contact cuff electrodes can selectively recruit motor fibers of…
View article: Physiological activity within peripheral nerves influences neural output in response to electrical stimulation: an <i>in vivo</i> study
Physiological activity within peripheral nerves influences neural output in response to electrical stimulation: an <i>in vivo</i> study Open
Objective. Neuromodulation therapies are often applied to peripheral nerves. These nerves can have physiological activity that interacts with the activity evoked by electrical stimulation, potentially influencing targeted neural output and…
View article: Factors Affecting Anal Sphincter Recruitment During Intraoperative Pudendal Nerve Stimulation: An Observational Study
Factors Affecting Anal Sphincter Recruitment During Intraoperative Pudendal Nerve Stimulation: An Observational Study Open
Introduction and Hypothesis The relationship between pudendal neuromodulation and patient factors is not well understood. This observational study was aimed at identifying and quantifying physiological, demographic, and stimulation factors…
View article: Perineal and Rectal Nerve Recruitment Order Varies During Pudendal Neurostimulator Implant Surgery
Perineal and Rectal Nerve Recruitment Order Varies During Pudendal Neurostimulator Implant Surgery Open
Introduction Pudendal nerve stimulation (PNS) is an off‐label therapy for patients experiencing pelvic pain and voiding dysfunction. The pudendal nerve has two efferent branches to the rectum and perineum. Only the rectal branch is monitor…
View article: Non-continuous neuromodulation in awake, unrestrained felines increases bladder capacity
Non-continuous neuromodulation in awake, unrestrained felines increases bladder capacity Open
Objective Neuromodulation is a standard therapy for bladder symptoms such as overactive bladder. Previous studies have demonstrated that non-continuous stimulation can increase bladder capacity, and that bladder pressure can be estimated f…
View article: Physiological activity within peripheral nerves influences neural output in response to electrical stimulation: an<i>in vivo</i>study
Physiological activity within peripheral nerves influences neural output in response to electrical stimulation: an<i>in vivo</i>study Open
Neuromodulation therapies are often applied to peripheral nerves. These nerves can have physiological activity that interacts with the activity evoked by electrical stimulation, potentially influencing targeted neural output and clinical o…
View article: CT and MR Imaging v1
CT and MR Imaging v1 Open
This protocol summarizes the MRI scans used to visualize and segment the pudendal nerve i and the CT scan used to identify the location of an implanted pudendal stimulation lead. Together these scans can be used to determine the position o…
View article: Perineal and rectal nerve recruitment order varies during pudendal neurostimulator implant surgery
Perineal and rectal nerve recruitment order varies during pudendal neurostimulator implant surgery Open
Introduction Pudendal nerve stimulation (PNS) is an off-label therapy for patients experiencing pelvic pain and voiding dysfunction. The pudendal nerve has two efferent branches to the rectum and perineum. Only the rectal branch is monitor…
View article: Factors affecting anal sphincter recruitment during intraoperative pudendal nerve stimulation: an observational study
Factors affecting anal sphincter recruitment during intraoperative pudendal nerve stimulation: an observational study Open
Introduction and Hypothesis The relationship between pudendal neuromodulation and patient factors is not well understood. This observational study aimed to identify and quantify physiological, demographic, and stimulation factors that sign…
View article: Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: a computational modeling study
Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: a computational modeling study Open
We built a computational model of sensory neurons in the dorsal root ganglia to investigate factors that influence the extracellular waveforms recorded by microelectrodes. Our model demonstrates how the unique structure of these neurons ca…
View article: Pudendal Nerve Mapping in Humans v1
Pudendal Nerve Mapping in Humans v1 Open
The goal of this study is to map the pudendal nerve with imaging and electrophysiology by gathering additional data from patients receiving an implanted neurostimulator as part of their normal clinical care, and to examine the response of …
View article: Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: A computational modeling study
Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: A computational modeling study Open
Microelectrodes serve as a fundamental tool in electrophysiology research throughout the nervous system, providing a means of exploring neural function with a high resolution of neural firing information. We constructed a hybrid computatio…
View article: (058) Acute Dorsal Genital Neuromodulation can Improve Subjective Arousal: A Pilot Study in Women With and Without Spinal Cord Injury
(058) Acute Dorsal Genital Neuromodulation can Improve Subjective Arousal: A Pilot Study in Women With and Without Spinal Cord Injury Open
Introduction Female sexual dysfunction (FSD) is a potentially life altering condition that impacts an estimated 40% of women. Unfortunately, the few treatment options available have limited success due to adverse events and an inability to…
View article: Acute dorsal genital nerve stimulation increases subjective arousal in women with and without spinal cord injury: a preliminary investigation
Acute dorsal genital nerve stimulation increases subjective arousal in women with and without spinal cord injury: a preliminary investigation Open
Introduction Female sexual dysfunction (FSD) impacts an estimated 40% of women. Unfortunately, female sexual function is understudied, leading to limited treatment options for FSD. Neuromodulation has demonstrated some success in improving…
View article: Pudendal, but not tibial, nerve stimulation modulates vulvar blood perfusion in anesthetized rodents
Pudendal, but not tibial, nerve stimulation modulates vulvar blood perfusion in anesthetized rodents Open
View article: Immediate and Long-Term Effects of Tibial Nerve Stimulation on the Sexual Behavior of Female Rats
Immediate and Long-Term Effects of Tibial Nerve Stimulation on the Sexual Behavior of Female Rats Open
Objectives There are limited treatment options for female sexual dysfunction (FSD). Percutaneous tibial nerve stimulation (PTNS) has shown improvements in FSD symptoms in neuromodulation clinical studies, but the direct effects on sexual f…
View article: Ultraflexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon‐Dimension, Cuff‐Less Microneedle Electrode Array
Ultraflexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon‐Dimension, Cuff‐Less Microneedle Electrode Array Open
Peripheral nerve mapping tools with higher spatial resolution are needed to advance systems neuroscience, and potentially provide a closed‐loop biomarker in neuromodulation applications. Two critical challenges of microscale neural interfa…
View article: Closed-loop sacral neuromodulation for bladder function using dorsal root ganglia sensory feedback in an anesthetized feline model
Closed-loop sacral neuromodulation for bladder function using dorsal root ganglia sensory feedback in an anesthetized feline model Open
View article: Pudendal, but not tibial, nerve stimulation modulates vulvar blood perfusion in anesthetized rodents
Pudendal, but not tibial, nerve stimulation modulates vulvar blood perfusion in anesthetized rodents Open
Introduction and Hypothesis Preclinical studies have shown that neuromodulation can increase vaginal blood perfusion, but the effect on vulvar blood perfusion is unknown. We hypothesized that pudendal and tibial nerve stimulation could evo…
View article: Ultra-flexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-dimension, Cuff-less Microneedle Electrode Array
Ultra-flexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-dimension, Cuff-less Microneedle Electrode Array Open
Peripheral nerve mapping tools with higher spatial resolution are needed to advance systems neuroscience, and potentially provide a closed-loop biomarker in neuromodulation applications. Two critical challenges of microscale neural interfa…
View article: Tibial nerve stimulation increases vaginal blood perfusion and bone mineral density and yield load in ovariectomized rat menopause model
Tibial nerve stimulation increases vaginal blood perfusion and bone mineral density and yield load in ovariectomized rat menopause model Open
Introduction and Hypothesis Human menopause transition and post-menopausal syndrome, driven by reduced ovarian activity and estrogen levels, are associated with an increased risk for symptoms including but not limited to sexual dysfunction…
View article: Sharpened and mechanically durable carbon fiber electrode arrays for neural interfacing
Sharpened and mechanically durable carbon fiber electrode arrays for neural interfacing Open
Bioelectric medicine treatments target disorders of the nervous system unresponsive to pharmacological methods. While current stimulation paradigms effectively treat many disorders, the underlying mechanisms are relatively unknown, and cur…
View article: Sharpened and Mechanically Durable Carbon Fiber Electrode Arrays for Neural Recording
Sharpened and Mechanically Durable Carbon Fiber Electrode Arrays for Neural Recording Open
Bioelectric medicine treatments target disorders of the nervous system unresponsive to pharmacological methods. While current stimulation paradigms effectively treat many disorders, the underlying mechanisms are relatively unknown, and cur…
View article: Bladder pressure encoding by sacral dorsal root ganglion fibres: implications for decoding
Bladder pressure encoding by sacral dorsal root ganglion fibres: implications for decoding Open
Objective. We aim at characterising the encoding of bladder pressure (intravesical pressure) by a population of sensory fibres. This research is motivated by the possibility to restore bladder function in elderly patients or after spinal c…
View article: Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array
Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array Open
Autonomic nerves convey essential neural signals that regulate vital body functions. Recording clearly distinctive physiological neural signals from autonomic nerves will help develop new treatments for restoring regulatory functions. Howe…
View article: High-density Neural Recordings from Feline Sacral Dorsal Root Ganglia with Thin-film Array
High-density Neural Recordings from Feline Sacral Dorsal Root Ganglia with Thin-film Array Open
Objective: Dorsal root ganglia (DRG) are promising sites for recording sensory activity. Current technologies for DRG recording are stiff and typically do not have sufficient site density for high-fidelity neural data techniques. Approach:…
View article: Anesthetic agents affect urodynamic parameters and anesthetic depth at doses necessary to facilitate preclinical testing in felines
Anesthetic agents affect urodynamic parameters and anesthetic depth at doses necessary to facilitate preclinical testing in felines Open
View article: The Effect of Clinically Controllable Factors on Neural Activation During Dorsal Root Ganglion Stimulation
The Effect of Clinically Controllable Factors on Neural Activation During Dorsal Root Ganglion Stimulation Open
View article: Novel diamond shuttle to deliver flexible neural probe with reduced tissue compression
Novel diamond shuttle to deliver flexible neural probe with reduced tissue compression Open
View article: Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array
Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array Open
Autonomic nerves convey essential neural signals that regulate vital body functions. Recording clearly distinctive physiological neural signals from autonomic nerves will help develop new treatments for restoring regulatory functions. Howe…